Spatio-temporal variability of warm rain events over southern West Africa from geostationary satellite observations for climate monitoring and model evaluation

This paper presents the spatiotemporal variability of warm rain events over southern West Africa (SWA) during the summer monsoon season for the first time, using Spinning Enhanced Visible Infrared Radiometer (SEVIRI) observations on the Meteosat geostationary satellites. The delineation of warm rain events is based on the principle that precipitating low-level clouds are associated with either sufficient water content or large cloud droplet size. Capitalising on the ability of spaceborne radar to resolve vertical cloud structures and detect the presence of precipitation, the delineation is trained by collocated SEVIRI and CloudSat observations. The resulting 12-years of observations from SEVIRI are used to examine the spatial, diurnal, seasonal and interannual variability of warm rain events over SWA. Warm rain events predominate during the monsoon in August, with little interannual variability, and persist over orography in the morning and the coasts after midday, likely enhanced by orographic lifting and land-sea breeze effects. Warm clouds have a much higher probability of precipitation along the coastlines of Liberia and Nigeria compared to the central SWA coastline and further inland. Finally, when evaluating an 8-day yet high-spatial resolution model simulation, we find that warm rain frequencies from the simulation agree well with SEVIRI near the coast but simulated warm cloud cover and thus warm rain frequencies are too low over the Gulf of Guinea. The probability of precipitation of warm clouds is also too low inland. The newly developed climatology creates opportunities to further investigate the diurnal cycle of warm rain, study aerosol-cloud-precipitation interactions, and assess the role of warm rain in the water cycle across Africa and beyond

CD152 (CTLA-4) Determines CD4 T Cell Migration In Vitro and In Vivo

BACKGROUND:Migration of antigen-experienced T cells to secondary lymphoid organs and the site of antigenic-challenge is a mandatory prerequisite for the precise functioning of adaptive immune responses. The surface molecule CD152 (CTLA-4) is mostly considered as a negative regulator of T cell activation during immune responses. It is currently unknown whether CD152 can also influence chemokine-driven T cell migration. METHODOLOGY/PRINCIPAL FINDINGS:We analyzed the consequences of CD152 signaling on Th cell migration using chemotaxis assays in vitro and radioactive cell tracking in vivo. We show here that the genetic and serological inactivation of CD152 in Th1 cells reduced migration towards CCL4, CXCL12 and CCL19, but not CXCL9, in a G-protein dependent manner. In addition, retroviral transduction of CD152 cDNA into CD152 negative cells restored Th1 cell migration. Crosslinking of CD152 together with CD3 and CD28 stimulation on activated Th1 cells increased expression of the chemokine receptors CCR5 and CCR7, which in turn enhanced cell migration. Using sensitive liposome technology, we show that mature dendritic cells but not activated B cells were potent at inducing surface CD152 expression and the CD152-mediated migration-enhancing signals. Importantly, migration of CD152 positive Th1 lymphocytes in in vivo experiments increased more than 200% as compared to CD152 negative counterparts showing that indeed CD152 orchestrates specific migration of selected Th1 cells to sites of inflammation and antigenic challenge in vivo. CONCLUSIONS/SIGNIFICANCE:We show here, that CD152 signaling does not just silence cells, but selects individual ones for migration. This novel activity of CD152 adds to the already significant role of CD152 in controlling peripheral immune responses by allowing T cells to localize correctly during infection. It also suggests that interference with CD152 signaling provides a tool for altering the cellular composition at sites of inflammation and antigenic challenge

sj-docx-1-psp-10.1177_01461672221122515 – Supplemental material for Feeling Appreciated Predicts Prosocial Motivation in Avoidantly Attached Individuals

Supplemental material, sj-docx-1-psp-10.1177_01461672221122515 for Feeling Appreciated Predicts Prosocial Motivation in Avoidantly Attached Individuals by Kristina M. Schrage, Bonnie M. Le, Jennifer E. Stellar and Emily A. Impett in Personality and Social Psychology Bulletin</p

Neuron-Specific Enolase Levels in Adults Under Venoarterial Extracorporeal Membrane Oxygenation

International audienceObjectives: We aimed to determine if elevations in serum neuron-specific enolase are associated with brain injury and outcomes in adults who require venoarterial extracorporeal membrane oxygenation. Design: Prospective observational study. Setting: Two ICUs of a university hospital, Paris, France. Patients: Consecutive adult patients treated with venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock or in-hospital refractory cardiac arrest. Interventions: None. Measurements and Main Results: Serum sampled 1, 3, and 7 days after venoarterial extracorporeal membrane oxygenation cannulation was stored at –80°C and neuron-specific enolase concentrations were measured in batches at the end of the study. The association between neuron-specific enolase concentrations and outcomes (28-d mortality and poor outcome, defined by a score of 4–6 on the modified Rankin scale at 90 d) were explored by multivariable logistic regression, with neuron-specific enolase concentrations dichotomized according to median values. One-hundred three patients were included, of whom 26 (25%) received preextracorporeal membrane oxygenation cardiopulmonary resuscitation. Median (interquartile range) day-1, day-3, and day-7 neuron-specific enolase serum concentrations were 37 μg/L (26–51 μg/L), 25 μg/L (19–37) μg/L, and 22 μg/L (17–31 μg/L). After adjustment for Simplified Acute Physiology Score II, preextracorporeal membrane oxygenation cardiopulmonary resuscitation, and Sepsis Organ Failure Assessment score at time of cannulation, a day-3 neuron-specific enolase greater than 25 μg/L remained independently associated with 28-day mortality (adjusted odds ratio, 4.98; 95% CI, 1.86–13.32) and poor outcome at 90 days (adjusted odds ratio, 4.63; 95% CI, 1.81–11.84). A day-3 neuron-specific enolase threshold greater than 80 μg/L had a 100% specificity for prediction of both mortality (95% CI, 92–100%) and poor functional outcome (95% CI, 89–100%). In a subset of patients who underwent brain CT, neuron-specific enolase concentrations were significantly higher in patients diagnosed with stroke, as compared with those without stroke. Conclusions: In adult patients under venoarterial extracorporeal membrane oxygenation, day-3 serum neuron-specific enolase concentrations are independently associated with short-term mortality and poor functional outcomes. These findings deserve validation in a multicenter setting