Online tools facilities for historical earthquake data investigation

SVG can be an easy and effective solution in the historical earthquake data investigation when it comes to a very specific need not achievable using general purpose software. With a basic knowledge of web languages (HTML, Javascript and PHP) and commonly available server side software (Apache and not spatially-aware MySql) we succeded creating an interactive web-mapping tool for macroseismic data and a time-saver gazetteer management tool

The AHEAD Portal: A Gateway to European Historical Earthquake Data

The description of the seismicity of the European region is today fragmented into an increasing number of earthquake archives, databases, and catalogs related to individual countries or even to part of them. Therefore, the compilation of a comprehensive, European earthquake history requires dealing with a puzzle of partially overlapping, only partially public catalogs, the background of which is compiled according to varied schemes. One of the consequences is that earthquakes in the frontier areas are often interpreted in a conflicting way by the catalogs of the bordering countries. In the framework of the European Commission (EC), 2006–2010 Network of Research Infrastructures for European Seismology (NERIES) Project, the task of Networking Activity 4 (NA4) was defined precisely to conceive and develop solutions to bridge over these differences. NA4 promoted the cooperation among existing national online archives, and contributed establishing new regional online archives compiled according to common standards. As a result, a first release of the distributed European archive of historical earthquake data, for the time-window 1000–1899 and for the large earthquakes, was published in 2010. Special attention was devoted to retrieve the earthquake background information, that is, the results of historical earthquake investigation—referenced to as studies in the following -in terms of a paper, a report, a book chapter, a map, etc. As the most useful studies are those supplying a set of macroseismic data points (MDPs)- that is a list of localities (name and coordinates) with a macroseismic intensity assessment and the related macroseismic scale—a dedicated effort was addressed to make such data available. The Archive of Historical Earthquake Data (AHEAD) distributed archive was improved and updated in the frame of the 2010–2012 EC Project Seismic Hazard Harmonization in Europe (SHARE), Task 3.1 European earthquake database, with the contribution of a number of European institutions. For the time window 1000–1899, it was AHEAD (AHEAD Working Group) that supported the compilation of the SHARE European Earthquake Catalog (SHEEC; Stucchi et al., 2013). This paper describes the AHEAD portal (http://www.emidius.eu/AHEAD/; last accessed March 2014), and how it was conceived to network the local components of the distributed archive. Although local historical macroseismic databases usually supply one set of information for each earthquake, at a European scale an earthquake still might be described by several studies, available from different archives. The AHEAD portal inventories and gives access to multiple sets of information concerning each earthquake, and allows users to get comprehensive information about individual earthquakes, providing the answers to the following questions: 1. which sets of earthquake parameters (time, location, magnitude, magnitude type, maximum intensity, etc.) are available for each earthquake? 2. what is the background information, or supporting material, upon which each set of earthquake parameter determination is based

External Prolonged Electrocardiogram Monitoring in Unexplained Syncope and Palpitations: Results of the SYNARR-Flash Study

AIMS: SYNARR-Flash study (Monitoring of SYNcopes and/or sustained palpitations of suspected ARRhythmic origin) is an international, multicentre, observational, prospective trial designed to evaluate the role of external 4-week electrocardiogram (ECG) monitoring in clinical work-up of unexplained syncope and/or sustained palpitations of suspected arrhythmic origin. METHODS AND RESULTS: Consecutive patients were enrolled within 1 month after unexplained syncope or palpitations (index event) after being discharged from emergency room or hospitalization without a conclusive diagnosis. A 4-week ECG monitoring was obtained by external high-capacity loop recorder (SpiderFlash-T(®), Sorin) storing patient-activated and auto-triggered tracings. Diagnostic monitorings included (i) conclusive events with reoccurrence of syncope or palpitation with concomitant ECG recording (with/without arrhythmias) and (ii) events with asymptomatic predefined significant arrhythmias (sustained supraventricular or ventricular tachycardia, advanced atrio-ventricular block, sinus bradycardia 6 s). SYNARR-Flash study enrolled 395 patients (57.7% females, 56.9 ± 18.7 years, 28.1% with syncope, and 71.9% with palpitations) from 10 European centres. For syncope, the 4-week diagnostic yield was 24.5%, and predictors of diagnostic events were early start of recording (0-15 vs. >15 days after index event) (OR 6.2, 95% CI 1.3-29.6, P = 0.021) and previous history of supraventricular arrhythmias (OR 3.6, 95% CI 1.4-9.7, P = 0.018). For palpitations, the 4-week diagnostic yield was 71.6% and predictors of diagnostic events were history of recurrent palpitations (P < 0.001) and early start of recording (P = 0.001). CONCLUSION: The 4-week external ECG monitoring can be considered as first-line tool in the diagnostic work-up of syncope and palpitation. Early recorder use, history of supraventricular arrhythmia, and frequent previous events increased the likelihood of diagnostic events during the 4-week external ECG monitoring.info:eu-repo/semantics/publishedVersio

A WebGIS tool for the dissemination of earthquake data

In 2004 a new seismic hazard map of Italy (MPS Working Group, 2004) has been released by a task force that produced an amount of new or updated data, such as a new version of the earthquake catalogue (CPTI04; CPTI Working Group, 2004) and an updated seismogenic zonation. A set of WebGIS tools has been designed for the data dissemination to the scientific community and the general public. The design of the WebGIS tools focused first on the consultation of the DBM04 macroseismic database (DBM Working Group, 2005), which contains the macroseismic intensity data-points (IDP) of the earthquakes listed in the CPTI04 catalogue. The WebGIS tool design and development process had to fulfill: 1) simplicity, 2) responsiveness and 3) readiness for future extensions. The specific requirements for the macroseismic database consultation interface were: - data access by place and by earthquake; - IDP maps with queryable points; - data download in both tabular and map format; - easily upgradable content; - quick and user friendly interface

The relation of 12 lead ECG to the cardiac anatomy: The normal CineECG.

