21,424 research outputs found
Estimating Diffusion Network Structures: Recovery Conditions, Sample Complexity & Soft-thresholding Algorithm
Information spreads across social and technological networks, but often the
network structures are hidden from us and we only observe the traces left by
the diffusion processes, called cascades. Can we recover the hidden network
structures from these observed cascades? What kind of cascades and how many
cascades do we need? Are there some network structures which are more difficult
than others to recover? Can we design efficient inference algorithms with
provable guarantees?
Despite the increasing availability of cascade data and methods for inferring
networks from these data, a thorough theoretical understanding of the above
questions remains largely unexplored in the literature. In this paper, we
investigate the network structure inference problem for a general family of
continuous-time diffusion models using an -regularized likelihood
maximization framework. We show that, as long as the cascade sampling process
satisfies a natural incoherence condition, our framework can recover the
correct network structure with high probability if we observe
cascades, where is the maximum number of parents of a node and is the
total number of nodes. Moreover, we develop a simple and efficient
soft-thresholding inference algorithm, which we use to illustrate the
consequences of our theoretical results, and show that our framework
outperforms other alternatives in practice.Comment: To appear in the 31st International Conference on Machine Learning
(ICML), 201
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Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells.
We studied the cell-surface delivery pathways of newly synthesized membrane glycoproteins in MDCK cells and for this purpose we characterized an endogenous apical integral membrane glycoprotein. By combining a pulse-chase protocol with domain-selective cell-surface biotinylation, immune precipitation, and streptavidin-agarose precipitation (Le Bivic et al. 1989. Proc. Natl. Acad. Sci USA. 86:9313-9317), we followed the appearance at the cell surface of a major apical sialoglycoprotein, gp114, a basolateral protein, uvomorulin, and a transcytosing protein, the polyimmunoglobulin receptor (pIg-R). We determined that both gp114 and uvomorulin appeared to be delivered directly to their respective surface, with mistargeting levels of 8 and 2%, respectively. Using the same technique, the pIg-R was first detected on the basolateral domain and then on the apical domain, to be finally released into the apical medium, as described (Mostov, K. E., and D. L. Deitcher. 1986. Cell. 46:613-621). To directly determine whether the gp114 pool present on the basolateral surface was a precursor of the apical gp114, we compared it with the equivalent pIg-R pool, by labeling with sulfo-NHS-SS-biotin, a cleavable, tight junction-impermeable probe, and by following the fraction of this probe that became resistant to basal glutathione and accessible to apical glutathione during incubation at 37 degrees C. We found that, contrary to pIg-R, basolateral gp114 was poorly endocytosed and was not transcytosed to the apical side. These results demonstrate that an endogenous apical integral membrane glycoprotein of Madin-Darby canine kidney cells is sorted intracellularly and is vectorially targeted to the apical surface
The TRIZ-CBR synergy: A knowledge based innovation process
Today innovation is recognised as the main driving force in the market. This complex process involves several intangible dimensions, such as creativity, knowledge and social interactions among others. Creativity is the starting point of the process, and knowledge is the force that transforms and materialises creativity in new products, services and processes. In this paper a synergy that aims to assists the innovation process is presented. The synergy combines several concepts and tools of the theory of inventive problem solving (TRIZ) and the case-based reasoning (CBR) process. The main objective of this synergy is to support creative engineering design and problem solving. This synergy is based on the strong link between knowledge and action. In this link, TRIZ offers several concepts and tools to facilitate concept creation and to solve problems, and the CBR process offers a framework capable of storing and reusing knowledge with the aim of accelerating the innovation process
Shaping Social Activity by Incentivizing Users
Events in an online social network can be categorized roughly into endogenous
events, where users just respond to the actions of their neighbors within the
network, or exogenous events, where users take actions due to drives external
to the network. How much external drive should be provided to each user, such
that the network activity can be steered towards a target state? In this paper,
we model social events using multivariate Hawkes processes, which can capture
both endogenous and exogenous event intensities, and derive a time dependent
linear relation between the intensity of exogenous events and the overall
network activity. Exploiting this connection, we develop a convex optimization
framework for determining the required level of external drive in order for the
network to reach a desired activity level. We experimented with event data
gathered from Twitter, and show that our method can steer the activity of the
network more accurately than alternatives
JSBML: a flexible Java library for working with SBML
The specifications of the Systems Biology Markup Language (SBML) define standards for storing and exchanging computer models of biological processes in text files. In order to perform model simulations, graphical visualizations and other software manipulations, an in-memory representation of SBML is required. We developed JSBML for this purpose. In contrast to prior implementations of SBML APIs, JSBML has been designed from the ground up for the Javaâą programming language, and can therefore be used on all platforms supported by a Java Runtime Environment. This offers important benefits for Java users, including the ability to distribute software as Java Web Start applications. JSBML supports all SBML Levels and Versions through Level 3 Version 1, and we have strived to maintain the highest possible degree of compatibility with the popular library libSBML. JSBML also supports modules that can facilitate the development of plugins for end user applications, as well as ease migration from a libSBML-based backend
Determining position, velocity and acceleration of free-ranging animals with a low-cost unmanned aerial system
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