National demonstration project on epilepsy in Brazil./ Projeto Demonstrativo em Epilepsia no Brasil

Epilepsy is the most prevalent non-communicable serious neurological condition worldwide. Unfortunately, the majority of people with epilepsy in low-income countries do not receive appropriate treatment. Stigmatisation is the rule. In this setting, the World Health Organisation, the International League against Epilepsy and the International Bureau for Epilepsy launched the Global Campaign against Epilepsy in 1997. This entered its second phase in 2001 and as part of it has set up demonstration projects in the People's Republic of China, Zimbabwe, Senegal and, more recently, in Brazil. The objective of the demonstration projects is to show, through methodological evaluation, that it is possible to establish a model of treatment for people with epilepsy in primary health care settings. The Brazilian demonstration project has targeted regions in Campinas and Sao Jose do Rio Preto, both in Sao Paulo State. A task force has been established to assess strategies to expand this project nationwide. A epilepsia é a condição neurológica grave de maior prevalência no mundo. Infelizmente, a maioria dos pacientes com epilepsia nos países em desenvolvimento não recebem tratamento adequado e sofrem estigmatização pelo diagnóstico. Diante deste cenário, em 1997 foi lançada uma Campanha Global Contra Epilepsia liderada pela Organização Mundial da Saúde, a Internacional League Against Epilepsy, e International Bureau for Epilepsy. A Campanha entrou na sua segunda fase em 2001 com os projetos demonstrativos que estão em curso na China, Zimbábue, Senegal e recentemente no Brasil. A finalidade do projeto demonstrativo é mostrar através de avaliação metodológica que é possível estabelecer um modelo de atendimento integral aos pacientes com epilepsia. O projeto demonstrativo brasileiro tem como regiões de atuação Campinas e São José de Rio Preto. Uma Task Force foi instituída para estudar a expansão da atuação para outras áreas do paí

Adaptive Backstepping Fuzzy Control Based on Type-2 Fuzzy System

A novel indirect adaptive backstepping control approach based on type-2 fuzzy system is developed for a class of nonlinear systems. This approach adopts type-2 fuzzy system instead of type-1 fuzzy system to approximate the unknown functions. With type-reduction, the type-2 fuzzy system is replaced by the average of two type-1 fuzzy systems. Ultimately, the adaptive laws, by means of backstepping design technique, will be developed to adjust the parameters to attenuate the approximation error and external disturbance. According to stability theorem, it is proved that the proposed Type-2 Adaptive Backstepping Fuzzy Control (T2ABFC) approach can guarantee global stability of closed-loop system and ensure all the signals bounded. Compared with existing Type-1 Adaptive Backstepping Fuzzy Control (T1ABFC), as the advantages of handling numerical and linguistic uncertainties, T2ABFC has the potential to produce better performances in many respects, such as stability and resistance to disturbances. Finally, a biological simulation example is provided to illustrate the feasibility of control scheme proposed in this paper

Factors associated with failed treatment : an analysis of 121,744 women embarking on their first IVF cycles

Peer reviewedPublisher PD

Optical Identification of Infrared Space Observatory Far-Infrared Sources in the Lockman Hole Using a Deep Very Large Array 1.4 GHz Continuum Survey