Abstract Background The interpretation of the 12‑lead ECG is notoriously difficult and requires experts to distinguish normal from abnormal ECG waveforms. ECG waveforms depend on body build and electrode positions, both often different in males and females. To relate the ECG waveforms to cardiac anatomical structures is even more difficult. The novel CineECG algorithm enables a direct projection of the 12‑lead ECG to the cardiac anatomy by computing the mean location of cardiac activity over time. The aim of this study is to investigate the cardiac locations of the CineECG derived from standard 12‑lead ECGs of normal subjects. Methods In this study we used 6525 12‑lead ECG tracings labelled as normal obtained from the certified Physionet PTB XL Diagnostic ECG Database to construct the CineECG. All 12 lead ECGs were analyzed, and then divided by age groups (18–29,30-39,40-49,50-59,60-69,70–100 years) and by gender (male/female). For each ECG, we computed the CineECG within a generic 3D heart/torso model. Based on these CineECG's, the average normal cardiac location and direction for QRS, STpeak, and TpeakTend segments were determined. Results The CineECG direction for the QRS segment showed large variation towards the left free wall, whereas the STT segments were homogeneously directed towards the septal/apical region. The differences in the CineECG location for the QRS, STpeak, and TpeakTend between the age and gender groups were relatively small (maximally 10 mm at end T-wave), although between the gender groups minor differences were found in the 4 chamber direction angles (QRS 4°, STpeak 5°, and TpeakTend 8°) and LAO (QRS 1°, STpeak 13°, and TpeakTend 30°). Conclusion CineECG demonstrated to be a feasible and pragmatic solution for ECG waveform interpretation, relating the ECG directly to the cardiac anatomy. The variations in depolarization and repolarization CineECG were small within this group of normal healthy controls, both in cardiac location as well as in direction. CineECG may enable an easier discrimination between normal and abnormal QRS and T-wave morphologies, reducing the amount of expert training. Further studies are needed to prove whether novel CineECG can significantly contribute to the discrimination of normal versus abnormal ECG tracings

HIV-1 Coreceptor Activity of CCR5 and Its Inhibition by Chemokines: Independence from G Protein Signaling and Importance of Coreceptor Downmodulation

AbstractHIV-1 infection requires the presence of specific chemokine receptors on CD4+ target cells to enable the fusion reactions involved in virus entry. CCR5 is a major fusion coreceptor for macrophage-tropic HIV-1 isolates. HIV-1 entry and fusion are mediated by the viral envelope glycoprotein (Env) and are inhibited by CCR5 ligands, but the mechanisms are unknown. Here, we test the role of G protein signaling and CCR5 surface downmodulation by two separate approaches: direct inactivation of CCR5 signaling by mutagenesis and inactivation of Gi-type G proteins with pertussis toxin. A CCR5 mutant lacking the last 45 amino acids of the cytoplasmic C-terminus (CCR5306) was created that was expressed on transfected cells at levels comparable to cells expressing CCR5 and displayed normal chemokine binding affinity. CCR5 ligands induced calcium flux and receptor downmodulation in cells expressing CCR5, but not in cells expressing CCR5306. Nevertheless, CCR5 or CCR5306, when coexpressed with CD4, supported comparable HIV-1 Env-mediated cell fusion. Consistent with this, treatment of CCR5-expressing cells with pertussis toxin completely blocked ligand-induced transient calcium flux, but did not affect Env-mediated cell fusion or HIV-1 infection. Also, pertussis toxin did not block chemokine inhibition of Env-mediated cell fusion or HIV-1 infection. However, chemokines inhibited Env-mediated cell fusion less efficiently for CCR5306than for CCR5. We conclude that the C-terminal domain of CCR5 is critical for G protein signaling and receptor downmodulation from the surface, but that neither function is required for CCR5 fusion coreceptor activity. The contrasting phenotypes of CCR5 and CCR5306suggest that coreceptor downmodulation and direct blockage of Env interaction sites both contribute to chemokine inhibition of HIV-1 infection

A WebGIS tool for the dissemination of earthquake data

In 2004 a new seismic hazard map of Italy (MPS Working Group, 2004) has been released by a task force that produced an amount of new or updated data, such as a new version of the earthquake catalogue (CPTI04; CPTI Working Group, 2004) and an updated seismogenic zonation. A set of WebGIS tools has been designed for the data dissemination to the scientific community and the general public. The design of the WebGIS tools focused first on the consultation of the DBM04 macroseismic database (DBM Working Group, 2005), which contains the macroseismic intensity data-points (IDP) of the earthquakes listed in the CPTI04 catalogue. The WebGIS tool design and development process had to fulfill: 1) simplicity, 2) responsiveness and 3) readiness for future extensions. The specific requirements for the macroseismic database consultation interface were: - data access by place and by earthquake; - IDP maps with queryable points; - data download in both tabular and map format; - easily upgradable content; - quick and user friendly interface

Migration of dendritic cells across blood and lymphatic endothelial barriers.

7openopenDel Prete A; Locati M; Otero K; Riboldi E; Mantovani A; Vecchi A; Sozzani S.DEL PRETE, Annalisa; Locati, M; Otero, K; Riboldi, E; Mantovani, A; Vecchi, A; Sozzani, Silvan