5,843 research outputs found
The peripartum management of a 32-year-old patient presenting at 34 weeks’ gestation with unrepaired cyanotic heart disease
CITATION: Rossouw, J. N., et al. 2018. The peripartum management of a 32-year-old patient presenting at 34 weeks’ gestation with unrepaired cyanotic heart disease. South African Journal of Obstetrics and Gynaecology, 24(2):36-39, doi:10.7196/sajog.1265.The original publication is available at http://www.sajog.org.zaENGLISH ABSTRACT: Unrepaired cyanotic heart disease is considered a high-risk lesion owing to the consequent increase in maternal and fetal complications. In the presence of pulmonary hypertension, maternal mortality approaching 50% has been reported, and pregnancy is therefore considered contraindicated. We present a case of a 32-year-old woman presenting at 34 weeks’ gestation in heart failure due to newly diagnosed cyanotic complex cardiac disease. The diagnosis of left atrial isomerism with a common atrium, single atrioventricular valve, and a restrictive ventricular septum defect was made. Cyanosis was due to mixing at atrial level, without features of Eisenmenger’s syndrome. Her intrapartum multidisciplinary management is described in detail. The patient was discharged home in a condition similar to her baseline, together with her healthy neonate.http://www.sajog.org.za/index.php/SAJOG/article/view/1265Publisher's versio
Supramolecular Assembly of Pyrene-DNA Conjugates into Columnar Vesicles
This poster describes the supramolecular assembly of DNA conjugates functionalized with pyrene sticky-ends. After hybridization, the 3’-end modified DNA single strands self-assembled into vesicles with diameters of 50–200 nm. Columnar packed aggregated and multilamellar vesicles were observed by cryo-EM
SM and MSSM Higgs Boson Production: Spectra at large transverse Momentum
Strategies for Higgs boson searches require the knowledge of the total
production cross section and the transverse momentum spectrum. The large
transverse momentum spectrum of the Higgs boson produced in gluon fusion can be
quite different in the Standard Model and the Minimal Supersymmetric Standard
Model. In this paper we present a comparison of the Higgs transverse momentum
spectrum obtained using the PYTHIA event generator and the HIGLU program as
well as the program HQT, which includes NLO corrections and a soft gluon
resummation for the region of small transverse momenta. While the shapes of the
spectra are similar for the Standard Model, significant differences are
observed in the spectra of Minimal Supersymmetric Standard Model benchmark
scenarios with large tan(beta).Comment: 8 pages, 13 figure
Production of the neutral top-pion in association with a high- jet at the
In the framework of the topcolor-assisted technicolor model, we study
production of the neutral top-pion in association with a
high- jet at the , which proceeds via the partonic processes
, ,
, , and . We find
that it is very challenging to detect the neutral top-pion via
the process , while the
possible signatures of might be detected via the process
at the .Comment: 13 pages, 4 figures; typos correcte
Signal height in silicon pixel detectors irradiated with pions and protons
Pixel detectors are used in the innermost part of multi purpose experiments
at the Large Hadron Collider (LHC) and are therefore exposed to the highest
fluences of ionising radiation, which in this part of the detectors consists
mainly of charged pions. The radiation hardness of the detectors has thoroughly
been tested up to the fluences expected at the LHC. In case of an LHC upgrade
the fluence will be much higher and it is not yet clear up to which radii the
present pixel technology can be used. In order to establish such a limit, pixel
sensors of the size of one CMS pixel readout chip (PSI46V2.1) have been bump
bonded and irradiated with positive pions up to 6E14 Neq/cm^2 at PSI and with
protons up to 5E15 Neq/cm^2. The sensors were taken from production wafers of
the CMS barrel pixel detector. They use n-type DOFZ material with a resistance
of about 3.7kOhm cm and an n-side read out. As the performance of silicon
sensors is limited by trapping, the response to a Sr-90 source was
investigated. The highly energetic beta-particles represent a good
approximation to minimum ionising particles. The bias dependence of the signal
for a wide range of fluences will be presented.Comment: Contribution to the 7th International Conference on Radiation Effects
on Semiconductor Materials, Detectors and Devices October 15-17, 2008
Firenze, Ital
Nondestructive in-line sub-picomolar detection of magnetic nanoparticles in flowing complex fluids
Over the last decades, the use of magnetic nanoparticles in research and
commercial applications has increased dramatically. However, direct detection
of trace quantities remains a challenge in terms of equipment cost, operating
