Convergent cultural evolution of continuers (mhmm)

Continuers —words like mm, mmhm, uhum and the like— are among the most frequent types of responses in conversation. They play a key role in joint action coordination by showing positive evidence of understanding and scaffolding narrative delivery. Here we investigate the hypothesis that their functional importance along with their conversational ecology places selective pressures on their form and may lead to cross-linguistic similarities through convergent cultural evolution. We compare continuer tokens in linguistically diverse conversational corpora and find languages make available highly similar forms. We then approach the causal mechanism of convergent cultural evolution using exemplar modelling, simulating the process by which a combination of effort minimization and functional specialization may push continuers to a particular region of phonological possibility space. By combining comparative linguistics and computational modelling we shed new light on the question of how language structure is shaped by and for social interaction

Induced pseudoscalar form factor of the nucleon at two-loop order in chiral perturbation theory

We calculate the imaginary part of the induced pseudoscalar form factor of the nucleon $G_P(t)$ in the framework of two-loop heavy baryon chiral perturbation theory. The effect of the calculated three-pion continuum on the pseudoscalar constant $g_P = (m_\mu/2M) G_P(t=-0.877m_\mu^2)$ measurable in ordinary muon capture $\mu^-p\to \nu_\mu n$ turns out to be negligibly small. Possible contributions from counterterms at two-loop order are numerically smaller than the uncertainty of the dominant pion-pole term proportional to the pion-nucleon coupling constant $g_{\pi N}= 13.2\pm 0.2$. We conclude that a sufficiently accurate representation of the induced pseudoscalar form factor of the nucleon at low momentum transfers $t$ is given by the sum of the pion-pole term and the Adler-Dothan-Wolfenstein term: $G_P(t) = 4g_{\pi N} M f_\pi/ (m_\pi^2 -t)- 2g_A M^2 /3$, with $= (0.44 \pm 0.02)$ fm$^2$ the axial mean square radius of the nucleon.Comment: 6 pages, 2 figures, accepted for publication in Physical Review

The pion charge radius from charged pion electroproduction

We analyze a low-energy theorem of threshold pion electroproduction which allows one to determine the charge radius of the pion. We show that at the same order where the radius appears, pion loops induce a correction to the momentum dependence of the longitudinal dipole amplitude $L_{0+}^{(-)}$. This model-independent correction amounts to an increase of the pion charge radius squared from the electroproduction data by about 0.26~fm$^2$. It sheds light on the apparent discrepancy between the recent determination of the pion radius from electroproduction data and the one based on pion-electron scattering.Comment: 3 pp, REVTeX, uses eps

Pion photo- and electroproduction and the partially-conserved axial current

The relevance of the axial current for pion production processes off the nucleon with real or virtual photons is revisited. Employing the hypothesis of a partially conserved axial current (PCAC), it is shown that, when all of the relevant contributions are taken into account, PCAC does not provide any additional constraint for threshold production processes that goes beyond the Goldberger-Treiman relation. In particular, it is shown that pion electroproduction processes at threshold cannot be used to extract any information regarding the weak axial form factor. The relationships found in previous investigations are seen to be an accident of the approximations usually made in this context.Comment: 4 pages, 3 figures; typos corrected; references updated; some rewording; conclusions unchange

A multi-mRNA host-response molecular blood test for the diagnosis and prognosis of acute infections and sepsis: Proceedings from a clinical advisory panel

Current diagnostics are insufficient for diagnosis and prognosis of acute infections and sepsis. Clinical decisions including prescription and timing of antibiotics, ordering of additional diagnostics and level-of-care decisions rely on understanding etiology and implications of a clinical presentation. Host mRNA signatures can differentiate infectious from noninfectious etiologies, bacterial from viral infections, and predict 30-day mortality. The 29-host-mRNA blood-based InSe

Evaluation of the cobas Cdiff Test for Detection of Toxigenic Clostridium difficile in Stool Samples

Nucleic acid amplification tests (NAATs) are reliable tools for the detection of toxigenic Clostridium difficile from unformed (liquid or soft) stool samples. The objective of this study was to evaluate performance of the cobas Cdiff test on the cobas 4800 system using prospectively collected stool specimens from patients suspected of having C. difficile infection (CDI). The performance of the cobas Cdiff test was compared to the results of combined direct and broth-enriched toxigenic culture methods in a large, multicenter clinical trial. Additional discrepancy analysis was performed by using the Xpert C. difficile Epi test. Sample storage was evaluated by using contrived and fresh samples before and after storage at -20°C. Testing was performed on samples from 683 subjects (306 males and 377 females); 113 (16.5%) of 683 subjects were positive for toxigenic C. difficile by direct toxigenic culture, and 141 of 682 subjects were positive by using the combined direct and enriched toxigenic culture method (reference method), for a prevalence rate of 20.7%. The sensitivity and specificity of the cobas Cdiff test compared to the combined direct and enriched culture method were 92.9% (131/141; 95% confidence interval [CI], 87.4% to 96.1%) and 98.7% (534/541; 95% CI, 97.4% to 99.4%), respectively. Discrepancy analysis using results for retested samples from a second NAAT (Xpert C. difficile/Epi test; Cepheid, Sunnyvale, CA) found no false-negative and 4 false-positive cobas Cdiff test results. There was no difference in positive and negative results in comparisons of fresh and stored samples. These results support the use of the cobas Cdiff test as a robust aid in the diagnosis of CDI

Separated cross sections in \pi^0 electroproduction at threshold at Q^2 = 0.05 GeV^2/c^2

