12 research outputs found
The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections
Jason A. Roberts is funded by a Practitioner Fellowship from the National Health and Medical Research Council of Australia (APP1117065) and would like to acknowledge funding from the Australian National Health and Medical Research Council for Centre of Research Excellence (APP1099452)
Therapeutic drug monitoring by LC-MS-MS with special focus on anti-infective drugs
Liquid chromatography coupled to mass spectrometry nowadays plays an important role in the field of therapeutic drug monitoring (TDM), especially of new compounds for which no immunoassays are available. This paper reviews LC-MS(-MS) methods published recently for anti-infective drugs: antiretroviral drugs, other antiviral drugs, antibacterial drugs, antihelmintic drugs, antimalarial drugs, and other antiprotozoal drugs. An overview of the different methods is given, with special focus on selection of the internal standard and validation procedures