5,128 research outputs found

    Advice from creative consumers: a study of online hotel reviews

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    This study explores what creative consumers are compelled to say about hotels through online reviews. Online reviews are highly influential, with consumers preferring the advice of other consumers over industry experts or information provided by the marketer. Over 7,000 online hotel reviews posted on TripAdvisor were examined, using Leximancer, a content analysis tool. This study provides insights on the factors contributing to guest satisfaction and dissatisfaction in luxury hotels and moderate hotels. It also demonstrates the importance of the information provided by creative consumers, both in terms of market research and as part of an overall marketing communications initiative

    The effect of normal and abnormal ageing on prospective memory showed increased cognitive conflict: a functional MRI study

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    INTRODUCTION: Prospective memory (PM) is memory for planned intention, which needs to be executed appropriately in the future. PM task is usually embedded in ongoing activities. The neural correlates of PM have not been elucidated. To date, no functional imaging study has been conducted to examine the relevant functional change of PM during the processes of ageing and ...published_or_final_versio

    Are health websites ready for the mobile world? A study of readability among traditional and mobile websites

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    More people are expected to access online information from mobile devices than from personal computers by 2015. This study asks whether the websites of health organizations have taken into consideration the greater difficulty of reading text on the small screens of mobile phones. Specifically, this study examines readability scores of traditional websites and mobile websites among 55 American health organizations. While 22% of the organizations studied had mobile websites, only one-third of the mobile websites had better readability than their traditional website counterparts. The Grade Level Score for these mobile websites averaged 6.5 compared to 8.5 for their traditional websites but none had superior readability of 5th grade level or lower. Conversely, another one-third of the mobile websites had worse readability than their traditional website counterparts. These findings suggest most health organizations have yet to leverage the accessibility of online information through mobile phones

    Luxury branding in emerging markets

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    In March 2012, Gap entered the South African market, but with a different pricing strategy to the one followed in the USA. While the brand is known as an affordable clothing brand in the USA, its goods were priced substantially higher in South Africa than in the USA. The same Gap T-shirt sold for 16intheUSAwasbeingsoldat16 in the USA was being sold at 40 in South Africa. The positioning of the Gap brand as a luxury brand in the South African market suggests that what constitutes a luxury brand is not the same across global markets. This paper explores whether this mode of market entry is a sustainable business model or if the mode of entry is only viable for short-term success. In pursuing this line of thinking, the concept of the opportunistic luxury brand is presented. An opportunistic luxury brand is defined as a brand that is not normally known as a luxury brand in other markets (i.e. other countries) and is adopting a luxury brand positioning in a particular market. This paper develops and offers a research agenda for luxury brands in emerging markets

    Relevance of short-range connectivity to brain compensation and cognitive efficiency in healthy and pathological ageing: a combined functional magnetic resonance imaging and tractography study on prospective memory

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    INTRODUCTION: Cognition and its efficiency are related to the activities of specific brain regions and their interactions. The brain function and structure are vulnerable to both healthy and pathological ageing, and these processes may underlie the impaired cognitive functions in daily life …published_or_final_versio

    The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood

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    Dysregulation of splicing factor expression is emerging as a driver of human ageing; levels of transcripts encoding splicing regulators have previously been implicated in ageing and cellular senescence both in vitro and in vivo. We measured the expression levels of an a priori panel of 20 age- or senescence-associated splicing factors by qRT-PCR in peripheral blood samples from the InCHIANTI Study of Aging, and assessed longitudinal relationships with human ageing phenotypes (cognitive decline and physical ability) using multivariate linear regression. AKAP17A, HNRNPA0 and HNRNPM transcript levels were all predictively associated with severe decline in MMSE score (p = 0.007, 0.001 and 0.008 respectively). Further analyses also found expression of these genes was associated with a performance decline in two other cognitive measures; the Trail Making Test and the Purdue Pegboard Test. AKAP17A was nominally associated with a decline in mean hand-grip strength (p = 0.023), and further analyses found nominal associations with two other physical ability measures; the Epidemiologic Studies of the Elderly-Short Physical Performance Battery and calculated speed (m/s) during a timed 400 m fast walking test. These data add weight to the hypothesis that splicing dyregulation may contribute to the development of some ageing phenotypes in the human population.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.This work was funded by the Velux Stiftung Foundation (Grant Number 822) and supported in part by the Intramural Research Program of the NIH, National institute on Aging.published version, accepted version (12 month embargo

