The suburban landscape: 200 years of gardens and gardening.

Gardens are a vital part of what defines the suburban landscape. Gardened spaces between the houses, roads and stations help define the suburb as ‘suburban’ – at the heart of which is the private garden, at both the front and back of the dwelling. This exhibition considered the significance of gardens and gardening in the making of what has become the most ‘English’ of landscape environments. The first part looked at the evolution of the landscape as a whole, including the development of public open spaces. It suggested that despite subsequent infilling and densification, the landscape had largely acquired its character by the Second World War. Although increasingly at risk of development, private gardens still make up a large part of the suburban landscape and gardening remains one of the nation’s consuming passions. The second part of the exhibition argued that the private uses of the suburban garden are intimately linked to the shared values of the larger public landscape

Influence of different eCG doses on the rabbit doe ovary response, fertilizing aptitude and embryo development

[EN] The aim of this experiment was to compare the ovary response, the fertilising aptitude and the embryo development of multiparous rabbit does having received during the whole career 0 (control: no injection, group 0), 8 or 25 IU of eCG (groups 8 and 25, respectively) 48 h before each 4 d post partum insemination. After the 11th series of insemination, two groups of 60 does were sacrifi ced 30 h or 14 d after insemination. The percentage of ovulating females does not vary according to the eCG treatment, but the ovulation rate (number of corpora lutea per ovulating does) and the fertilising rate (number of segmented ova/number of corpora lutea x100) increases with eCG dose [10.2, 11.1, 12.3 corpora lutea (P=0.011); 61.6 vs 97.5, 81.2% (P<0.001), for groups 0, 8 and 25 IU respectively]. In a same way, at 14 d of pregnancy, the embryo survival (1-(number of corpora lutea ¿ number of alive embryos/ number of corpora lutea)) increases with the injected amount of eCG (55.1 vs 69.9 and 83.1% for groups 0, 8 and 25, respectively, P=0.023). Moreover, eCG completely removes the fertilising failure independent of ovulation. Compared with the other does, lactating-non-receptive does have a lower fertilisation rate (70.0 vs 90.2%, P=0.008) and a weaker embryo survival (55.3 vs 83.5%, P<0.001). It is concluded that with intensive reproduction rhythm (4 d post partum insemination), an 8 IU of eCG injected 48 h before insemination is enough to enhance the ovulation rate, the embryo survival and the fertilisation rate of multiparous does.Ttheau-Clément, M.; Lebas, F.; Falières, J. (2010). Influence of different eCG doses on the rabbit doe ovary response, fertilizing aptitude and embryo development. World Rabbit Science. 16(2). doi:10.4995/wrs.2008.62916

Influence of different eCG doses on sexual receptivity and productivity of rabbit does

[EN] The aim of this study was to examine sexual receptivity and productivity of does injected 48 h before insemination with 8 or 25 IU of eCG (groups 8 and 25, respectively) in comparison with a control group (no injection, group 0). One hundred twenty four does were inseminated during 11 consecutive cycles (reproduction rythm: 35 d; inseminations: 4 d post partum and weaning: 28 d post partum). In comparison with the control group, eCG signifi cantly improves the receptivity of does (60.3 vs 80.5 and 79.8%; P<0.001), kindling rate (70.4 vs 80.9 and 79.4%; P=0.030) and the number of weaned rabbits/insemination (5.9 vs 7.1 and 7.1; P=0.008) for group 0, 8 and 25 respectively, during the whole experiment. eCG effi ciency is not obviously demonstrated for primiparous and non-lactating does. Authors conclude that only an 8 IU dose is able to improve 62% the productivity (measured as weaned rabbits per insemination) of multiparous and lactating does inseminated 4 d post partum.Theau-Clément, M.; Lebas, F.; Boiti, C.; G. Brecchia, G.; Mercier, P. (2010). Influence of different eCG doses on sexual receptivity and productivity of rabbit does. World Rabbit Science. 16(2). doi:10.4995/wrs.2008.62816

