Iucundus nominis error (Ov. Ars 3, 729). Procri rustica puella nell’Ars amatoria

Alla fine del terzo libro dell’Ars, Ovidio esorta le cultae lettrici a non dare spazio al sentimento della gelosia, estraneo all’adulterino mondo dell’elegia erotica, e introduce il mito dell’amore infelice di Cefalo e Procri (3, 683-746), exemplum ‘serio’ (non leve) delle nefaste conseguenze di un atteggiamento non moderato in amore. Il presente contributo focalizza l’attenzione sulla figura di Procri come anti-exemplum, modello oppositivo della elegiaca femina culta, e legge la ‘credulità’ della fanciulla, vittima dell’inganno prodotto dal nome della presunta rivale (aura), alla luce della rusticitas che delinea le similari figure di puellae abbandonate delle Heroides. Nella cornice didascalica ovidiana il mito funziona come modello culturale contrario all’estetica del decorum. La ricerca della moderazione e l’invito al rispetto del modus costituiscono il fulcro del messaggio dell’Ars. Connotato come ‘dramma dell’inganno dell’eros’, il mito di Procri si presta a divenire exemplum negativo di insania amorosa, modello perduto di simplicitas che viola i paradigmi dell’amore elegiaco e mal s’addice all’aetas ovidiana del cultus e della raffinatezza

Iucundus nominis error (Ov. Ars 3, 729): Procri rustica puella nell’Ars amatoria

Alla fine del terzo libro dell’Ars, Ovidio esorta le cultae lettrici a non dare spazio al sentimento della gelosia, estraneo all’adulterino mondo dell’elegia erotica, e introduce il mito dell’amore infelice di Cefalo e Procri (3, 683-746), exemplum ‘serio’ (non leve) delle nefaste conseguenze di un atteggiamento non moderato in amore. Il presente contributo focalizza l’attenzione sulla figura di Procri come anti-exemplum, modello oppositivo della elegiaca femina culta, e legge la ‘credulità’ della fanciulla, vittima dell’inganno prodotto dal nome della presunta rivale (aura), alla luce della rusticitas che delinea le similari figure di puellae abbandonate delle Heroides. Nella cornice didascalica ovidiana il mito funziona come modello culturale contrario all’estetica del decorum. La ricerca della moderazione e l’invito al rispetto del modus costituiscono il fulcro del messaggio dell’Ars. Connotato come ‘dramma dell’inganno dell’eros’, il mito di Procri si presta a divenire exemplum negativo di insania amorosa, modello perduto di simplicitas che viola i paradigmi dell’amore elegiaco e mal s’addice all’aetas ovidiana del cultus e della raffinatezza

Przewlekła niewydolność nerek u dzieci – ocena stanu zdrowia jamy ustnej

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cva with wrong way risk in the presence of early exercise

Hull–White approach of CVA with embedded WWR (Hull and White, Financ. Anal. J. 68:58-69, 2012, [11]) can be easily applied also to portfolios of derivatives with early termination features. The tree-based approach described in Baviera et al. (Int. J. Financ. Eng. 2015, [1]) allows to deal with American or Bermudan options in a straightforward way. Extensive numerical results highlight the nontrivial impact of early exercise on CVA

Aberrant Mitochondrial Homeostasis in the Skeletal Muscle of Sedentary Older Adults

The role of mitochondrial dysfunction and oxidative stress has been extensively characterized in the aetiology of sarcopenia (aging-associated loss of muscle mass) and muscle wasting as a result of muscle disuse. What remains less clear is whether the decline in skeletal muscle mitochondrial oxidative capacity is purely a function of the aging process or if the sedentary lifestyle of older adult subjects has confounded previous reports. The objective of the present study was to investigate if a recreationally active lifestyle in older adults can conserve skeletal muscle strength and functionality, chronic systemic inflammation, mitochondrial biogenesis and oxidative capacity, and cellular antioxidant capacity. To that end, muscle biopsies were taken from the vastus lateralis of young and age-matched recreationally active older and sedentary older men and women (N = 10/group; ♀  =  ♂). We show that a physically active lifestyle is associated with the partial compensatory preservation of mitochondrial biogenesis, and cellular oxidative and antioxidant capacity in skeletal muscle of older adults. Conversely a sedentary lifestyle, associated with osteoarthritis-mediated physical inactivity, is associated with reduced mitochondrial function, dysregulation of cellular redox status and chronic systemic inflammation that renders the skeletal muscle intracellular environment prone to reactive oxygen species-mediated toxicity. We propose that an active lifestyle is an important determinant of quality of life and molecular progression of aging in skeletal muscle of the elderly, and is a viable therapy for attenuating and/or reversing skeletal muscle strength declines and mitochondrial abnormalities associated with aging

