A Strandell

A Templeton

Abha Maheshwari

AM Stolwijk

AP Ferraretti

B Maugey-Laulom

CC Hunault

CH Syrop

DA Lawlor

E Hauzman

G Zou

Guy Brock

Jill Mollison

JK Min

K Ferlitsch

L Sabatini

LA McNutt

LD Ottosen

LF Bancsi

LL van Loendersloot

LL Van Loendersloot

MH van der Gaast

N Johnson

R Hart

S Greenland

Siladitya Bhattacharya

SK Sunkara

SM Ebbesen

SM Nelson

V Sharma

YA Wang

PLoS ONE

English

PubMed

Bhattacharya, Siladitya

Maheshwari, Abha

Mollison, Jill

Aberdeen University Research

Factors associated with failed treatment : an analysis of 121,744 women embarking on their first IVF cycles

In-vitro fertilization (IVF) is the treatment of choice for unresolved infertility. It comprises a number of key steps, each of which has to be negotiated before the next is attempted, but the factors which are associated with failure at each stage have not been reported. We analyzed anonymised national data on women undergoing their first fresh autologous IVF and intracytoplasmic sperm injection (ICSI) cycle in the United Kingdom between 2000 and 2007 to predict factors associated with overall lack of livebirth as well as the chance of non-progress at different stages of an IVF cycle. A total of 121,744 women were included in this analysis. Multivariable models underlined the importance of increased female age and duration of infertility, lack of previous pregnancy, and a diagnosis of tubal or male factor infertility in predicting the risk of not having a live birth in an IVF treatment. At each stage, a woman’s chance of proceeding to the next stage of IVF treatment is affected by increased age and duration of infertility. The intention to use intra-cytoplasmic sperm injection (ICSI) is associated with a decreased risk of treatment failure in women starting an IVF cycle (RR 0.93, 99% CI 0.92, 0.94) but this association is reversed at a later stage once fertilisation has been confirmed (RR=1.01, 99%CI 1.00, 1.03). Female age is a key predictor of failure to have a livebirth following IVF as well as the risk of poor performance at each stage of treatment. While increased duration of infertility is also associated with worse outcomes at every stage, its impact appears to be less influential. Women embarking on ICSI treatment for male factor infertility have a lower chance of treatment failure but this does not appear to be due to increased chances of implantation of ICSI embryos

Bhattacharya Siladitya

Maheshwari Abha

Mollison Jill

Public Library of Science (PLOS)

Factors Associated with Failed Treatment: an Analysis of 121,744 Women Embarking on Their First IVF Cycles

Online Research @ Cardiff

Factors associated with failed treatment: an analysis of 121,744 women embarking on their first IVF cycles

Crossref

BACKGROUND: In-vitro fertilization (IVF) is the treatment of choice for unresolved infertility. It comprises a number of key steps, each of which has to be negotiated before the next is attempted, but the factors which are associated with failure at each stage have not been reported. METHODS AND FINDINGS: We analyzed anonymised national data on women undergoing their first fresh autologous IVF and intracytoplasmic sperm injection (ICSI) cycle in the United Kingdom between 2000 and 2007 to predict factors associated with overall lack of livebirth as well as the chance of non-progress at different stages of an IVF cycle. A total of 121,744 women were included in this analysis. Multivariable models underlined the importance of increased female age and duration of infertility, lack of previous pregnancy, and a diagnosis of tubal or male factor infertility in predicting the risk of not having a live birth in an IVF treatment. At each stage, a woman's chance of proceeding to the next stage of IVF treatment is affected by increased age and duration of infertility. The intention to use intra-cytoplasmic sperm injection (ICSI) is associated with a decreased risk of treatment failure in women starting an IVF cycle (RR 0.93, 99% CI 0.92, 0.94) but this association is reversed at a later stage once fertilisation has been confirmed (RR=1.01, 99%CI 1.00, 1.03). CONCLUSIONS: Female age is a key predictor of failure to have a livebirth following IVF as well as the risk of poor performance at each stage of treatment. While increased duration of infertility is also associated with worse outcomes at every stage, its impact appears to be less influential. Women embarking on ICSI treatment for male factor infertility have a lower chance of treatment failure but this does not appear to be due to increased chances of implantation of ICSI embryos

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Factors associated with failed treatment: an analysis of 121,744 women embarking on their first IVF cycles.

http://dx.doi.org/10.1371/journal.pone.0082249

Factors associated with failed treatment : an analysis of 121,744 women embarking on their first IVF cycles

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Aberdeen University Research

Public Library of Science (PLOS)

Online Research @ Cardiff

Crossref

Directory of Open Access Journals