Nearly zero balance winery - riqualificazione ed ampliamento di una cantina vinicola a Terricciola (Pisa)

Pieve de’ Pitti è una realtà che, attraversando i secoli e sconfiggendo il trascorre del tempo, ci restituisce ancora oggi un frammento di storia carico di ricordi, significati e sapori. All’interno della tenuta, attorno al quale in tempi antichi nacque e si sviluppò un piccolo borgo, rimangono il Castello di Pava, la Villa costruita da Cosimo di Jacopo Pitti, e la cantina al cui interno attualmente trova albergo l’interno processo di produzione vinicola delle aree circostanti. Il processo perseguito punta a realizzare un’opera di riqualificazione del fabbricato attualmente ospitante la cantina stessa, mediante una riorganizzazione delle aree interne esistenti e la realizzazione di un ampliamento utile a chiudere il ciclo produttivo vinicolo, permettendo le fasi di imbottigliamento ed affinamento in loco (lavorazioni attualmente effettuate in separata sede). Tutto questo percorso si sviluppa aspirando al minor impatto ambientale possibile, architettonico ed energetico. Al fine di realizzare un fabbricato capace di ospitare un percorso produttivo altamente funzionale ed efficiente, contestualmente alla ricerca architettonica è stato effettuato uno studio dettagliato di tutti i processi della produzione enologica, per poi focalizzarsi particolarmente sulle fasi in cui è necessario un intervento impiantistico per il controllo delle temperature dei prodotti, definendo attrezzature e macchine frigorifere necessarie al dimensionamento e funzionamento del fabbricato. Si è inoltre indagato il legame con l’elemento “terra”, analizzandone le potenzialità energetiche cui far ricorso nelle progettazioni delle aree destinate alla realizzazione di cantine, ed inseguendo il più possibile l’appellativo di “ipogeo”, che le ricollega tanto alla tradizione storica quanto alla ricerca dell’integrazione paesaggistica. Definito il profilo progettuale, viene infine effettuato lo studio dell’efficacia di un intervento di ristrutturazione e miglioramento delle qualità termiche della porzione di involucro esistente, affiancandolo alla realizzazione di un ampliamento caratterizzato da un’elevata capacità di isolamento. Questa indagine si completa con l’analisi tre differenti scenari caratterizzati da diverse soluzioni impiantistiche, cercando la miglior resa economica e minor impatto ambientale in termini di consumi energetici ed emissione di CO2

The BLAST Survey of the Vela Molecular Cloud: Dynamical Properties of the Dense Cores in Vela-D

The Vela-D region, according to the nomenclature given by Murphy & May (1991), of the star forming complex known as the Vela Molecular Ridge (VMR), has been recently analyzed in details by Olmi et al. (2009), who studied the physical properties of 141 pre- and proto-stellar cold dust cores, detected by the ``Balloon-borne Large-Aperture Submillimeter Telescope'' (BLAST) during a much larger (55 sq. degree) Galactic Plane survey encompassing the whole VMR. This survey's primary goal was to identify the coldest, dense dust cores possibly associated with the earliest phases of star formation. In this work, the dynamical state of the Vela-D cores is analyzed. Comparison to dynamical masses of a sub-sample of the Vela-D cores estimated from the 13CO survey of Elia et al. (2007), is complicated by the fact that the 13CO linewidths are likely to trace the lower density intercore material, in addition to the dense gas associated with the compact cores observed by BLAST. In fact, the total internal pressure of these cores, if estimated using the 13CO linewidths, appears to be higher than the cloud ambient pressure. If this were the case, then self-gravity and surface pressure would be insufficient to bind these cores and an additional source of external confinement (e.g., magnetic field pressure) would be required. However, if one attempts to scale down the 13CO linewidths, according to the observations of high-density tracers in a small sample of sources, then most proto-stellar cores would result effectively gravitationally bound.Comment: This paper has 12 pages and 6 figures. Accepted for publication by the Astrophysical Journal on July 19, 201

Postpartum Ovarian Vein Thrombosis

Postpartum ovarian vein thrombosis carries a significant risk of morbidity and mortality if not recognized early and managed appropriately

Vitamin K2 supplementation blocks the beneficial effects of IFN-α-2b administered in the early stages of liver cancer development in rats

