5,302 research outputs found
Preemptive regression test scheduling strategies: a new testing approach to thriving on the volatile service environments
A workflow-based web service may use ultra-late binding to invoke external web services to concretize its implementation at run time. Nonetheless, such external services or the availability of recently used external services may evolve without prior notification, dynamically triggering the workflow-based service to bind to new replacement external services to continue the current execution. Any integration mismatch may cause a failure. In this paper, we propose Preemptive Regression Testing (PRT), a novel testing approach that addresses this adaptive issue. Whenever such a late-change on the service under regression test is detected, PRT preempts the currently executed regression test suite, searches for additional test cases as fixes, runs these fixes, and then resumes the execution of the regression test suite from the preemption point. © 2012 IEEE
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Diffusion tensor imaging for the evaluation of treatment-induced neurotoxicity in childhood medulloblastoma
published_or_final_versio
Diffusion tensor MR imaging in the evaluation of Wallerian degeneration in pediatric strokes: work-in-progress
Poster Session - Pediatric Brain MR Imaging: no. 2090We use DTI to detect and quantify Wallerian degeneration (WD) in pediatric MCA strokes. Fractional anisotropy (FA) and mean diffusivity (MD)of the
infarction, ipsilateral internal capsule (PLIC) and cerebral peduncle (CP) were measured in nine children and compared to the matched contralateral side. WD
was characterized by statistically significant differences in FA, but not MD, of the ipsilateral PLIC and CP compared to normal side. FA was reduced in all
children, whilst corresponding hyperintense signals on T2W were seen in five children. DTI is more sensitive than conventional MRI and can be used to detect
and quantify WD.published_or_final_versio
Periodontal Risk Spider-web for periodontal assessment in Hong Kong Chinese
published_or_final_versio
Relative expression of IL-1beta/IL-10 mRNA in periodontal health and disease
published_or_final_versio
IL-1β, TNF-α and IL-10 mRNA expression in advanced chronic periodontitis
published_or_final_versio
The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice
A novel avian influenza virus H7N9 infection occurred among human populations since 2013. Although the lack of sustained human-to-human transmission limited the epidemics caused by H7N9, the late presentation of most patients and the emergence of neuraminidase-resistant strains made the development of novel antiviral strategy against H7N9 in urgent demands. In this study, we evaluated the potential of pamidronate, a pharmacological phosphoantigen that can specifically boost human Vδ2-T-cell, on treating H7N9 virus-infected humanized mice. Our results showed that intraperitoneal injection of pamidronate could potently decrease the morbidity and mortality of H7N9-infected mice through controlling both viral replication and inflammation in affected lungs. More importantly, pamidronate treatment starting from 3 days after infection could still significantly ameliorate the severity of diseases in infected mice and improve their survival chance, whereas orally oseltamivir treatment starting at the same time showed no therapeutic effects. As for the mechanisms underlying pamidronate-based therapy, our in vitro data demonstrated that its antiviral effects were partly mediated by IFN-γ secreted from human Vδ2-T cells. Meanwhile, human Vδ2-T cells could directly kill virus-infected host cells in a perforin-, granzyme B- and CD137-dependent manner. As pamidronate has been used for osteoporosis treatment for more than 20 years, pamidronate-based therapy represents for a safe and readily available option for clinical trials to treat H7N9 infection.published_or_final_versio
New Experimental Limits on Macroscopic Forces Below 100 Microns
Results of an experimental search for new macroscopic forces with Yukawa
range between 5 and 500 microns are presented. The experiment uses 1 kHz
mechanical oscillators as test masses with a stiff conducting shield between
them to suppress backgrounds. No signal is observed above the instrumental
thermal noise after 22 hours of integration time. These results provide the
strongest limits to date between 10 and 100 microns, improve on previous limits
by as much as three orders of magnitude, and rule out half of the remaining
parameter space for predictions of string-inspired models with low-energy
supersymmetry breaking. New forces of four times gravitational strength or
greater are excluded at the 95% confidence level for interaction ranges between
200 and 500 microns.Comment: 25 Pages, 7 Figures: Minor Correction
The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice
A novel avian influenza virus H7N9 infection occurred among human populations since 2013. Although the lack of sustained human-to-human transmission limited the epidemics caused by H7N9, the late presentation of most patients and the emergence of neuraminidase-resistant strains made the development of novel antiviral strategy against H7N9 in urgent demands. In this study, we evaluated the potential of pamidronate, a pharmacological phosphoantigen that can specifically boost human Vδ2-T-cell, on treating H7N9 virus-infected humanized mice. Our results showed that intraperitoneal injection of pamidronate could potently decrease the morbidity and mortality of H7N9-infected mice through controlling both viral replication and inflammation in affected lungs. More importantly, pamidronate treatment starting from 3 days after infection could still significantly ameliorate the severity of diseases in infected mice and improve their survival chance, whereas orally oseltamivir treatment starting at the same time showed no therapeutic effects. As for the mechanisms underlying pamidronate-based therapy, our in vitro data demonstrated that its antiviral effects were partly mediated by IFN-γ secreted from human Vδ2-T cells. Meanwhile, human Vδ2-T cells could directly kill virus-infected host cells in a perforin-, granzyme B- and CD137-dependent manner. As pamidronate has been used for osteoporosis treatment for more than 20 years, pamidronate-based therapy represents for a safe and readily available option for clinical trials to treat H7N9 infection.published_or_final_versio
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