The effects of the complete replacement of barley and soybean meal with hard wheat by-products on diet digestibility, growth and slaughter traits of a local Algerian rabbit population

[EN] Eighty one rabbits were used to study the utilisation of hard wheat by-products on the growth of rabbits from a local Algerian population. At weaning (28 d, 501±99 g), the animals were individually caged and received ad libitum one of the three experimental diets for 49 d. The control diet included 26% wheat bran (W26: control diet), alfalfa, bar- ley and soybean meal. The two other diets were formulated by substituting barley and soybean meal with hard wheat by-products, and contained 60% (W60) or 67% (W67) of these by-products (50 or 57% bran and 10% middling). On average, diets contained 11.8% crude fibre and crude protein decreased from 18.3 (W26) to 16.1% (W67). Growth traits and slaughter performances were recorded. Another group of thirty animals was used to determine dietary nutrient di- gestibility from 42 to 46 d of age. Dry matter digestibility and digestible energy content were lower in the W60 and W67 diets than in the control diet (W26) (71.3 and 71.5% vs. 74.9%, and 11.9 and 11.9 vs. 12.5 MJ/kg, respectively; P<0.01). In contrast, crude fibre digestibility was lower in W26 (21.9%) than in the other two diets (29.6 and 32.2% for W60 and W67, respectively; P<0.01). The growth rates were similar for all three groups (28.0, 27.1 and 26.0 g/d for W26, W60 and W67) as were the feed conversion ratios (3.14, 3.17 and 3.10, respectively). Dressing out percentage (66.4±2.0% on average for the cold carcass) was not affected by the amount of wheat by-products in the diet. The total mortality rate was high (23%), probably corresponding to the low crude fibre content of the three experimental diets, but was not connected to the amount of wheat by-products.Lakabi-Ioualitene, D.; Lounaouci-Ouyed, G.; Berchiche, M.; Lebas, F.; Fortun-Lamothe, L. (2010). The effects of the complete replacement of barley and soybean meal with hard wheat by-products on diet digestibility, growth and slaughter traits of a local Algerian rabbit population. World Rabbit Science. 16(2). doi:10.4995/wrs.2008.63216

Positive allometry and the prehistory of sexual selection

The function of the exaggerated structures that adorn many fossil vertebrates remains largely unresolved. One recurrent hypothesis is that these elaborated traits had a role in thermoregulation. This orthodoxy persists despite the observation that traits exaggerated to the point of impracticality in extant organisms are almost invariably sexually selected. We use allometric scaling to investigate the role of sexual selection and thermoregulation in the evolution of exaggerated traits of the crested pterosaur Pteranodon longiceps and the sail-backed eupelycosaurs Dimetrodon and Edaphosaurus. The extraordinarily steep positive allometry of the head crest of Pteranodon rules out all of the current hypotheses for this trait's main function other than sexual signaling. We also find interspecific patterns of allometry and sexual dimorphism in the sails of Dimetrodon and patterns of elaboration in Edaphosaurus consistent with a sexually selected function. Furthermore, small ancestral, sailbacked pelycosaurs would have been too small to need adaptations to thermoregulation. Our results question the popular view that the elaborated structures of these fossil species evolved as thermoregulatory organs and provide evidence in support of the hypothesis that Pteranodon crests and eupelycosaur sails are among the earliest and most extreme examples of elaborate sexual signals in the evolution of terrestrial vertebrates. © 2010 by The University of Chicago

The mortality associated with erythema nodosum leprosum in Ethiopia: a retrospective hospital-based study.