Objective: Vitamin K2, which is present in dairy products and has been recommended as a micronutrient supplement in humans, contains anticancer properties. Interferon (IFN)-α-2b administered during development of hepatic preneoplasia decreased both number and volume percentage of altered hepatic foci (AHF) by increasing apoptosis in the foci. The aim of this study was to evaluate the effects of IFN-α-2b treatment supplemented with vitamin K2 in the early stages of liver cancer development in rats. Methods: Adult male Wistar rats were subjected to a two-phase model of hepatocarcinogenesis (initiated-promoted [IP] group). Animals were divided into four groups: untreated (IP), IP treated with IFN-α-2b (6.5 × 105 U/kg), IP treated with vitamin K2 (10 mg/kg), and IP treated with both compounds. Results: The study results demonstrated that vitamin K2 blocked IFN-α-2b–induced reduction in size and volume of the altered hepatic foci and inhibited IFN-α-2b–induced apoptosis. Its inhibition of IFN-α-2b–induced apoptosis was mediated by increased levels of total hepatic Bcl-2 in rat preneoplastic livers. Conclusion: These findings demonstrate that supportive vitamin supplements or therapies are not always safe because they could put the life of patients treated with IFN-α-2b at risk.Fil: Vera, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lorenzetti, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lucci, Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; ArgentinaFil: Comanzo, Carla Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Ceballos Mancini, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Pisani, Gerardo Bruno. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; ArgentinaFil: Alvarez, María de Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; ArgentinaFil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; ArgentinaFil: Carrillo, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; Argentin

High-resolution TNG spectra of T Tauri stars. Near-IR GIANO observations of the young variables XZ Tauri and DR Tauri

Aims: We aim to characterise the star-disk interaction region in T Tauri stars that show photometric and spectroscopic variability. Methods: We used the GIANO instrument at the Telescopio Nazionale Galileo to obtain near-infrared high-resolution spectra (R 50 000) of XZ Tau and DR Tau, which are two actively accreting T Tauri stars classified as EXors. Equivalent widths and profiles of the observed features are used to derive information on the properties of the inner disk, the accretion columns, and the winds. Results: Both sources display composite H I line profiles, where contributions from both accreting gas and high-velocity winds can be recognised. These lines are progressively more symmetric and narrower with increasing upper energy which may be interpreted in terms of two components with different decrements or imputed to self-absorption effects. XZ Tau is observed in a relatively high state of activity with respect to literature observations. The variation of the He I 1.08 μm line blue-shifted absorption, in particular, suggests that the inner wind has undergone a dramatic change in its velocity structure, connected with a recent accretion event. DR Tau has a more stable wind as its He I 1.08 μm absorption does not show variations with time in spite of strong variability of the emission component. The IR veiling in the two sources can be interpreted as due to blackbody emission at temperatures of 1600 K and 2300 K for XZ Tau and DR Tau, respectively, with emitting areas 30 times larger than the central star. While for XZ Tau these conditions are consistent with emission from the inner rim of the dusty disk, the fairly high temperature inferred for DR Tau might suggest that its veiling originates from a thick gaseous disk located within the dust sublimation radius. Strong and broad metallic lines, mainly from C I and Fe I, are detected in XZ Tau, similar to those observed in other EXor sources during burst phases. At variance, DR Tau shows weaker and narrower metallic lines, despite its larger accretion luminosity. This suggests that accretion is not the only driver of metallic line excitation. Conclusions: The presented observations demonstrate the potential of wide-band, high-resolution near-IR spectroscopy to simultaneously probe the different phenomena that occur in the interaction region between the stellar magnetosphere and the accretion disk, thus providing hints on how these two structures are linked to each other

The BLAST Survey of the Vela Molecular Cloud: Physical Properties of the Dense Cores in Vela-D

The Balloon-borne Large-Aperture Submillimeter Telescope (BLAST) carried out a 250, 350 and 500 micron survey of the galactic plane encompassing the Vela Molecular Ridge, with the primary goal of identifying the coldest dense cores possibly associated with the earliest stages of star formation. Here we present the results from observations of the Vela-D region, covering about 4 square degrees, in which we find 141 BLAST cores. We exploit existing data taken with the Spitzer MIPS, IRAC and SEST-SIMBA instruments to constrain their (single-temperature) spectral energy distributions, assuming a dust emissivity index beta = 2.0. This combination of data allows us to determine the temperature, luminosity and mass of each BLAST core, and also enables us to separate starless from proto-stellar sources. We also analyze the effects that the uncertainties on the derived physical parameters of the individual sources have on the overall physical properties of starless and proto-stellar cores, and we find that there appear to be a smooth transition from the pre- to the proto-stellar phase. In particular, for proto-stellar cores we find a correlation between the MIPS24 flux, associated with the central protostar, and the temperature of the dust envelope. We also find that the core mass function of the Vela-D cores has a slope consistent with other similar (sub)millimeter surveys.Comment: Accepted for publication in the Astrophysical Journal. Data and maps are available at http://blastexperiment.info

