6,463 research outputs found
Voluntary wheel running reverses the decrease in subventricular zone neurogenesis caused by corticosterone
Adult neurogenesis within the dentate gyrus of the hippocampus can be increased by voluntary exercise but is suppressed under stress, such as with corticosterone (CORT). However, the effects of exercise and corticosterone on the cell proliferation of the other traditional neurogenic site, the subventricular zone (SVZ) have been reported with controversial results. In addition, the co-treatment effects of voluntary exercise and corticosterone have not been investigated. This study aims to determine whether corticosterone can suppress cell proliferation in the SVZ, and whether this can be reversed by voluntary exercise. In the present study, the effect of chronic (4 weeks) corticosterone treatment and wheel running simultaneously on the SVZ cell proliferation of adult Sprague-Dawley rats was examined. The results showed that cell proliferation indicated by bromodeoxyuridine (BrdU) was increased by voluntary wheel running whereas it was decreased by corticosterone treatment within the SVZ of the rats without running. For the rats with both corticosterone treatment and wheel running, it was found that the number of BrdU-labeled cells was approximately at the same level as the vehicle control group. Furthermore, these proliferating cells expressed doublecortin (DCX), a migrating neuroblast marker. Wheel running increased the percentage of BrdU-labeled cells expressing DCX in the SVZ whereas corticosterone treatment decreased this percentage. Thus, chronic injection of corticosterone can decrease the number of proliferating cells while wheel running can reverse the decrease in cell proliferation within the SVZ to normal levels. In addition, corticosterone can suppress the cell differentiation within the SVZ and this was alleviated by wheel running as indicated by the double-labeling of BrdU and DCX.published_or_final_versio
Load-Balancing for Parallel Delaunay Triangulations
Computing the Delaunay triangulation (DT) of a given point set in
is one of the fundamental operations in computational geometry.
Recently, Funke and Sanders (2017) presented a divide-and-conquer DT algorithm
that merges two partial triangulations by re-triangulating a small subset of
their vertices - the border vertices - and combining the three triangulations
efficiently via parallel hash table lookups. The input point division should
therefore yield roughly equal-sized partitions for good load-balancing and also
result in a small number of border vertices for fast merging. In this paper, we
present a novel divide-step based on partitioning the triangulation of a small
sample of the input points. In experiments on synthetic and real-world data
sets, we achieve nearly perfectly balanced partitions and small border
triangulations. This almost cuts running time in half compared to
non-data-sensitive division schemes on inputs exhibiting an exploitable
underlying structure.Comment: Short version submitted to EuroPar 201
Comment on Higgs Inflation and Naturalness
We rebut the recent claim (arXiv:0912.5463) that Einstein-frame scattering in
the Higgs inflation model is unitary above the cut-off energy Lambda ~ Mp/xi.
We show explicitly how unitarity problems arise in both the Einstein and Jordan
frames of the theory. In a covariant gauge they arise from non-minimal Higgs
self-couplings, which cannot be removed by field redefinitions because the
target space is not flat. In unitary gauge, where there is only a single scalar
which can be redefined to achieve canonical kinetic terms, the unitarity
problems arise through non-minimal Higgs-gauge couplings.Comment: 5 pages, 1 figure V3: Journal Versio
Globular Cluster Distance Determinations
The present status of the distance scale to Galactic globular clusters is
reviewed. Six distance determination techniques which are deemed to be most
reliable are discussed in depth. These different techniques are used to
calibrate the absolute magnitude of the RR Lyrae stars. The various
calibrations fall into three groups. Main sequence fitting using Hipparcos
parallaxes, theoretical HB models and the RR Lyrae in the LMC all favor a
bright calibration, implying a `long' globular cluster distance scale. White
dwarf fitting and the astrometric distances yield a somewhat fainter RR Lyrae
calibration, while the statistical parallax solution yields faint RR Lyrae
stars implying a `short' distance scale to globular clusters. Various secondary
distance indicators discussed all favor the long distance scale. The `long' and
`short' distance scales differ by (0.31+/-0.16) mag. Averaging together all of
the different distance determinations yields Mv(RR) = (0.23+/-0.04)([Fe/H] +
1.6) + (0.56+/-0.12) mag.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in pres
Distances and ages of globular clusters using Hipparcos parallaxes of local subdwarfs
We discuss the impact of Population II and Globular Cluster (GCs) stars on
the derivation of the age of the Universe, and on the study of the formation