The differential cross sections \sigma_0=\sigma_T+\epsilon \sigma_L, \sigma_{LT}, and \sigma_{TT} of \pi^0 electroproduction from the proton were measured from threshold up to an additional center of mass energy of 40 MeV, at a value of the photon four-momentum transfer of Q^2= 0.05 GeV^2/c^2 and a center of mass angle of \theta=90^\circ. By an additional out-of-plane measurement with polarized electrons \sigma_{LT'} was determined. This showed for the first time the cusp effect above the \pi^+ threshold in the imaginary part of the s-wave. The predictions of Heavy Baryon Chiral Perturbation Theory are in disagreement with these data. On the other hand, the data are somewhat better predicted by the MAID phenomenological model and are in good agreement with the dynamical model DMT.Comment: 6 pages, 4 figure

The f_LT Response Function of D(e,e'p)n at Q^2=0.33(GeV/c)^2

The interference response function f_LT (R_LT) of the D(e,e'p)n reaction has been determined at squared four-momentum transfer Q^2 = 0.33 (GeV/c)^2 and for missing momenta up to p_miss= 0.29 (GeV/c). The results have been compared to calculations that reproduce f_LT quite well but overestimate the cross sections by 10 - 20% for missing momenta between 0.1 (GeV/c) and 0.2 (GeV/c) .Comment: 12 Pages, 10 figure

A Transcriptomic Severity Classifier IMX-SEV-3b to Predict Mortality in Intensive Care Unit Patients with COVID-19:A Prospective Observational Pilot Study

The prediction of disease outcomes in COVID-19 patients in the ICU is of critical importance, and the examination of host gene expressions is a promising tool. The 29-host mRNA Inflam-matix-Severity-3b (IMX-SEV-3b) classifier has been reported to predict mortality in emergency department COVID-19 patients and surgical ICU patients. The accuracy of the IMX-SEV-3b in predicting mortality in COVID-19 patients admitted to the ICU is yet unknown. Our aim was to investigate the accuracy of the IMX-SEV-3b in predicting the ICU mortality of COVID-19 patients. In addition, we assessed the predictive performance of routinely measured biomarkers and the Sequential Organ Failure Assessment (SOFA) score as well. This was a prospective observational study enrolling COVID-19 patients who received mechanical ventilation on the ICU of the Erasmus MC, the Netherlands. The IMX-SEV-3b scores were generated by amplifying 29 host response genes from blood collected in PAXgene® Blood RNA tubes. A severity score was provided, ranging from 0 to 1 for increasing disease severity. The primary outcome was the accuracy of the IMX-SEV-3b in predicting ICU mortality, and we calculated the AUROC of the IMX-SEV-3b score, the biomarkers C-reactive protein (CRP), D-dimer, ferritin, leukocyte count, interleukin-6 (IL-6), lactate dehydrogenase (LDH), neutrophil-to-lymphocyte ratio (NLR), procalcitonin (PCT) and the SOFA score. A total of 53 patients were included between 1 March and 30 April 2020, with 47 of them being included within 72 h of their admission to the ICU. Of these, 18 (34%) patients died during their ICU stay, and the IMX-SEV-3b scores were significantly higher in non-survivors compared to survivors (0.65 versus 0.57, p = 0.05). The Area Under the Receiver Operating Characteristic Curve (AUROC) for prediction of ICU mortality by the IMX-SEV-3b was 0.65 (0.48–0.82). The AUROCs of the biomarkers ranged from 0.52 to 0.66, and the SOFA score had an AUROC of 0.81 (0.69–0.93). The AUROC of the pooled biomarkers CRP, D-dimer, ferritin, leukocyte count, IL-6, LDH, NLR and PCT for prediction of ICU mortality was 0.81 (IQR 0.69–0.93). Further validation in a larger interventional trial of a point-of-care version of the IMX-SEV-3b classifier is warranted to determine its value for patient management.</p

Intravenous fosfomycin-back to the future. Systematic review and meta-analysis of the clinical literature

Objectives: We conducted a systematic review and meta-analysis to summarize the clinical evidence and usage patterns of intravenous fosfomycin from its development to the present time. Methods: PubMed, the Cochrane Library and local journals were searched for relevant studies reporting aggregated data of intravenous fosfomycin use in adults and children, with no restrictions regarding study design. Single case reports were excluded. Data were systematically abstracted for all included studies. Clinical and microbiological efficacy from randomized controlled and comparative observational studies were synthesized using meta-analysis to calculate pooled effect sizes. Results: In all, 128 studies on intravenous fosfomycin in 5527 patients were evaluated. Fosfomycin was predominantly used for sepsis/bacteraemia, urinary tract, respiratory tract, bone and joint, and central nervous system infections. No difference in clinical (OR 1.44, 95% CI 0.96-2.15) or microbiological (OR 1.28, 95% CI 0.82-2.01) efficacy between fosfomycin and other antibiotics was observed in comparative trials. The pooled estimate for resistance development during fosfomycin monotherapy was 3.4% (95% CI 1.8%-5.1%). Fosfomycin showed a favourable safety profile, with generally mild adverse events not requiring discontinuation of treatment. Included studies explored intravenous fosfomycin as an antistaphylococcal agent in monotherapy and combination therapy, whereas studies from 1990 focused on combination therapy (fosfoymcin + beta-lactams or aminoglycosides) for challenging infections frequently caused by multidrug-resistant organisms. Conclusion: Intravenous fosfomycin can play a vital role in the antibiotic armamentarium, given its long history of effective and safe use. However, well-designed randomized controlled trials are still desired. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases