Hydrogen Peroxide Wound Irrigation in Orthopaedic Surgery.

As the burden of deep hardware infections continues to rise in orthopaedics, there is increasing interest in strategies for more effective debridement of colonized tissues and biofilm. Hydrogen peroxide has been used medically for almost a century, but its applications in orthopaedic surgery have yet to be fully determined. The basic science and clinical research on the antiseptic efficacy of hydrogen peroxide have demonstrated its efficacy against bacteria, and it has demonstrated potential synergy with other irrigation solutions such as chlorhexidine and povidone-iodine. While hydrogen peroxide is effective in infection reduction, there are concerns with wound healing, cytotoxicity, and embolic phenomena, and we recommend against hydrogen peroxide usage in the treatment of partial knee replacements, hemiarthroplasties, or native joints. Additionally, due to the potential for oxygen gas formation, hydrogen peroxide should not be used in cases of dural compromise, when pressurizing medullary canals, or when irrigating smaller closed spaces to avoid the possibility of air embolism. Finally, we present our protocol for irrigation and debridement and exchange of modular components in total joint arthroplasty, incorporating hydrogen peroxide in combination with povidone-iodine and chlorhexidine

Non-photorealistic volume rendering using stippling techniques

Journal ArticleSimulating hand-drawn illustration techniques can succinctly express information in a manner that is communicative and informative. We present a framework for an interactive direct volume illustration system that simulates traditional stipple drawing. By combining the principles of artistic and scientific illustration, we explore several feature enhancement techniques to create effective, interactive visualizations of scientific and medical datasets. We also introduce a rendering mechanism that generates appropriate point lists at all resolutions during an automatic preprocess, and modifies rendering styles through different combinations of these feature enhancements. The new system is an effective way to interactively preview large, complex volume datasets in a concise, meaningful, and illustrative manner. Volume stippling is effective for many applications and provides a quick and efficient method to investigate volume models

Illustrative interactive stipple rendering

Journal ArticleAbstract-Simulating hand-drawn illustration can succinctly express information in a manner that is communicative and informative. We present a framework for an interactive direct stipple rendering of volume and surface-based objects. By combining the principles of artistic and scientific illustration, we explore several feature enhancement techniques to create effective, interactive visualizations of scientific and medical data sets. We also introduce a rendering mechanism that generates appropriate point lists at all resolutions during an automatic preprocess and modifies rendering styles through different combinations of these feature enhancements. The new system is an effective way to interactively preview large, complex volume and surface data sets in a concise, meaningful, and illustrative manner. Stippling is effective for many applications and provides a quick and efficient method to investigate both volume and surface models

The spatial and velocity distributions of hypervelocity stars

Hypervelocity stars (HVSs) found in the Galactic halo are probably the dynamical products of interactions between (binary) stars and the massive black hole(s) (MBH) in the Galactic center (GC). It has been shown that the detected HVSs are spatially consistent with being located on two thin disks (Lu et al.), one of which has the same orientation as the clockwise-rotating stellar disk in the GC. Here we perform a large number of three-body experiments of the interactions between the MBH and binary stars bound to it, and find that the probability of ejecting HVSs is substantially enhanced by multiple encounters between the MBH and binary stars at distances substantially larger than the initial tidal breakup radii. Assuming that the HVS progenitors are originated from the two disks, the inclination distribution of the HVSs relative to the disk planes can be reproduced by either the mechanism of tidal breakup of binary stars or the mechanism of ejecting HVSs by a hypothetical binary black hole (BBH) in the GC. However, an isotropical origination of HVS progenitors is inconsistent with the observed inclination distribution. Assuming that the HVSs were ejected out by the tidal breakup mechanism, its velocity distribution can be reproduced if their progenitors diffuse onto low angular momentum orbits slowly and most of the progenitors were broken up at relatively large distances due to multiple encounters. Assuming that the HVSs were ejected out by a BBH within the allowed parameter space in the GC, our simulations produce relatively flatter velocity spectra compared to the observed ones; however, the BBH mechanism cannot be statistically ruled out, yet. Future surveys of HVSs and better statistics of their spatial and velocity distributions should enable to distinguish the ejection mechanisms of HVSs and shed new light on the dynamical environment of the MBH.(abridged)Comment: 19 pages, 16 figure

Connecting Surrogate Safety Measures to Crash Probablity via Causal Probabilistic Time Series Prediction

Surrogate safety measures can provide fast and pro-active safety analysis and give insights on the pre-crash process and crash failure mechanism by studying near misses. However, validating surrogate safety measures by connecting them to crashes is still an open question. This paper proposed a method to connect surrogate safety measures to crash probability using probabilistic time series prediction. The method used sequences of speed, acceleration and time-to-collision to estimate the probability density functions of those variables with transformer masked autoregressive flow (transformer-MAF). The autoregressive structure mimicked the causal relationship between condition, action and crash outcome and the probability density functions are used to calculate the conditional action probability, crash probability and conditional crash probability. The predicted sequence is accurate and the estimated probability is reasonable under both traffic conflict context and normal interaction context and the conditional crash probability shows the effectiveness of evasive action to avoid crashes in a counterfactual experiment

Self-Diffusion in 2D Dusty Plasma Liquids: Numerical Simulation Results

We perform Brownian dynamics simulations for studying the self-diffusion in two-dimensional (2D) dusty plasma liquids, in terms of both mean-square displacement and velocity autocorrelation function (VAF). Super-diffusion of charged dust particles has been observed to be most significant at infinitely small damping rate $\gamma$ for intermediate coupling strength, where the long-time asymptotic behavior of VAF is found to be the product of $t^{-1}$ and $\exp{(-\gamma t)}$. The former represents the prediction of early theories in 2D simple liquids and the latter the VAF of a free Brownian particle. This leads to a smooth transition from super-diffusion to normal diffusion, and then to sub-diffusion with an increase of the damping rate. These results well explain the seemingly contradictory scattered in recent classical molecular dynamics simulations and experiments of dusty plasmas.Comment: 10 pages 5 figures, accepted by PR

Finite size effects on MπM_\pi in QCD from Chiral Perturbation Theory

We present a determination of the shift $M_\pi(L)-M_\pi$ due to the finite spatial box size $L$ by means of $N_f=2$ Chiral Perturbation Theory and L\"uscher's formula. The range of applicability of the chiral prediction is discussed.Comment: 3 pages, 3 figures, Lattice2002(spectrum