Model-based estimation of transmissibility and reinfection of SARS-CoV-2 P.1 variant

Acknowledgements We are grateful for the collaborative work of the reviewers and the entire group of the Observatório COVID-19 BR. In particular, we thank Verônica Coelho for critical inputs. We also thank the research funding agencies: the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil (Finance Code 001 to F.M.D.M., L.S.F. and T.P.P.), Conselho Nacional de Desenvolvimento Científico e Tecnológico—Brazil (grant number: 315854/2020-0 to M.E.B., 141698/2018-7 to R.L.P.S., 313055/2020-3 to P.I.P., 312559/2020-8 to M.A.S.M.V., 311832/2017-2 to R.A.K., 305703/2019-6 to A.A.M.S.) and Fundação de Amparo à Pesquisa do Estado de São Paulo—Brazil (grant number: 2019/26310-2 and 2017/26770-8 to C.F., 2018/26512-1 to O.C., 2018/24037-4 to S.P. and contract number: 2016/01343-7 to R.A.K.). The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the Centers of Disease Control and Prevention.Peer reviewe

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of l

Número mínimo de medições para a avaliação acurada de características agronômicas de pinhão-manso

Resumo: O objetivo deste trabalho foi identificar o método mais eficaz para estimar coeficientes de repetibilidade em progênies de meios-irmãos de pinhão-manso (Jatropha curcas) e predizer o número mínimo de medições necessárias para algumas características agronômicas da oleaginosa. Avaliaram-se 18 famílias de meios-irmãos, em delineamento de blocos ao acaso, com três repetições, de 2009 a 2013. Nesse período, as seguintes características foram avaliadas: altura de plantas, diâmetro do caule, número de ramos por planta, projeção da copa na linha, projeção da copa na entrelinha e produtividade de grãos. O coeficiente de repetibilidade (r) foi estimado a partir de diferentes estratégias: análise de variância; análise dos componentes principais (ACP), com base na matriz de correlações (CPCOR); ACP, com base na matriz de variâncias e covariâncias fenotípicas (CPCOV); e análise estrutural, com base na matriz de correlações. A estratégia CPCOV proporciona estimativas mais acuradas do coeficiente de repetibilidade e do número de medições necessárias (no mínimo quatro) para avaliação acurada (mínimo 80%) das características, devido ao comportamento cíclico das progênies

Application Of π Circuits For Simulation Of Corona Effect In Transmission Lines

In this article, it is represented by state variables phase a transmission line which parameters are considered frequency independently and frequency dependent. Based on previous analyses, it is used the reasonable number of π circuits and the number of blocks composed by parallel resistor and inductor for reduction of numerical oscillations. It is analyzed the influence of the increase of the RL parallel blocks in the obtained results. The RL parallel blocks are used for inclusion of the frequency influence in the transmission line longitudinal parameter. It is a simple model that is been used by undergraduate students for simulation of traveling wave phenomena in transmission lines. Considering the model without frequency influence, it is included a representation of the corona effect. Some simulations are carried considering the corona effect and they are compared to the results without this phenomenon. © 2012 IEEE.(1992) Transients Analysis Program Reference Manual, , Microtran Power System Analysis Corporation, Vancouver, CanadaDommel, H.W., (1996) EMTP Theory Book, , Department of Electrical Engineering, University of British Columbia, VancouverMamis, M.S., Computing of electromagnetic transients on transmissions lines with nonlinear components (2003) IEE Proceedings Generation, Transmission and Distribution, 150 (2), pp. 200-203Mamis, M.S., Nacaroglu, A., Transient voltage and current distributions on transmission lines (2003) IEE Proceedings Generation, Transmission and Distribution, 149 (6), pp. 705-712Yamanaka, F.N.R., Kurokawa, S., Prado, A.J., Pissolato, J., Bovolato, L.F., Analysis of longitudinal and temporal distribution of electromagnetic waves in transmission lines by using state-variable techniques (2005) Sixty Latin-American Congress: Electricity Generation and Transmission - VI CLAGTEE, , Mar Del PlataDommel, H.W., Digital computer solution of electromagnetic transients in single and multiphase networks (1969) IEEE Transactions on Power Apparatus and Systems, PAS-88, pp. 388-399. , AprilNelms, R.M., Steven, R., Newton, G.B., Sheble, L.L., Grigsby, Using a personal Computer to teach power system Transients (1989) IEEE Transactions on Power System, 4 (3). , AugustMacÍas, J.A.R., Expósito, A.G., Soler, A.B., A comparison of techniques for state space transient analysis of transmission lines (2005) IEEE Transactions on Power Delivery, 20 (2), pp. 894-903. , AprilBoyce, W.E., Diprima, R.C., (1994) Equações Diferenciais Elementares e Problemas de Valores de Contorno, , Rio de Janeiro: Guanabara KooganTavares, M.C., (1998) Modelo de Linha de Transmissão Polifásico Utilizando Quase-Modos, , Doctor Thesis, UNICAMP - The State University of Campinas, Campinas, BrazilMamis, M.S., State-space transient analysis of single-phase transmission lines with corona (2003) The International Conference on Power Systems Transients - IPST 2003, , 28th September - 2nd October, New Orleans, Louisiana, US