An integrated system and framework for development of medical applications and products based on medical imaging data

Cranial defects which are caused by bone tumors or traffic accidents are treated by cranioplasty techniques. Cranioplasty implants are required to protect the underlying brain, correct major aesthetic deformities, or both. With the rapid develop-ment of computer graphics, medical image processing (MIP) and manufacturing technologies in recent decades, nowadays, personalised cranioplasty implants can be designed and made to improve the quality of cranial defect treatments. However, software tools for MIP and 3D modelling of implants are ex-pensive; and they normally require high technical skills. Espe-cially, the process of design and development of personalised cranioplasty implants normally requires a multidisciplinary team, including experts in MIP, 3D design and modelling, and Biomedical Engineering; this leads to challenges and difficulties for technology transfers and implementations in hospitals. This research is aimed at developing, in particular, cost-effective solutions and tools for design and modeling of personalised cranioplasty implants, and to simplify the design and modelling of implants, as well as to reduce the design and modeling time. In this way, surgeons and engineers can conveniently and easily design personalised cranioplasty implants, without the need of using complex MIP and CAD tools; and as a result the cost of implants will be minimised

Analysis of Kelly-optimal portfolios

We investigate the use of Kelly's strategy in the construction of an optimal portfolio of assets. For lognormally distributed asset returns, we derive approximate analytical results for the optimal investment fractions in various settings. We show that when mean returns and volatilities of the assets are small and there is no risk-free asset, the Kelly-optimal portfolio lies on Markowitz Efficient Frontier. Since in the investigated case the Kelly approach forbids short positions and borrowing, often only a small fraction of the available assets is included in the Kelly-optimal portfolio. This phenomenon, that we call condensation, is studied analytically in various model scenarios.Comment: 15 pages, 7 figures; extended list of references and some minor modification

The exactness of a general Skoda complex

We show that a Skoda complex with a general plurisubharmonic weight function is exact if its 'degree' is sufficiently large. This answers a question of Lazarsfeld and implies that not every integrally closed ideal is equal to a multiplier ideal even if we allow general plurisubharmonic weights for the multiplier ideal, extending the result of Lazarsfeld and Lee \cite{LL}.Comment: References added, exposition streamlined, to appear in Michigan Mathematical Journa

Diffraction problems for quasilinear parabolic systems with boundary intersecting interfaces

Stability of Unilateral Posterior Crossbite Correction in the Mixed Dentition - an RCT-study with 3-year Follow-Up. Aim: To compare and evaluate long-term stability of crossbite correction with Quad Helix or expansion plate in the mixed dentition. Methods: In this RCT-study 35 patients with unilateral posterior crossbite were randomized to be treated with either Quad Helix or expansion plate. The inclusion criteria were: mixed dentition, unilateral posterior crossbite, no sucking habits or previous orthodontic treatment. Stability was evaluated after 3 years by study cast measurements. Twenty subjects with normal occlusion were included as controls. Success rate, maxillary and mandibular transverse dimensions, overjet, overbite and arch length were registered. Results: Stability was equal for the two treatment methods. Small, albeit significant, differences between the groups were assessed with reference to transverse dimensions. No significant difference was seen for overjet and overbite. The treated patients never reached the same transversal width as the normal control group. Conclusions: The long-term stability of posterior crossbite correction with Quad helix and expansion plate was equal. The maxillary width was greater in the control group than the treated groups

Price regulation, new entry, and information shock on pharmaceutical market in Taiwan: a nationwide data-based study from 2001 to 2004

<p>Abstract</p> <p>Background</p> <p>Using non-steroidal anti-inflammatory drugs (NSAIDs) as a case, we used Taiwan's National Health Insurance (NHI) database, to empirically explore the association between policy interventions (price regulation, new drug entry, and an information shock) and drug expenditures, utilization, and market structure between 2001 and 2004.</p> <p>Methods</p> <p>All NSAIDs prescribed in ambulatory visits in the NHI system during our study period were included and aggregated quarterly. Segmented regression analysis for interrupted time series was used to examine the associations between two price regulations, two new drug entries (cyclooxygennase-2 inhibitors) and the rofecoxib safety signal and expenditures and utilization of all NSAIDs. Herfindahl index (HHI) was applied to further examine the association between these interventions and market structure of NSAIDs.</p> <p>Results</p> <p>New entry was the only variable that was significantly correlated with changes of expenditures (positive change, p = 0.02) and market structure of the NSAIDs market in the NHI system. The correlation between price regulation (first price regulation, p = 0.62; second price regulation, p = 0.26) and information shock (p = 0.31) and drug expenditure were not statistically significant. There was no significant change in the prescribing volume of NSAIDs per rheumatoid arthritis (RA) or osteoarthritis (OA) ambulatory visit during the observational period. The market share of NSAIDs had also been largely substituted by these new drugs up to 50%, in a three-year period and resulted in a more concentrated market structure (HHI 0.17).</p> <p>Conclusions</p> <p>Our empirical study found that new drug entry was the main driving force behind escalating drug spending, especially by altering the market share.</p