BACKGROUND: Erythema nodosum leprosum (ENL) is a debilitating multisystem disorder which complicates leprosy. It is characterised by fever, malaise and painful erythematous cutaneous nodules. ENL is often recurrent or chronic in nature and frequently severe. Patients often require prolonged treatment with high doses of oral corticosteroids. There are no data on the mortality associated with treated ENL. METHODOLOGY: The notes of patients who were admitted, discharged, transferred to another facility or died with a diagnosis of leprosy or a leprosy-related complication for a five year period were reviewed. RESULT/DISCUSSION: 414 individuals were identified from the ward database. 312 (75.4%) patient records were located and reviewed. Ninety-nine individuals had ENL and 145 had a Type 1 reaction. The median age of individuals with ENLwas 25 years. Eight patients with erythema nodosum leprosum died compared with two diagnosed with Type 1 reaction. This difference is statistically significant (p = 0.0168, Fisher's Exact Test). There is a significant mortality and morbidity associated with ENL in this Ethiopian cohort. The adverse outcomes seen are largely attributable to the chronic administration of oral corticosteroids used to control the inflammatory and debilitating symptoms of the condition

A double-masked placebo-controlled trial of azithromycin to prevent child mortality in Burkina Faso, West Africa: Community Health with Azithromycin Trial (CHAT) study protocol.

BACKGROUND:Biannual, mass azithromycin distribution has previously been shown to reduce all-cause child mortality in sub-Saharan Africa. Subgroup analysis suggested that the strongest effects were in the youngest children, leading to the hypothesis that targeting younger age groups might be an effective strategy to prevent mortality. We present the methods of two randomized controlled trials designed to evaluate mass and targeted azithromycin distribution for the prevention of child mortality in Burkina Faso, West Africa. METHODS/DESIGN:The Child Health with Azithromycin Treatment (CHAT) study consists of two nested, randomized controlled trials. In the first, communities are randomized in a 1:1 fashion to biannual, mass azithromycin distribution or placebo. The primary outcome is under-5 all-cause mortality measured at the community level. In the second, children attending primary healthcare facilities during the first 5-12 weeks of life for a healthy child visit (e.g., for vaccination) are randomized in a 1:1 fashion to a single orally administered dose of azithromycin or placebo. The primary outcome is all-cause mortality measured at 6 months of age. The trial commenced enrollment in August 2019. DISCUSSION:This study is expected to provide evidence on two health systems delivery approaches (mass and targeted treatment) for azithromycin to prevent all-cause child mortality. The results will inform global and national policies related to azithromycin for the prevention of child mortality. TRIAL REGISTRATION:ClinicalTrials.gov, ID: NCT03676764. Registered on 19 September 2018; prospectively registered pre results

Neonatal azithromycin administration to prevent infant mortality: study protocol for a randomised controlled trial.

IntroductionBiannual mass azithromycin distribution to children aged 1-59 months has been shown to reduce all-cause mortality. Children under 28 days of age were not treated in studies evaluating mass azithromycin distribution for child mortality due to concerns related to infantile hypertrophic pyloric stenosis (IHPS). Here, we report the design of a randomised controlled trial to evaluate the efficacy and safety of administration of a single dose of oral azithromycin during the neonatal period.Methods and analysisThe Nouveaux-nés et Azithromycine: une Innovation dans le Traitement des Enfants (NAITRE) study is a double-masked randomised placebo-controlled trial designed to evaluate the efficacy of a single dose of azithromycin (20 mg/kg) for the prevention of child mortality. Newborns (n=21 712) aged 8-27 days weighing at least 2500 g are 1:1 randomised to a single, directly observed, oral dose of azithromycin or matching placebo. Participants are followed weekly for 3 weeks after treatment to screen for adverse events, including IHPS. The primary outcome is all-cause mortality at the 6-month study visit.Ethics and disseminationThis study was approved by the Institutional Review Boards at the University of California, San Francisco in San Francisco, USA (Protocol #18-25027) and the Comité National d'Ethique pour la Recherche in Ouagadougou, Burkina Faso (Protocol #2018-10-123). The findings of this trial will be presented at local, regional and international meetings and published in open access peer-reviewed journals.Trial registration numberNCT03682653; Pre-results