and early evolution of galaxies, our own in particular. The long-standing
problem of the actual distance scale to Population II stars and GCs is
addressed, and a variety of different methods commonly used to derive distances
to Population II stars are briefly reviewed. Emphasis is given to the
discussion of distances and ages for GCs derived using Hipparcos parallaxes of
local subdwarfs. Results obtained by different authors are slightly different,
depending on different assumptions about metallicity scale, reddenings, and
corrections for undetected binaries. These and other uncertainties present in
the method are discussed. Finally, we outline progress expected in the near
future.Comment: Invited review article to appear in: `Post-Hipparcos Cosmic Candles',
A. Heck & F. Caputo (Eds), Kluwer Academic Publ., Dordrecht, in press. 22
pages including 3 tables and 2 postscript figures, uses Kluwer's crckapb.sty
LaTeX style file, enclose
Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy
Efforts to curb the tuberculosis (TB) pandemic remain hindered by a lack of objective measures to quantify disease severity and track treatment success that are valid in both HIV-1-infected and -uninfected TB patients. Ralph et al. [1] developed a promising radiographic scoring system, with baseline scores being predictive of sputum smear conversion at 2 months, but it is reliant on skilled readers and has not been systematically validated in predominantly HIV-infected study populations with varying CD4 counts. Superior to conventional chest radiography, high-resolution computed tomography (HRCT) is a highly sensitive tool to track endobronchial TB disease extent [2]
Random Matrix Theory and Chiral Symmetry in QCD
Random matrix theory is a powerful way to describe universal correlations of
eigenvalues of complex systems. It also may serve as a schematic model for
disorder in quantum systems. In this review, we discuss both types of
applications of chiral random matrix theory to the QCD partition function. We
show that constraints imposed by chiral symmetry and its spontaneous breaking
determine the structure of low-energy effective partition functions for the
Dirac spectrum. We thus derive exact results for the low-lying eigenvalues of
the QCD Dirac operator. We argue that the statistical properties of these
eigenvalues are universal and can be described by a random matrix theory with
the global symmetries of the QCD partition function. The total number of such
eigenvalues increases with the square root of the Euclidean four-volume. The
spectral density for larger eigenvalues (but still well below a typical
hadronic mass scale) also follows from the same low-energy effective partition
function. The validity of the random matrix approach has been confirmed by many
lattice QCD simulations in a wide parameter range. Stimulated by the success of
the chiral random matrix theory in the description of universal properties of
the Dirac eigenvalues, the random matrix model is extended to nonzero
temperature and chemical potential. In this way we obtain qualitative results
for the QCD phase diagram and the spectrum of the QCD Dirac operator. We
discuss the nature of the quenched approximation and analyze quenched Dirac
spectra at nonzero baryon density in terms of an effective partition function.
Relations with other fields are also discussed.Comment: invited review article for Ann. Rev. Nucl. Part. Sci., 61 pages, 11
figures, uses ar.sty (included); references added and typos correcte
Association analysis of polymorphism in KIAA1717, HUMMLC2B, DECR1 and FTO genes with meat quality traits of the Berkshire breed
Single nucleotide polymorphisms (SNPs) in KIAA1717, HUMMLC2B, DECR1, and FTO genes have been found to be associated with some pork meat quality traits. In this study, we discovered that, in addition to meat quality traits reported previously, SNPs in these genes also are significantly associated with other meat quality traits in the Berkshire breed. A total of 323 Berkshire pigs bred under the same conditions were used for meat quality evaluation and polymerase chain reaction-amplified genes with restriction endonucleases (PCR-RFLP) genotyping analyses. The association analysis of RFLP genotyping with meat quality traits revealed that the SNPs in these 4 genes have novel associations with multiple meat quality traits (p < 0.01 or p < 0.05); a SNP in KIAA1717 was associated with meat color (CIE L), backfat thickness, drip loss, water-holding capacity, and pH24hr; a SNP in HUMMLC2B was associated with chemical composition (collagen), drip loss, shear force, and pH24hr; a SNP in DECR1 was associated with meat color (CIE a and b) and backfat thickness; and a SNP in FTO was associated with meat color (CIE L, a and b), protein content, drip loss, and water-holding capacity. Taken collectively, our results suggest that these 4 SNPs may be used for marker-assisted selection as a genetic marker for meat quality traits in Berkshire pigs.Key words: Berkshire, genetic markers, meat quality, SN
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