By exploiting the far-infrared (FIR) and radio correlation, we have performed a likelihood-ratio analysis to identify optical counterparts to the FIR sources that have been found in an area of ~0.9 deg2 during the Infrared Space Observatory (ISO) deep FIR survey in the Lockman Hole. New ground-based observations have been conducted to build up the catalogs of radio and optical objects, which include a deep Very Large Array (VLA) observation at 1.4 GHz, optical R- and I-band imaging with the Subaru 8 m and University of Hawaii 2.2 m telescopes, and optical spectroscopy with the Keck II 10 m and WIYN 3.5 m telescopes. This work is based on FIR samples consisting of 116 and 20 sources selected with the criteria of FC(90 μm) ≥ 43 mJy and FC(170 μm) ≥ 102 mJy, respectively, where FC is the bias-corrected flux. Using the likelihood ratio analysis and the associated reliability, 44 FIR sources have been identified with radio sources. Optical confirmation of the 44 FIR/radio associations was then conducted using accurate radio positions. Redshifts have been obtained for 29 out of the 44 identified sources. One hyperluminous infrared galaxy (HyLIRG) with LFIR \u3e 1013 L and four ultraluminous infrared galaxies (ULIRGs) with LFIR = 1012–1013 L are identified in our sample, while the remaining 24 FIR galaxies have LFIR \u3c 1012 L. The space density of the FIR sources at z = 0.3–0.6 is 4.6 × 10-5 Mpc-3, which is 460 times larger than the local value, implying a rapid evolution of the ULIRG population. Most ISO FIR sources have L(1.4 GHz)/L(90 μm) similar to the star-forming galaxies Arp 220 and M82, indicating that star formation is the dominant mechanism for their FIR and radio luminosity. At least seven of our FIR sources show evidence for the presence of an active galactic nucleus (AGN) in optical emission lines, radio continuum excess, or X-ray activity. Three out of five (60%) of the ULIRGs/HyLIRGs are AGN galaxies, suggesting that the AGN fraction among the ULIRG/HyLIRG population may not change significantly between z ~ 0.5 and the present epoch. Five of the seven AGN galaxies are within the ROSAT X-ray survey field, and two are within the XMM-Newton survey fields. X-ray emission has been detected in only one source, 1EX030, which is optically classified as a quasar. The nondetection in the XMM-Newton 2–10 keV band suggests a very thick absorption column density of 3 × 1024 cm-2 or AV ~ 1200 mag obscuring the central source of the two AGN galaxies. Several sources have an extreme FIR luminosity relative to the optical R band, L(90 μm)/L(R) \u3e 500, which is rare even among the local ULIRG population. While source confusion or blending might offer an explanation in some cases, these observations may represent a new population of galaxies with an extreme amount of star formation in an undeveloped stellar system, i.e., formation of bulges or young elliptical galaxies

The Nature of the faint far-infrared extragalactic source population: Optical/NIR and radio follow-up observations of ISOPHOT deep-field sources using Keck, Subaru, and VLA telescopes

We report on optical and near-infrared (NIR) follow-up spectroscopy of faint far-infrared (FIR) sources found in our deep FIR survey by Kawara et al.Comment: 2 pages, 1 figure. To appear in the proceedings of "AGN Surveys" (IAU Colloquium 184

Mitochondrial DNA Copy Number Is Associated with Breast Cancer Risk

Mitochondrial DNA (mtDNA) copy number in peripheral blood is associated with increased risk of several cancers. However, data from prospective studies on mtDNA copy number and breast cancer risk are lacking. We evaluated the association between mtDNA copy number in peripheral blood and breast cancer risk in a nested case-control study of 183 breast cancer cases with pre-diagnostic blood samples and 529 individually matched controls among participants of the Singapore Chinese Health Study. The mtDNA copy number was measured using real time PCR. Conditional logistic regression analyses showed that there was an overall positive association between mtDNA copy number and breast cancer risk (Ptrend = 0.01). The elevated risk for higher mtDNA copy numbers was primarily seen for women with <3 years between blood draw and cancer diagnosis; ORs (95% CIs) for 2nd, 3rd, 4th, and 5th quintile of mtDNA copy number were 1.52 (0.61, 3.82), 2.52 (1.03, 6.12), 3.12 (1.31, 7.43), and 3.06 (1.25, 7.47), respectively, compared with the 1st quintile (Ptrend = 0.004). There was no association between mtDNA copy number and breast cancer risk among women who donated a blood sample ≥3 years before breast cancer diagnosis (Ptrend = 0.41). This study supports a prospective association between increased mtDNA copy number and breast cancer risk that is dependent on the time interval between blood collection and breast cancer diagnosis. Future studies are warranted to confirm these findings and to elucidate the biological role of mtDNA copy number in breast cancer risk. © 2013 Thyagarajan et al

FunSecKB: the Fungal Secretome KnowledgeBase

The Fungal Secretome KnowledgeBase (FunSecKB) provides a resource of secreted fungal proteins, i.e. secretomes, identified from all available fungal protein data in the NCBI RefSeq database. The secreted proteins were identified using a well evaluated computational protocol which includes SignalP, WolfPsort and Phobius for signal peptide or subcellular location prediction, TMHMM for identifying membrane proteins, and PS-Scan for identifying endoplasmic reticulum (ER) target proteins. The entries were mapped to the UniProt database and any annotations of subcellular locations that were either manually curated or computationally predicted were included in FunSecKB. Using a web-based user interface, the database is searchable, browsable and downloadable by using NCBI’s RefSeq accession or gi number, UniProt accession number, keyword or by species. A BLAST utility was integrated to allow users to query the database by sequence similarity. A user submission tool was implemented to support community annotation of subcellular locations of fungal proteins. With the complete fungal data from RefSeq and associated web-based tools, FunSecKB will be a valuable resource for exploring the potential applications of fungal secreted proteins