conditions and data acquisition times, especially in flowing conditions within
complex media. Here we present the in-line, non-destructive detection of
magnetic nanoparticles using high performance atomic magnetometers at ambient
conditions in flowing media. We achieve sub-picomolar sensitivities measuring
30 nm ferromagnetic iron and cobalt nanoparticles that are suitable for
biomedical and industrial applications, under flowing conditions in water and
whole blood. Additionally, we demonstrate real-time surveillance of the
magnetic separation of nanoparticles from water and whole blood. Overall our
system has the merit of inline direct measurement of trace quantities of
ferromagnetic nanoparticles with so far unreached sensitivities and could be
applied in the biomedical field (diagnostics and therapeutics) but also in the
industrial sector
Linear Peptides-A Combinatorial Innovation in the Venom of Some Modern Spiders
In the venom of spiders, linear peptides (LPs), also called cytolytical or antimicrobial peptides, represent a largely neglected group of mostly membrane active substances that contribute in some spider species considerably to the killing power of spider venom. By next-generation sequencing venom gland transcriptome analysis, we investigated 48 spider species from 23 spider families and detected LPs in 20 species, belonging to five spider families (Ctenidae, Lycosidae, Oxyopidae, Pisauridae, and Zodariidae). The structural diversity is extraordinary high in some species: the lynx spider Oxyopes heterophthalmus contains 62 and the lycosid Pardosa palustris 60 different LPs. In total, we identified 524 linear peptide structures and some of them are in lycosids identical on amino acid level. LPs are mainly encoded in complex precursor structures in which, after the signal peptide and propeptide, 13 or more LPs (Hogna radiata) are connected by linkers. Besides Cupiennius species, also in Oxyopidae, posttranslational modifications of some precursor structures result in the formation of two-chain peptides. It is obvious that complex precursor structures represent a very suitable and fast method to produce a high number and a high diversity of bioactive LPs as economically as possible. At least in Lycosidae, Oxyopidae, and in the genus Cupiennius, LPs reach very high Transcripts Per Kilobase Million values, indicating functional importance within the envenomation process
The Physics of Heavy Flavours at SuperB
This is a review of the SuperB project, covering the accelerator, detector,
and highlights of the broad physics programme. SuperB is a flavour factory
capable of performing precision measurements and searches for rare and
forbidden decays of , , and
particles. These results can be used to test fundamental symmetries and
expectations of the Standard Model, and to constrain many different
hypothesised types of new physics. In some cases these measurements can be used
to place constraints on the existence of light dark matter and light Higgs
particles with masses below . The potential impact of the
measurements that will be made by SuperB on the field of high energy physics is
also discussed in the context of data taken at both high energy in the region
around the \Upsilon({\mathrm{4S}})$, and near charm threshold.Comment: 49 pages, topical review submitted to J. Phys
The Discovery Potential of a Super B Factory
The Proceedings of the 2003 SLAC Workshops on flavor physics with a high
luminosity asymmetric e+e- collider. The sensitivity of flavor physics to
physics beyond the Standard Model is addressed in detail, in the context of the
improvement of experimental measurements and theoretical calculations.Comment: 476 pages. Printed copies may be obtained by request to
[email protected] . arXiv admin note: v2 appears to be identical to v
Multi-Jet Event Rates in Deep Inelastic Scattering and Determination of the Strong Coupling Constant
Jet event rates in deep inelastic ep scattering at HERA are investigated
applying the modified JADE jet algorithm. The analysis uses data taken with the
H1 detector in 1994 and 1995. The data are corrected for detector and
hadronization effects and then compared with perturbative QCD predictions using
next-to-leading order calculations. The strong coupling constant alpha_S(M_Z^2)
is determined evaluating the jet event rates. Values of alpha_S(Q^2) are
extracted in four different bins of the negative squared momentum
transfer~\qq in the range from 40 GeV2 to 4000 GeV2. A combined fit of the
renormalization group equation to these several alpha_S(Q^2) values results in
alpha_S(M_Z^2) = 0.117+-0.003(stat)+0.009-0.013(syst)+0.006(jet algorithm).Comment: 17 pages, 4 figures, 3 tables, this version to appear in Eur. Phys.
J.; it replaces first posted hep-ex/9807019 which had incorrect figure 4
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