Participation of 5-lipoxygenase and LTB4 in liver regeneration after partial hepatectomy

Regeneration is the unmatched liver ability for recovering its functional mass after tissue lost. Leukotrienes (LT) are a family of eicosanoids with the capacity of signaling to promote proliferation. We analyzed the impact of blocking LT synthesis during liver regeneration after partial hepatectomy (PH). Male Wistar rats were subjected to two-third PH and treated with zileuton, a specific inhibitor of 5-lipoxygenase (5-LOX). Our first find was a significant increment of intrahepatic LTB4 during the first hour after PH together with an increase in 5-LOX expression. Zileuton reduced hepatic LTB4 levels at the moment of hepatectomy and also inhibited the increase in hepatic LTB4. This inhibition produced a delay in liver proliferation as seen by decreased PCNA and cyclin D1 nuclear expression 24 h post-PH. Results also showed that hepatic LTB4 diminution by zileuton was associated with a decrease in NF-ĸB activity. Additionally, decreased hepatic LTB4 levels by zileuton affected the recruitment of neutrophils and macrophages. Non-parenchymal cells (NPCs) from zileuton-treated PH-rats displayed higher apoptosis than NPCs from PH control rats. In conclusion, the present work provides evidences that 5-LOX activation and its product LTB4 are involved in the initial signaling events for liver regeneration after PH and the pharmacological inhibition of this enzyme can delay the initial time course of the phenomenon.Fil: Lorenzetti, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Vera, Marina Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Ceballos Mancini, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Pisani, Gerardo Bruno. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; ArgentinaFil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Lucci, Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; ArgentinaFil: Comanzo, Carla Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Tordjmann, Thierry. Université Paris-Saclay; Francia. Institut National de la Santé et de la Recherche Médicale; FranciaFil: Carrillo, María Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; ArgentinaFil: Quiroga, Ariel Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; Argentina. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; ArgentinaFil: Alvarez, María de Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; Argentina. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; Argentin

Caratteristiche corporee e vibrazioni trasmesse: ricerca di una possibile correlazione