Hierarchical information clustering by means of topologically embedded graphs

We introduce a graph-theoretic approach to extract clusters and hierarchies in complex data-sets in an unsupervised and deterministic manner, without the use of any prior information. This is achieved by building topologically embedded networks containing the subset of most significant links and analyzing the network structure. For a planar embedding, this method provides both the intra-cluster hierarchy, which describes the way clusters are composed, and the inter-cluster hierarchy which describes how clusters gather together. We discuss performance, robustness and reliability of this method by first investigating several artificial data-sets, finding that it can outperform significantly other established approaches. Then we show that our method can successfully differentiate meaningful clusters and hierarchies in a variety of real data-sets. In particular, we find that the application to gene expression patterns of lymphoma samples uncovers biologically significant groups of genes which play key-roles in diagnosis, prognosis and treatment of some of the most relevant human lymphoid malignancies.Comment: 33 Pages, 18 Figures, 5 Table

Branch Mode Selection during Early Lung Development

Many organs of higher organisms, such as the vascular system, lung, kidney, pancreas, liver and glands, are heavily branched structures. The branching process during lung development has been studied in great detail and is remarkably stereotyped. The branched tree is generated by the sequential, non-random use of three geometrically simple modes of branching (domain branching, planar and orthogonal bifurcation). While many regulatory components and local interactions have been defined an integrated understanding of the regulatory network that controls the branching process is lacking. We have developed a deterministic, spatio-temporal differential-equation based model of the core signaling network that governs lung branching morphogenesis. The model focuses on the two key signaling factors that have been identified in experiments, fibroblast growth factor (FGF10) and sonic hedgehog (SHH) as well as the SHH receptor patched (Ptc). We show that the reported biochemical interactions give rise to a Schnakenberg-type Turing patterning mechanisms that allows us to reproduce experimental observations in wildtype and mutant mice. The kinetic parameters as well as the domain shape are based on experimental data where available. The developed model is robust to small absolute and large relative changes in the parameter values. At the same time there is a strong regulatory potential in that the switching between branching modes can be achieved by targeted changes in the parameter values. We note that the sequence of different branching events may also be the result of different growth speeds: fast growth triggers lateral branching while slow growth favours bifurcations in our model. We conclude that the FGF10-SHH-Ptc1 module is sufficient to generate pattern that correspond to the observed branching modesComment: Initially published at PLoS Comput Bio

No difference in stroke knowledge between Korean adherents to traditional and western medicine – the AGE study: an epidemiological study

BACKGROUND: Effective stroke intervention and risk reduction depend on the general public's awareness and knowledge of stroke. In Korea, where both traditional Oriental medicine and Western medicine are practiced, estimates of the general public's awareness and knowledge of stroke are poor. The present study sought to describe the inception cohort of the Ansan Geriatric Study (AGE study) and to determine baseline stroke awareness and preferred medical treatment for stroke in this Korean sample. METHODS: A total of 2,767 subjects selected randomly from the Ansan Geriatric Study in South Korea were questioned about stroke. Their answers were compared with their sociodemographic data and other variables. RESULTS: Only 44.8% of participants correctly identified stroke as a vascular disease in the human brain. Sudden numbness or weakness was the most frequently identified stroke warning sign (60.2%). Hypertension (66.7%) and mental stress (62.2%) were most frequently identified as stroke risk factors. The contributions of diabetes mellitus and cardiovascular disease to stroke were underestimated; they were identified as risk factors by 28.3% and 18.6% of participants, respectively. The predictors for poor knowledge of stroke warning signs and risk factors were similar irrespective of preference for Western or Oriental medical treatment, and included those with lower levels of education and inaccurate definition of stroke. Television and radio (40.3%) were the most frequent sources of stroke information for both groups. CONCLUSION: This study shows that knowledge of stroke is similar among Koreans with preferences for either Western or Oriental medical treatment and that misunderstandings about stroke are common among the Korean elderly. In order to prevent and manage stroke effectively, public health education regarding basic concepts of stroke is necessary. This should target those with a lower level of education and a misunderstanding of the definition of stroke