The Battle of the Schedulers: FreeBSD ULE vs. Linux CFS

This paper analyzes the impact on application performance of the design and implementation choices made in two widely used open-source schedulers: ULE, the default FreeBSD scheduler, and CFS, the default Linux scheduler. We compare ULE and CFS in otherwise identical circumstances. We have ported ULE to Linux, and use it to schedule all threads that are normally scheduled by CFS. We compare the performance of a large suite of applications on the modified kernel running ULE and on the standard Linux kernel running CFS. The observed performance differences are solely the result of scheduling decisions, and do not reflect differences in other subsystems between FreeBSD and Linux. There is no overall winner. On many workloads the two schedulers perform similarly, but for some workloads there are significant and even surprising differences. ULE may cause starvation, even when executing a single application with identical threads, but this starvation may actually lead to better application performance for some workloads. The more complex load balancing mechanism of CFS reacts more quickly to workload changes, but ULE achieves better load balance in the long run

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.

APO2L/TRAIL (TNF-related apoptosis-inducing ligand) induces death of tumor cells through two agonist receptors, TRAIL-R1 and TRAIL-R2. We demonstrate here that N-linked glycosylation (N-glyc) plays also an important regulatory role for TRAIL-R1-mediated and mouse TRAIL receptor (mTRAIL-R)-mediated apoptosis, but not for TRAIL-R2, which is devoid of N-glycans. Cells expressing N-glyc-defective mutants of TRAIL-R1 and mouse TRAIL-R were less sensitive to TRAIL than their wild-type counterparts. Defective apoptotic signaling by N-glyc-deficient TRAIL receptors was associated with lower TRAIL receptor aggregation and reduced DISC formation, but not with reduced TRAIL-binding affinity. Our results also indicate that TRAIL receptor N-glyc impacts immune evasion strategies. The cytomegalovirus (CMV) UL141 protein, which restricts cell-surface expression of human TRAIL death receptors, binds with significant higher affinity TRAIL-R1 lacking N-glyc, suggesting that this sugar modification may have evolved as a counterstrategy to prevent receptor inhibition by UL141. Altogether our findings demonstrate that N-glyc of TRAIL-R1 promotes TRAIL signaling and restricts virus-mediated inhibition

DYNAMIQUE D'EXPRESSION DU RECEPTEUR CD28 AU COURS DES PROCESSUS D'ACTIVATION DES LYMPHOCYTES T HUMAINS (UN CONTROLE DIFFERENT POUR LES LYMPHOCYTES T CD4+ ET LES LYMPHOCYTES T CD8+ (DES BIOL. MED.))

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

The Battle of the Schedulers: FreeBSD ULE vs. Linux CFS

This paper analyzes the impact on application performance of the design and implementation choices made in two widely used open-source schedulers: ULE, the default FreeBSD scheduler, and CFS, the default Linux scheduler. We compare ULE and CFS in otherwise identical circumstances. We have ported ULE to Linux, and use it to schedule all threads that are normally scheduled by CFS. We compare the performance of a large suite of applications on the modified kernel running ULE and on the standard Linux kernel running CFS. The observed performance differences are solely the result of scheduling decisions, and do not reflect differences in other subsystems between FreeBSD and Linux.There is no overall winner. On many workloads the two schedulers perform similarly, but for some workloads there are significant and even surprising differences. ULE may cause starvation, even when executing a single application with identical threads, but this starvation may actually lead to better application performance for some workloads. The more complex load balancing mechanism of CFS reacts more quickly to workload changes, but ULE achieves better load balance in the long run