2,360 research outputs found
Chelator-facilitated removal of iron from transferrin: Relevance to combined chelation therapy
Current iron chelation therapy consists primarily of DFO (desferrioxamine),
which has to be administered via intravenous infusion,
together with deferiprone and deferasirox, which are orally-active
chelators. These chelators, although effective at decreasing the
iron load, are associated with a number of side effects. Grady
suggested that the combined administration of a smaller bidentate
chelator and a larger hexadentate chelator, such as DFO, would
result in greater iron removal than either chelator alone [Grady,
Bardoukas and Giardina (1998) Blood 92, 16b]. This in turn
could lead to a decrease in the chelator dose required. To test
this hypothesis, the rate of iron transfer from a range of bidentate
HPO (hydroxypyridin-4-one) chelators to DFO was monitored.
Spectroscopic methods were utilized to monitor the decrease in
the concentration of the Fe–HPO complex. Having established
that the shuttling of iron from the bidentate chelator to DFO
does occur under clinically relevant concentrations of chelator,
studies were undertaken to evaluate whether this mechanism of
transfer would apply to iron removal from transferrin. Again, the
simultaneous presence of both a bidentate chelator and DFO was
found to enhance the rate of iron chelation from transferrin at
clinically relevant chelator levels. Deferiprone was found to be
particularly effective at ‘shuttling’ iron from transferrin to DFO,
probably as a result of its small size and relative low affinity for
iron compared with other analogous HPO chelators
Shocks and Universal Statistics in (1+1)-Dimensional Relativistic Turbulence
We propose that statistical averages in relativistic turbulence exhibit
universal properties. We consider analytically the velocity and temperature
differences structure functions in the (1+1)-dimensional relativistic
turbulence in which shock waves provide the main contribution to the structure
functions in the inertial range. We study shock scattering, demonstrate the
stability of the shock waves, and calculate the anomalous exponents. We comment
on the possibility of finite time blowup singularities.Comment: 37 pages, 7 figure
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Since The Start Of The Vaccines For Children Program, Uptake Has Increased, And Most Disparities Have Decreased
The Vaccines for Children program is a US government intervention aimed at increasing vaccination uptake by removing financial barriers that may prevent US children from accessing vaccinations. This study examined the impact that this intervention had on race and ethnicity–related and income-related disparities for diphtheria-tetanus-acellular pertussis, measles-mumps-rubella, and polio vaccinations, using data from the National Immunization Survey, 1995–2013. Vaccination rates increased across all races, ethnicities, and income groups following the introduction of the Vaccines for Children program. Disparities among race and ethnic groups narrowed considerably over time since the introduction of the vaccine program, although income-related disparities changed at different rates within racial and ethnic groups and in some cases increased. Government interventions aimed solely at reducing certain financial barriers to vaccination may fail to address other important aspects of cost or perceived benefits that influence vaccination uptake, especially among poorer children
SOFIA FORCAST Grism Study of the Mineralogy of Dust in the Winds of Proto-planetary Nebulae: RV Tauri Stars and SRd Variables
We present a SOFIA FORCAST grism spectroscopic survey to examine the mineralogy of the circumstellar dust
in a sample of post-asymptotic giant branch (post-AGB) yellow supergiants that are believed to be the precursors
of planetary nebulae. Our mineralogical model of each star indicates the presence of both carbon-rich and oxygenrich dust species—contrary to simple dredge-up models—with a majority of the dust in the form of amorphous
carbon and graphite. The oxygen-rich dust is primarily in the form of amorphous silicates. The spectra do not
exhibit any prominent crystalline silicate emission features. For most of the systems, our analysis suggests that the
grains are relatively large and have undergone significant processing, supporting the hypothesis that the dust is
confined to a Keplerian disk and that we are viewing the heavily processed, central regions of the disk from a
nearly face-on orientation. These results help to determine the physical properties of the post-AGB circumstellar
environment and to constrain models of post-AGB mass loss and planetary nebula formatio
Low-Energy Theorems from Holography
In the context of gauge/gravity duality, we verify two types of gauge theory
low-energy theorems, the dilation Ward identities and the decoupling of heavy
flavor. First, we provide an analytic proof of non-trivial dilation Ward
identities for a theory holographically dual to a background with gluon
condensate (the self-dual Liu--Tseytlin background). In this way an important
class of low-energy theorems for correlators of different operators with the