    Direct observation of delithiation as the origin of analog memristance in LixNbO2

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    The discovery of analog LixNbO2 memristors revealed a promising new memristive mechanism wherein the diffusion of Li+ rather than O2- ions enables precise control of the resistive states. However, directly correlating lithium concentration with changes to the electronic structure in active layers remains a challenge and is required to truly understand the underlying physics. Chemically delithiated single crystals of LiNbO2 present a model system for correlating lithium variation with spectroscopic signatures from operando soft x-ray spectroscopy studies of device active layers. Using electronic structure modeling of the x-ray spectroscopy of LixNbO2 single crystals, we demonstrate that the intrinsic memristive behavior in LixNbO2 active layers results from field-induced degenerate p-type doping. We show that electrical operation of LixNbO2-based memristors is viable even at marginal Li deficiency and that the analog memristive switching occurs well before the system is fully metallic. This study serves as a benchmark for material synthesis and characterization of future LixNbO2-based memristor devices and suggests that valence change switching is a scalable alternative that circumvents the electroforming typically required for filamentary-based memristors

    Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels.

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    This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record Dietary restriction (DR) represents one of the most reproducible interventions to extend lifespan and improve health outcomes in a wide range of species, but substantial variability in DR response has been observed, both between and within species. The mechanisms underlying this variation in effect are still not well characterised. Splicing regulatory factors have been implicated in the pathways linked with DR-induced longevity in C. elegans and are associated with lifespan itself in mice and humans. We used qRT-PCR to measure the expression levels of a panel of 20 age- and lifespan-associated splicing regulatory factors in brain, heart and kidney derived from three recombinant inbred strains of mice with variable lifespan responses to short-term (2 months) or long-term (10 months) 40% DR to determine their relationship to DR-induced longevity. We identified 3 patterns of association; i) splicing factors associated with DR alone, ii) splicing factors associated with strain alone or iii) splicing factors associated with both DR and strain. Tissue specific variation was noted in response to short term or long-term DR, with the majority of effects noted in brain following long term DR in the positive responder strain TejJ89. Association in heart and kidney were less evident, and occurred following short term DR. Splicing factors associated with both DR and strain may be mechanistically involved in strain-specific differences in response to DR. We provide here evidence concordant with a role for some splicing factors in the lifespan modulatory effects of DR across different mouse strains and in different tissues

    Low energy intensity production of fuel-grade bio-butanol enabled by membrane-based extraction

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    Widespread use of biofuels is inhibited by the significant energy burden of recovering fuel products from aqueous fermentation systems. Here, we describe a membrane-based extraction (perstraction) system for the recovery of fuel-grade biobutanol from fermentation broths which can extract n-butanol with high purity (>99.5%) while using less than 25% of the energy of current technology options. This is achieved by combining a spray-coated thin-film composite membrane with 2-ethyl-1-hexanol as an extractant. The membrane successfully protects the micro-organisms from the extractant, which, although ideal in other respects, is a metabolic inhibitor. In contrast to water, the extractant does not form a heterogeneous azeotrope with n-butanol, and the overall energy consumption of for n-butanol production is 3.9 MJ kg−1, substantially less than other recovery processes (17.0–29.4 MJ kg−1). By (a) extracting n-butanol from the fermentation broth without a phase change, (b) breaking the heterogeneous azeotrope relationship (less energy consumption for distillation), and (c) utilizing a small volume ratio of extractant : fermentation broth (1 : 100, v/v), the need for high energy intensity processes such as pervaporation, gas stripping or liquid–liquid extraction is avoided. The application of this perstraction system to continuous production of a range of higher alcohols is explored and shown to be highly favourable
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