Resistance Exercise Reverses Aging in Human Skeletal Muscle

Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. Skeletal muscle biopsies from healthy older (N = 25) and younger (N = 26) adult men and women were compared using gene expression profiling, and a subset of these were related to measurements of muscle strength. 14 of the older adults had muscle samples taken before and after a six-month resistance exercise-training program. Before exercise training, older adults were 59% weaker than younger, but after six months of training in older adults, strength improved significantly (P<0.001) such that they were only 38% lower than young adults. As a consequence of age, we found 596 genes differentially expressed using a false discovery rate cut-off of 5%. Prior to the exercise training, the transcriptome profile showed a dramatic enrichment of genes associated with mitochondrial function with age. However, following exercise training the transcriptional signature of aging was markedly reversed back to that of younger levels for most genes that were affected by both age and exercise. We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training

Association of Mitochondrial DNA Variations with Lung Cancer Risk in a Han Chinese Population from Southwestern China

Mitochondrial DNA (mtDNA) is particularly susceptible to oxidative damage and mutation due to the high rate of reactive oxygen species (ROS) production and limited DNA-repair capacity in mitochondrial. Previous studies demonstrated that the increased mtDNA copy number for compensation for damage, which was associated with cigarette smoking, has been found to be associated with lung cancer risk among heavy smokers. Given that the common and “non-pathological” mtDNA variations determine differences in oxidative phosphorylation performance and ROS production, an important determinant of lung cancer risk, we hypothesize that the mtDNA variations may play roles in lung cancer risk. To test this hypothesis, we conducted a case-control study to compare the frequencies of mtDNA haplogroups and an 822 bp mtDNA deletion between 422 lung cancer patients and 504 controls. Multivariate logistic regression analysis revealed that haplogroups D and F were related to individual lung cancer resistance (OR = 0.465, 95%CI = 0.329–0.656, p<0.001; and OR = 0.622, 95%CI = 0.425–0.909, p = 0.014, respectively), while haplogroups G and M7 might be risk factors for lung cancer (OR = 3.924, 95%CI = 1.757–6.689, p<0.001; and OR = 2.037, 95%CI = 1.253–3.312, p = 0.004, respectively). Additionally, multivariate logistic regression analysis revealed that cigarette smoking was a risk factor for the 822 bp mtDNA deletion. Furthermore, the increased frequencies of the mtDNA deletion in male cigarette smoking subjects of combined cases and controls with haplogroup D indicated that the haplogroup D might be susceptible to DNA damage from external ROS caused by heavy cigarette smoking

2 nd Brazilian Consensus on Chagas Disease, 2015

Abstract Chagas disease is a neglected chronic condition with a high burden of morbidity and mortality. It has considerable psychological, social, and economic impacts. The disease represents a significant public health issue in Brazil, with different regional patterns. This document presents the evidence that resulted in the Brazilian Consensus on Chagas Disease. The objective was to review and standardize strategies for diagnosis, treatment, prevention, and control of Chagas disease in the country, based on the available scientific evidence. The consensus is based on the articulation and strategic contribution of renowned Brazilian experts with knowledge and experience on various aspects of the disease. It is the result of a close collaboration between the Brazilian Society of Tropical Medicine and the Ministry of Health. It is hoped that this document will strengthen the development of integrated actions against Chagas disease in the country, focusing on epidemiology, management, comprehensive care (including families and communities), communication, information, education, and research