"\"Lo studio si propone, nell’ambito degli aspetti relativi alla sicurezza sul lavoro, con riferimento alla valutazione dei rischi da agenti fisici in generale e da vibrazioni trasmesse al corpo intero in particolare, di valutare la possibile correlazione esistente tra le vibrazioni trasmesse al corpo di un conducente di mezzi d’opera e le sue caratteristiche corporee principali quali altezza e peso. È noto infatti che l'esposizione umana a vibrazioni meccaniche può rappresentare un fattore di rischio rilevante per i lavoratori esposti. In particolare la direttiva 2002\\\/44\\\/CE del parlamento europeo sulle prescrizioni minime di sicurezza e di salute relative all’esposizione dei lavoratori ai rischi derivanti dagli agenti fisici (vibrazioni) sancisce l’obbligo a carico del responsabile dell’attività di valutare tale rischio espositivo con la determinazione della dose giornaliera. I riscontri sperimentali e i monitoraggi eseguiti su soggetti esposti in ambito estrattivo [1] e non solo [2], hanno evidenziato, in sede proprio di determinazione dei valori di esposizione, delle differenze anche sensibili per soggetti diversi nelle medesime condizioni operative. Stante dunque la riproposizione di medesime condizioni al contorno quali il tipo di macchinario sorgente, l’ambiente di lavoro, le caratteristiche temporali dell’esposizione, lo stile di guida del mezzo, è apparso naturale investigare sulle possibili cause di tali scostamenti espositivi. Il tentativo qui illustrato ha riguardato l’analisi di variabilità delle vibrazioni trasmesse al corpo intero in relazione alla costituzione corporea del soggetto esposto al fine di definire le modalità e dunque fornire una analisi quantitativa di tale variabilità rispetto appunto ad altezza e peso del soggetto stesso. In questo studio si è optato per una modellizzazione geostatistica del fenomeno espositivo [3]. In sostanza si è scelta una analisi che fornisse in uscita delle mappe a linee iso-accelerazione, in funzione della variazione di peso e altezza del soggetto per una determinata sorgente mantenuta costante ovvero le cui condizioni operative garantissero in linea generale una buona ripetibilità. Sulla base dunque di tali presupposti metodologici, si è impostata una campagna di rilevazione per una popolazione campione di sette individui di diversa altezza e peso e per ogni soggetto sono stati registrati nelle medesime condizioni operative, i valori di accelerazione associati ai tre assi principali X,Y, Z. Una volta poi acclarata la ripetibilità della sorgente, è stata studiata la variabilità del parametro in studio in funzione dei parametri soggettivi di altezza e peso. Il risultato è consistito dapprima nel verificare l’esistenza di tale correlazione e successivamente, sulla base di un modello geostatistico di variabilità assunto quale rappresentativo del fenomeno, nell’ottenere una stima dei valori espositivi a vibrazioni anche per soggetti di caratteristiche corporee incognite, ovvero diverse da quelle dei soggetti per i quali le misurazioni erano state effettuate. Alla luce dei risultati ottenuti è possibile affermare l’esistenza di tale correlazione e di riflesso l’adeguatezza del metodo geostatistico adottato per l’analisi del fenomeno. In sintesi dunque, è auspicabile ampliare la casistica di indagine sulla scorta della metodologia proposta, anche ampliando la consistenza della popolazione osservata al fine di corroborare le risultanze sperimentali disponibili e affinare i parametri della ricerca.\"""\"This study aims to assess how the whole body vibration of heavy vehicle driver are not only affected by the characteristics of the source, but also by the characteristics of the driver, in particular weight and height. To achieve this objective we use geostatistical modeling, the branch of statistics that studies the phenomena that are developed on space-based, starting from the information derived from their sampling. The study is highly experimental and innovative as we adapt the instrument, the geostatistical one, commonly used in spacial character phenomenon to a not-spacial phenomenon. In fact, we use the theory of geostatistics considering height and weight instead of spatial coordinates, and the amount of vibration transmitted to the whole body, as a regionalized variable. The decision to describe the phenomenon with geostatistical modeling, stems from having a limited number of samples and a difficult source to repeat, which makes the geostatistical suitable for this purpose. In fact, it is often used to study these phenomena, characterized by the limited availability of samples.. Human exposure to mechanical vibration can be a significant risk factor for exposed workers. Directive 2002\\\/44\\\/EC of the European Parliament 2002, which indicates the minimum health and safety requirements regarding the exposure of workers to risks arising from physical agents (vibration), states that risk assessment can be made essentially without measurements, based on appropriate information available from the manufacturer and\\\/or accredited databases or with measurements, in agreement with the measuring method stipulated by specific standards ISO-EN. Dealing with the evaluation methodology of the whole-body vibration based on the availability of information, operating specifications are provided, referring to the reference values. In order to use these values, the operating conditions for the evaluation, must be compatible with the specification of the reference values. For this reason, some information are declared: the type of machine, the model, the date of registration, and the operating conditions as the soil type, the style of driving, the workplace etc. These information are approximated , and are not referred to the body constitution of the drivers of the vehicle at the time of the measures, as if this factor couldn’t affect the measurement results . . Aim of this case study is to find some correlations among vibration and their transmission to the entire body. The goal has been reached, since the vibrations are influenced because of human body structure. Geostatistical modeling has been quite useful, even if there were not so many samples to get a full map of vibrations and their transmission to the entire body, above all for X,Y, Z axes; but for further studies, with more samples, it should be a very powerful technique. Measured vibrations intensities are not so lower than the limits value planned in law: X axe moves from 0.32 m\\\/s2 to 0.40 m\\\/s2, when the limit action value is 0.5 m\\\/s2, and the maximum admitted is 1,15 m\\\/s2. So this gap can’t be ignored. In our case study, the measured values are lower than the action limit, because they have been achieved in particular operative condition (the Loader was at a stop). So, if operative conditions were too close to limit action, the intensity of the vibration could make jump over these values, becoming very important for the worker safety.\"