Amyand's Hernia – Case Report and Review of the Literature

Amyand's hernia is an extremely rare condition in which the appendix is positioned in the inguinal hernia sac. Acute appendicitis is much less common in this situation and few reports are found in the literature. We report a case of acute appendicitis with the tip of the appendix incarcerated outside the external ring of the right groin. A mobilized cecum and ascending colon were noticed during surgery. We conducted a review of the literature, emphasizing possible causes and suggesting a predisposing factor for the condition

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies

PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Patterns of lung cancer mortality in 23 countries: Application of the Age-Period-Cohort model

BACKGROUND: Smoking habits do not seem to be the main explanation of the epidemiological characteristics of female lung cancer mortality in Asian countries. However, Asian countries are often excluded from studies of geographical differences in trends for lung cancer mortality. We thus examined lung cancer trends from 1971 to 1995 among men and women for 23 countries, including four in Asia. METHODS: International and national data were used to analyze lung cancer mortality from 1971 to 1995 in both sexes. Age-standardized mortality rates (ASMR) were analyzed in five consecutive five-year periods and for each five-year age group in the age range 30 to 79. The age-period-cohort (APC) model was used to estimate the period effect (adjusted for age and cohort effects) for mortality from lung cancer. RESULTS: The sex ratio of the ASMR for lung cancer was lower in Asian countries, while the sex ratio of smoking prevalence was higher in Asian countries. The mean values of the sex ratio of the ASMR from lung cancer in Taiwan, Hong Kong, Singapore, and Japan for the five 5-year period were 2.10, 2.39, 3.07, and 3.55, respectively. These values not only remained quite constant over each five-year period, but were also lower than seen in the western countries. The period effect, for lung cancer mortality as derived for the 23 countries from the APC model, could be classified into seven patterns. CONCLUSION: Period effects for both men and women in 23 countries, as derived using the APC model, could be classified into seven patterns. Four Asian countries have a relatively low sex ratio in lung cancer mortality and a relatively high sex ratio in smoking prevalence. Factors other than smoking might be important, especially for women in Asian countries

Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells

Epstein-Barr virus (EBV) is implicated in the pathogenesis of multiple human tumours of lymphoid and epithelial origin. The virus infects and immortalizes B cells establishing a persistent latent infection characterized by varying patterns of EBV latent gene expression (latency 0, I, II and III). The CDK1 activator, Response Gene to Complement-32 (RGC-32, C13ORF15), is overexpressed in colon, breast and ovarian cancer tissues and we have detected selective high-level RGC-32 protein expression in EBV-immortalized latency III cells. Significantly, we show that overexpression of RGC-32 in B cells is sufficient to disrupt G2 cell-cycle arrest consistent with activation of CDK1, implicating RGC-32 in the EBV transformation process. Surprisingly, RGC-32 mRNA is expressed at high levels in latency I Burkitt's lymphoma (BL) cells and in some EBV-negative BL cell-lines, although RGC-32 protein expression is not detectable. We show that RGC-32 mRNA expression is elevated in latency I cells due to transcriptional activation by high levels of the differentially expressed RUNX1c transcription factor. We found that proteosomal degradation or blocked cytoplasmic export of the RGC-32 message were not responsible for the lack of RGC-32 protein expression in latency I cells. Significantly, analysis of the ribosomal association of the RGC-32 mRNA in latency I and latency III cells revealed that RGC-32 transcripts were associated with multiple ribosomes in both cell-types implicating post-initiation translational repression mechanisms in the block to RGC-32 protein production in latency I cells. In summary, our results are the first to demonstrate RGC-32 protein upregulation in cells transformed by a human tumour virus and to identify post-initiation translational mechanisms as an expression control point for this key cell-cycle regulator