Alcohol and HIV Disease Progression: Weighing the Evidence

Heavy alcohol use is commonplace among HIV-infected individuals; however, the extent that alcohol use adversely impacts HIV disease progression has not been fully elucidated. Fairly strong evidence suggests that heavy alcohol consumption results in behavioral and biological processes that likely increase HIV disease progression, and experimental evidence of the biological effect of heavy alcohol on simian immunodeficiency virus in macaques is quite suggestive. However, several observational studies of the effect of heavy alcohol consumption on HIV progression conducted in the 1990s found no association of heavy alcohol consumption with time to AIDS diagnosis, while some more recent studies showed associations of heavy alcohol consumption with declines of CD4 cell counts and nonsuppression of HIV viral load. We discuss several plausible biological and behavioral mechanisms by which alcohol may cause HIV disease progression, evidence from prospective observational human studies, and suggest future research to further illuminate this important issue

No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations:

Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken a candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether polymorphisms in IL10, IL8, IL4, HLAG, TNFA, TNX4LB, IL6, IFNG, MIF, APOL1, HLAA, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH have a role in HAT

Note sur l'évolution des rapports entre la terre et les hommes dans la vallée inférieure du Guadalquivir

Drain Mothré Michel, Le Roux Patrick. Note sur l'évolution des rapports entre la terre et les hommes dans la vallée inférieure du Guadalquivir . In: Mélanges de la Casa de Velázquez, tome 8, 1972. pp. 595-603

Influence of embryonic urogenital sinus mesenchyme on the cytodifferentiation of the dunning prostatic adenocarcinoma

Optical ultrasonic sensors have been commonly used in research laboratories long before Monchalin’s classic review paper entitled “Optical Detection of Ultrasound” [1] in 1986 and yet, optical ultrasonic sensors have not made a successful transition from the laboratory to industry. This sensing technology has had plenty of time to mature. In fact, the components which comprise the optical sensors have been significantly enhanced during this time period. Despite the large gains in gas laser, solid state laser, diode laser, photodiode, fiber optic, non-linear optic, electronic design, data acquisition, and general sensing technology since 1986, optical ultrasonic sensors have not made it out of the laboratory and into industry