98 research outputs found
2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry
Objectives: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. Background: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine CMR on a European level. Methods: Multi-centre, multi-national, and multi-ethnical registry with consecutive enrolment of patients in 57 European centres. Results: During the current observation 37788 doses of Gadolinium based contrast agent were administered to 37788 patients. The mean dose was 24.7 ml (range 5–80 ml), which is equivalent to 0.123 mmol/kg (range 0.01 - 0.3 mmol/kg). Forty-five acute adverse reactions due to contrast administration occurred (0.12 %). Most reactions were classified as mild (43 of 45) according to the American College of Radiology definition. The most frequent complaints following contrast administration were rashes and hives (15 of 45), followed by nausea (10 of 45) and flushes (10 of 45). The event rate ranged from 0.05 % (linear non-ionic agent gadodiamide) to 0.42 % (linear ionic agent gadobenate dimeglumine). Interestingly, we also found different event rates between the three main indications for CMR ranging from 0.05 % (risk stratification in suspected CAD) to 0.22 % (viability in known CAD). Conclusions: The current data indicate that the results of the earlier safety data hold true in this much larger multi-national and multi-ethnical population. Thus, the “off-label” use of Gadolinium based contrast in cardiovascular MR should be regarded as safe concerning the frequency, manifestation and severity of acute events
Detecting neutral hydrogen in emission at redshift z ~ 1
We use a large N-body simulation to examine the detectability of HI in
emission at redshift z ~ 1, and the constraints imposed by current observations
on the neutral hydrogen mass function of galaxies at this epoch. We consider
three different models for populating dark matter halos with HI, designed to
encompass uncertainties at this redshift. These models are consistent with
recent observations of the detection of HI in emission at z ~ 0.8. Whilst
detection of 21 cm emission from individual halos requires extremely long
integrations with existing radio interferometers, such as the Giant Meter Radio
Telescope (GMRT), we show that the stacked 21 cm signal from a large number of
halos can be easily detected. However, the stacking procedure requires accurate
redshifts of galaxies. We show that radio observations of the field of the
DEEP2 spectroscopic galaxy redshift survey should allow detection of the HI
mass function at the 5-12 sigma level in the mass range 10^(11.4) M_sun/h <
M_halo < 10^(12.5)M_sun/h, with a moderate amount of observation time. Assuming
a larger noise level that corresponds to an upper bound for the expected noise
for the GMRT, the detection significance for the HI mass function is still at
the 1.7-3 sigma level. We find that optically undetected satellite galaxies
enhance the HI emission profile of the parent halo, leading to broader wings as
well as a higher peak signal in the stacked profile of a large number of halos.
We show that it is in principle possible to discern the contribution of
undetected satellites to the total HI signal, even though cosmic variance
limitation make this challenging for some of our models.Comment: 14 pages, 9 figures, Submitted To MNRA
Total hip replacement for neck of femur fracture:comparing outcomes with matched elective cohort
Determinação da energia metabolizável de diferentes alimentos testados em codornas japonesas fêmeas
Produção e qualidade pós-colheita de cultivares de pereira nas condições subtropicais da região leste paulista
Silagem de capim-elefante (Pennisetum purpureum, Schum) com e sem acipin, associada a duas fontes protéicas na alimentação de bovinos em confinamento
Diagnosis of Leishmania infantum infection by Polymerase Chain Reaction in wild mammals
NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics
Xenarthrans – anteaters, sloths, and armadillos – have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with 24 domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, ten anteaters, and six sloths. Our dataset includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data-paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the south of the USA, Mexico, and Caribbean countries at the northern portion of the Neotropics, to its austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n=5,941), and Cyclopes sp. has the fewest (n=240). The armadillo species with the most data is Dasypus novemcinctus (n=11,588), and the least recorded for Calyptophractus retusus (n=33). With regards to sloth species, Bradypus variegatus has the most records (n=962), and Bradypus pygmaeus has the fewest (n=12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other datasets of Neotropical Series which will become available very soon (i.e. Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans dataset
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