42 research outputs found

    Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]

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    Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form multiple infectious prion conformations, also known as strains or variants, encoding unique biological phenotypes, and to establish and overcome prion species (transmission) barriers. In this Perspective, we highlight recent studies of the yeast prion [PSI+], using various biochemical and structural methods, that have begun to illuminate the molecular mechanisms by which self-perpetuating prions encipher such biological activities. We also discuss several aspects of prion conformational change and structure that remain either unknown or controversial, and we propose approaches to accelerate the understanding of these enigmatic, infectious conformers

    Using Nearpod in Elementary Guided Reading Groups

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    A student teacher placed at a school with a high English Language Learner population used mini iPads, and an application called Nearpod, during guided reading instruction. Groups of students in a fourth grade classroom used this application. The students and the teacher were interviewed to determine the benefits and challenges of this approach. An analysis of data revealed that all of the students found this type of guided reading to be beneficial and motivating in learning the content presented through the application. Students also explained how they could transfer the knowledge gained into their independent work. The teacher discussed how it improved organization in a guided reading group, but how careful consideration and planning must be done to ensure the technology will work properly during guided reading. It is recommended that the Nearpod application be used in guided reading lessons because of its user-friendliness, ability to engage students, and monitor their progress. [ABSTRACT FROM AUTHOR

    A Randomized Controlled Study of Writing Interventions on College Women’s Positive Body Image

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    College women are at risk for body dissatisfaction, but enhancing the positive aspects of body image can serve as a protective factor. Self-compassion has been associated with body appreciation and may protect against negative body image. This study tested the effect of a self-compassion writing intervention on positive body image and affect and explored self-compassion as a mediator between writing group and positive body image. We used a randomized controlled design to compare self-compassion writing (n = 51), traditional expressive writing (n = 50), and control writing (n = 51) interventions in college women. Participants were mostly European-American (82%) with a mean age of 19. Participants wrote online for 20 min once a week for three consecutive weeks. Results indicated that negative and positive affect decreased for all three groups. There were no differences between groups on positive body image or affect; however, the self-compassion writing group reported greater increases in self-compassion (F = 3.48, p \u3c 0.05, ηp2 = 0.05). Moreover, mediator models revealed that the effect of group (self-compassion vs. traditional/control writing) on body appreciation and body image quality of life was mediated by self-compassion. Overall, the findings indicate that self-compassion writing increased self-compassion, and greater increases in self-compassion were associated with greater increases in positive body image and positive affect
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