A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients

Acute kidney injury (AKI) is a syndrome with high incidence among the critically ill. Because the clinical variables and currently used biomarkers have failed to predict the individual susceptibility to AKI, candidate gene variants for the trait have been studied. Studies about genetic predisposition to AKI have been mainly underpowered and of moderate quality. We report the association study of 27 genetic variants in a cohort of Finnish critically ill patients, focusing on the replication of associations detected with variants in genes related to inflammation, cell survival, or circulation. In this prospective, observational Finnish Acute Kidney Injury (FINNAKI) study, 2647 patients without chronic kidney disease were genotyped. We defined AKI according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We compared severe AKI (Stages 2 and 3, n = 625) to controls (Stage 0, n = 1582). For genotyping we used iPLEX(TM) Assay (Agena Bioscience). We performed the association analyses with PLINK software, using an additive genetic model in logistic regression. Despite the numerous, although contradictory, studies about association between polymorphisms rs1800629 in TNFA and rs1800896 in IL10 and AKI, we found no association (odds ratios 1.06 (95% CI 0.89-1.28, p = 0.51) and 0.92 (95% CI 0.80-1.05, p = 0.20), respectively). Adjusting for confounders did not change the results. To conclude, we could not confirm the associations reported in previous studies in a cohort of critically ill patients

A Conceptual Framework for Personalization of Indoor Comfort Parameters Based on Office Workers’ Preferences

Part 1: Building Information ModelingInternational audiencePrevention of building-related illnesses and improving indoor air quality has become an emerging research area not only because of the comfort of workers in an office or the quality of the perceived air, but also because it can provide financial benefits to both employees and employers through a potential reduction in prolonged sick leaves. Therefore, building facility managers attempt to achieve the most comfortable and healthy environment conditions for the office workers. However, the parameters associated with achieved comfort vary from person to person as workers` preferences, as well physiological characteristics, are heterogeneous. In the ideal case, the indoor health parameters should be personalized based on individuals` feedback. This paper presents a computational framework for personalization of environmental parameters based on limited office workers’ feedback. We propose that by using current state of the art machine learning methods it is possible to learn the preference model of individuals, by employing both the limited feedback and the relevant literature on health-related symptoms. The framework is explained and discussed in a potential example scenario. Evaluation based on real data is left as a future work