Emerging roles of ATF2 and the dynamic AP1 network in cancer

Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.Fil: Lopez Bergami, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Lau, Eric . Burnham Institute for Medical Research; Estados UnidosFil: Ronai, Zeev . Burnham Institute for Medical Research; Estados Unido

A Neuroergonomics Approach to Measure Pilot’s Cognitive Incapacitation in the Real World with EEG

Mental overload and mental fatigue are two degraded cognitive states that are known to promote cognitive incapacitation. We adopted a neuroergonomics approach to investigate these states that remain difficult to induce under la-boratory settings thus impeding their measurement. Two experiments were conducted under real flight conditions to respectively measure the electro-physiological correlates of mental fatigue and mental overload with a 32 chan-nel-dry EEG system. Our findings revealed that the occurrence of mental fatigue was related to higher theta and alpha band power. Mental overload was associ-ated with higher beta band power over frontal sites. We performed single trial classification to detect mental fatigue and over-load states. Classification accu-racy reached 76.9% and 89.1%, respectively, in discriminating mental fatigue vs. no fatigue and mental overload vs. low-high load. These preliminary results provide evidence for the feasibility of detecting neural correlates of cognitive fatigue and load during real flight conditions and provide promising perspec-tives on the implementation of neuroadaptive technology especially in the con-text of single pilot-operation

Designing Socio-Technical Systems: A Multi-team Case Study

Technical system design processes are typically based on systems engineering vee models where designers move between functional and physical domains as they develop detailed designs of the overall system and its sub-systems and component parts. The movements between the functional and physical domains are informed by the core activities of any design process: synthesis, description, analysis and simulation, and decision-making. However, delivering socio-technical systems design mindsets, such as those needed to design multi-team systems, requires a new branch of systems science that integrates human behavior into system behavior. Design processes built on such a science would allow system designers to compare alternative solutions in terms of their anticipated performance and consider different options with respect to functions carried out by humans and machines. In this chapter we use a systems design process vee model and apply it to a case study that involves the design of a multi-team customer service system. Both the application of the vee model (i.e., the proposed design process) and the results of its application (i.e., the multi-team customer service system) can be regarded as socio-technical systems and are used to illustrate and elaborate on Clegg’s (Appl Ergon 31(5):463–477, 2000) socio-technical principles for system design. On this basis, we provide a practical framework for designing socio-technical systems and identify requirements for developing future methods and tools to support this process