Predominant cultivable subgingival flora of renal transplant recipients

postprin

Preemptive regression test scheduling strategies: a new testing approach to thriving on the volatile service environments

A workflow-based web service may use ultra-late binding to invoke external web services to concretize its implementation at run time. Nonetheless, such external services or the availability of recently used external services may evolve without prior notification, dynamically triggering the workflow-based service to bind to new replacement external services to continue the current execution. Any integration mismatch may cause a failure. In this paper, we propose Preemptive Regression Testing (PRT), a novel testing approach that addresses this adaptive issue. Whenever such a late-change on the service under regression test is detected, PRT preempts the currently executed regression test suite, searches for additional test cases as fixes, runs these fixes, and then resumes the execution of the regression test suite from the preemption point. © 2012 IEEE |postprin

Diffusion tensor imaging for the evaluation of treatment-induced neurotoxicity in childhood medulloblastoma

published_or_final_versio

Diffusion tensor MR imaging in the evaluation of Wallerian degeneration in pediatric strokes: work-in-progress

Poster Session - Pediatric Brain MR Imaging: no. 2090We use DTI to detect and quantify Wallerian degeneration (WD) in pediatric MCA strokes. Fractional anisotropy (FA) and mean diffusivity (MD)of the infarction, ipsilateral internal capsule (PLIC) and cerebral peduncle (CP) were measured in nine children and compared to the matched contralateral side. WD was characterized by statistically significant differences in FA, but not MD, of the ipsilateral PLIC and CP compared to normal side. FA was reduced in all children, whilst corresponding hyperintense signals on T2W were seen in five children. DTI is more sensitive than conventional MRI and can be used to detect and quantify WD.published_or_final_versio

Periodontal Risk Spider-web for periodontal assessment in Hong Kong Chinese

published_or_final_versio

Relative expression of IL-1beta/IL-10 mRNA in periodontal health and disease

published_or_final_versio

IL-1β, TNF-α and IL-10 mRNA expression in advanced chronic periodontitis

published_or_final_versio

The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice

A novel avian influenza virus H7N9 infection occurred among human populations since 2013. Although the lack of sustained human-to-human transmission limited the epidemics caused by H7N9, the late presentation of most patients and the emergence of neuraminidase-resistant strains made the development of novel antiviral strategy against H7N9 in urgent demands. In this study, we evaluated the potential of pamidronate, a pharmacological phosphoantigen that can specifically boost human Vδ2-T-cell, on treating H7N9 virus-infected humanized mice. Our results showed that intraperitoneal injection of pamidronate could potently decrease the morbidity and mortality of H7N9-infected mice through controlling both viral replication and inflammation in affected lungs. More importantly, pamidronate treatment starting from 3 days after infection could still significantly ameliorate the severity of diseases in infected mice and improve their survival chance, whereas orally oseltamivir treatment starting at the same time showed no therapeutic effects. As for the mechanisms underlying pamidronate-based therapy, our in vitro data demonstrated that its antiviral effects were partly mediated by IFN-γ secreted from human Vδ2-T cells. Meanwhile, human Vδ2-T cells could directly kill virus-infected host cells in a perforin-, granzyme B- and CD137-dependent manner. As pamidronate has been used for osteoporosis treatment for more than 20 years, pamidronate-based therapy represents for a safe and readily available option for clinical trials to treat H7N9 infection.published_or_final_versio

New Experimental Limits on Macroscopic Forces Below 100 Microns

Results of an experimental search for new macroscopic forces with Yukawa range between 5 and 500 microns are presented. The experiment uses 1 kHz mechanical oscillators as test masses with a stiff conducting shield between them to suppress backgrounds. No signal is observed above the instrumental thermal noise after 22 hours of integration time. These results provide the strongest limits to date between 10 and 100 microns, improve on previous limits by as much as three orders of magnitude, and rule out half of the remaining parameter space for predictions of string-inspired models with low-energy supersymmetry breaking. New forces of four times gravitational strength or greater are excluded at the 95% confidence level for interaction ranges between 200 and 500 microns.Comment: 25 Pages, 7 Figures: Minor Correction

The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice

A novel avian influenza virus H7N9 infection occurred among human populations since 2013. Although the lack of sustained human-to-human transmission limited the epidemics caused by H7N9, the late presentation of most patients and the emergence of neuraminidase-resistant strains made the development of novel antiviral strategy against H7N9 in urgent demands. In this study, we evaluated the potential of pamidronate, a pharmacological phosphoantigen that can specifically boost human Vδ2-T-cell, on treating H7N9 virus-infected humanized mice. Our results showed that intraperitoneal injection of pamidronate could potently decrease the morbidity and mortality of H7N9-infected mice through controlling both viral replication and inflammation in affected lungs. More importantly, pamidronate treatment starting from 3 days after infection could still significantly ameliorate the severity of diseases in infected mice and improve their survival chance, whereas orally oseltamivir treatment starting at the same time showed no therapeutic effects. As for the mechanisms underlying pamidronate-based therapy, our in vitro data demonstrated that its antiviral effects were partly mediated by IFN-γ secreted from human Vδ2-T cells. Meanwhile, human Vδ2-T cells could directly kill virus-infected host cells in a perforin-, granzyme B- and CD137-dependent manner. As pamidronate has been used for osteoporosis treatment for more than 20 years, pamidronate-based therapy represents for a safe and readily available option for clinical trials to treat H7N9 infection.published_or_final_versio