Diagnostic electrocardiographic patterns in Bantu myocardiopathy and constrictive pericarditis

The electrocardiogram was analysed in 28 adult Bantu patients with myocardiopathy and 33 with constrictive pericarditis. The over-all pattern was quite distinctive in the two groups. Patients with CP usually had sinus rhythm, notched P waves, low voltage QRS complexes in the standard and precordial leads, a normal QRS duration, no intraventricular conduction defects and a uniform and characteristic pattern of ST-T  wave change in most cases. In contrast, the ECG in MCO shows left ventricular hypertrophy, varying degrees of intraventricular conduction disturbance and patterns simulating myocardial infarction

Evaluation and application of the Baldwin-Lomax turbulence model in two-dimensional, unsteady, compressible boundary layers with and without separation in engine inlets

There is a practical need to model high speed flows that exist in jet engine inlets. The boundary layers that form in these inlets may be turbulent or laminar and either separated or attached. Also, unsteady supersonic inlets may be subject to frequent changes in operating conditions. Some changes in the operating conditions of the inlets may include varying the inlet geometry, bleeds and bypasses, and rotating or translating the centerbody. In addition, the inlet may be either started or unstarted. Therefore, a CFD code, used to model these inlets, may have to run for several different cases. Also, since the flow conditions through an unsteady inlet may be continually fluctuating, the CFD code which models these flows may have to be run over many time steps. Therefore, it would be beneficial that the code run quickly. Many turbulence models, however, are cumbersome to implement and require a lot of computer time to run, since they add to the number of differential equations to be solved to model a flow. The Baldwin-Lomax turbulence model is a popular model. It is an algebraic, eddy viscosity model. The Baldwin-Lomax model is used in many CFD codes because it is quick and easy to implement. In this paper, we will discuss implementing the Baldwin-Lomax turbulence model for both steady and unsteady compressible flows. In addition, these flows may be either separated or attached. In order to apply this turbulence model to flows which may be subjected to these conditions, certain modifications should be made to the original Baldwin-Lomax model. We will discuss these modifications and determine whether the Baldwin-Lomax model is a viable turbulence model that produces reasonably accurate results for high speed flows that can be found in engine inlets

BasinSim 1.0 A Windows-Based Watershed Modeling Package

BasinSim 1.0 for Windows is the product of a NOAA Coastal Zone Management grant (through the Virginia Coastal Resources Management Program) awarded to Drs. Ting Dai, R. L. Wetzel, I. C. Anderson, and L. W. Haas at the Virginia Institute of Marine Science, College of William and Mary in 1998. Additional support has been provided for the development and testing of this package and production of this user’s guide by grants from Virginia’s Chesapeake Bay Local Assistance Department (CBLAD). BasinSim 1.0 is a desktop simulation system that predicts sediment and nutrient loads for small to mid-sized watersheds. The simulation system is based on the Generalized Watershed Loading Functions (GWLF), a tested watershed model developed by Dr. Douglas Haith and his colleagues at Cornell University, New York (Haith and Shoemaker 1987, Haith et al. 1992). BasinSim 1.0 integrates an easy-to-use graphic Windows interface, extensive databases (land uses, population, soils, water discharge, water quality, climate, point nutrient sources, etc.), and the GWLF model (with modifications) into a single software package. It was designed to enable resource managers to visualize watershed characteristics, retrieve historic data (at the county and sub-watershed levels), manipulate land use patterns, and simulate nutrient (N, P, and organic C) and sediment loadings under various scenarios. The software will assist resource managers in making sound management decisions using the latest technology, information, and scientific knowledge. The system can also be used to educate local organizations and the general public about linkages between basinwide resource management and water quality

Determination of step--edge barriers to interlayer transport from surface morphology during the initial stages of homoepitaxial growth

We use analytic formulae obtained from a simple model of crystal growth by molecular--beam epitaxy to determine step--edge barriers to interlayer transport. The method is based on information about the surface morphology at the onset of nucleation on top of first--layer islands in the submonolayer coverage regime of homoepitaxial growth. The formulae are tested using kinetic Monte Carlo simulations of a solid--on--solid model and applied to estimate step--edge barriers from scanning--tunneling microscopy data on initial stages of Fe(001), Pt(111), and Ag(111) homoepitaxy.Comment: 4 pages, a Postscript file, uuencoded and compressed. Physical Review B, Rapid Communications, in press

Relaxation kinetics in two-dimensional structures

We have studied the approach to equilibrium of islands and pores in two dimensions. The two-regime scenario observed when islands evolve according to a set of particular rules, namely relaxation by steps at low temperature and smooth at high temperature, is generalized to a wide class of kinetic models and the two kinds of structures. Scaling laws for equilibration times are analytically derived and confirmed by kinetic Monte Carlo simulations.Comment: 6 pages, 7 figures, 1 tabl

Sharp Trace Hardy-Sobolev-Maz'ya Inequalities and the Fractional Laplacian

In this work we establish trace Hardy and trace Hardy-Sobolev-Maz'ya inequalities with best Hardy constants, for domains satisfying suitable geometric assumptions such as mean convexity or convexity. We then use them to produce fractional Hardy-Sobolev-Maz'ya inequalities with best Hardy constants for various fractional Laplacians. In the case where the domain is the half space our results cover the full range of the exponent $s \in (0,1)$ of the fractional Laplacians. We answer in particular an open problem raised by Frank and Seiringer \cite{FS}.Comment: 42 page

Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures

The application of extracellular vesicles (EVs) as natural delivery vehicles capable of enhancing tissue regeneration could represent an exciting new phase in medicine. We sought to define the capacity of EVs derived from mineralising osteoblasts (MO-EVs) to induce mineralisation in mesenchymal stem cell (MSC) cultures and delineate the underlying biochemical mechanisms involved. Strikingly, we show that the addition of MO-EVs to MSC cultures significantly (P < 0.05) enhanced the expression of alkaline phosphatase, as well as the rate and volume of mineralisation beyond the current gold-standard, BMP-2. Intriguingly, these effects were only observed in the presence of an exogenous phosphate source. EVs derived from non-mineralising osteoblasts (NMO-EVs) were not found to enhance mineralisation beyond the control. Comparative label-free LC-MS/MS profiling of EVs indicated that enhanced mineralisation could be attributed to the delivery of bridging collagens, primarily associated with osteoblast communication, and other non-collagenous proteins to the developing extracellular matrix. In particular, EV-associated annexin calcium channelling proteins, which form a nucleational core with the phospholipid-rich membrane and support the formation of a pre-apatitic mineral phase, which was identified using infrared spectroscopy. These findings support the role of EVs as early sites of mineral nucleation and demonstrate their value for promoting hard tissue regeneration