trace of the energy-momentum tensor is established, which so far has been
studied in field theory only. Another low-energy relationship, the so-called
decoupling theorem, is numerically shown to hold universally in three
holographic models involving both the quark and the gluon condensate. We show
this by comparing the ratio of the quark and gluon condensates in three
different examples of gravity backgrounds with non-trivial dilaton flow. As a
by-product of our study, we also obtain gauge field condensate contributions to
meson transport coefficients.Comment: 32 pages, 4 figures, two references added, typos remove
Sum rules, plasma frequencies and Hall phenomenology in holographic plasmas
We study the AC optical and hall conductivities of Dp/Dq-branes intersections
in the probe approximation and use sum-rules to study various associated
transport coefficients. We determine that the presence of massive fundamental
matter, as compared to massless fundamental matter described holographically by
a theory with no dimensional defects, reduces the plasma frequency. We further
show that this is not the case when the brane intersections include defects. We
discuss in detail how to implement correctly the regularization of retarded
Green's functions so that the dispersion relations are satisfied and the low
energy behaviour of the system is physically realistic.Comment: 25 pages, 5 figures. v2.minor changes, published versio
Collective Excitations of Holographic Quantum Liquids in a Magnetic Field
We use holography to study N=4 supersymmetric SU(Nc) Yang-Mills theory in the
large-Nc and large-coupling limits coupled to a number Nf << Nc of
(n+1)-dimensional massless supersymmetric hypermultiplets in the Nc
representation of SU(Nc), with n=2,3. We introduce a temperature T, a baryon
number chemical potential mu, and a baryon number magnetic field B, and work in
a regime with mu >> T,\sqrt{B}. We study the collective excitations of these
holographic quantum liquids by computing the poles in the retarded Green's
function of the baryon number charge density operator and the associated peaks
in the spectral function. We focus on the evolution of the collective
excitations as we increase the frequency relative to T, i.e. the
hydrodynamic/collisionless crossover. We find that for all B, at low
frequencies the tallest peak in the spectral function is associated with
hydrodynamic charge diffusion. At high frequencies the tallest peak is
associated with a sound mode similar to the zero sound mode in the
collisionless regime of a Landau Fermi liquid. The sound mode has a gap
proportional to B, and as a result for intermediate frequencies and for B
sufficiently large compared to T the spectral function is strongly suppressed.
We find that the hydrodynamic/collisionless crossover occurs at a frequency
that is approximately B-independent.Comment: 45 pages, 8 png and 47 pdf images in 22 figure
Neighbourhood, Route and Workplace-Related Environmental Characteristics Predict Adults' Mode of Travel to Work
Commuting provides opportunities for regular physical activity which can reduce the risk of chronic disease. Commuters' mode of travel may be shaped by their environment, but understanding of which specific environmental characteristics are most important and might form targets for intervention is limited. This study investigated associations between mode choice and a range of objectively assessed environmental characteristics.Participants in the Commuting and Health in Cambridge study reported where they lived and worked, their usual mode of travel to work and a variety of socio-demographic characteristics. Using geographic information system (GIS) software, 30 exposure variables were produced capturing characteristics of areas around participants' homes and workplaces and their shortest modelled routes to work. Associations between usual mode of travel to work and personal and environmental characteristics were investigated using multinomial logistic regression.Of the 1124 respondents, 50% reported cycling or walking as their usual mode of travel to work. In adjusted analyses, home-work distance was strongly associated with mode choice, particularly for walking. Lower odds of walking or cycling rather than driving were associated with a less frequent bus service (highest versus lowest tertile: walking OR 0.61 [95% CI 0.20–1.85]; cycling OR 0.43 [95% CI 0.23–0.83]), low street connectivity (OR 0.22, [0.07–0.67]; OR 0.48 [0.26–0.90]) and free car parking at work (OR 0.24 [0.10–0.59]; OR 0.55 [0.32–0.95]). Participants were less likely to cycle if they had access to fewer destinations (leisure facilities, shops and schools) close to work (OR 0.36 [0.21–0.62]) and a railway station further from home (OR 0.53 [0.30–0.93]). Covariates strongly predicted travel mode (pseudo r-squared 0.74).Potentially modifiable environmental characteristics, including workplace car parking, street connectivity and access to public transport, are associated with travel mode choice, and could be addressed as part of transport policy and infrastructural interventions to promote active commuting
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