2,738 research outputs found

    The great dichotomy of the Solar System: small terrestrial embryos and massive giant planet cores

    Full text link
    The basic structure of the solar system is set by the presence of low-mass terrestrial planets in its inner part and giant planets in its outer part. This is the result of the formation of a system of multiple embryos with approximately the mass of Mars in the inner disk and of a few multi-Earth-mass cores in the outer disk, within the lifetime of the gaseous component of the protoplanetary disk. What was the origin of this dichotomy in the mass distribution of embryos/cores? We show in this paper that the classic processes of runaway and oligarchic growth from a disk of planetesimals cannot explain this dichotomy, even if the original surface density of solids increased at the snowline. Instead, the accretion of drifting pebbles by embryos and cores can explain the dichotomy, provided that some assumptions hold true. We propose that the mass-flow of pebbles is two-times lower and the characteristic size of the pebbles is approximately ten times smaller within the snowline than beyond the snowline (respectively at heliocentric distance r<ricer<r_{ice} and r>ricer>r_{ice}, where ricer_{ice} is the snowline heliocentric distance), due to ice sublimation and the splitting of icy pebbles into a collection of chondrule-size silicate grains. In this case, objects of original sub-lunar mass would grow at drastically different rates in the two regions of the disk. Within the snowline these bodies would reach approximately the mass of Mars while beyond the snowline they would grow to ∌20\sim 20 Earth masses. The results may change quantitatively with changes to the assumed parameters, but the establishment of a clear dichotomy in the mass distribution of protoplanets appears robust, provided that there is enough turbulence in the disk to prevent the sedimentation of the silicate grains into a very thin layer.Comment: In press in Icaru

    Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis

    Get PDF
    Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo. Deletion of the hypoxia response element of the promoter region of the gene encoding VEGF in mice causes a reduction in neural VEGF expression, and results in adult-onset motor neurone degeneration that resembles amyotrophic lateral sclerosis (ALS). Investigating the molecular pathways to neurodegeneration in the VEGF(delta/delta) mouse model of ALS may improve understanding of the mechanisms of motor neurone death in the human disease. Results: Microarray analysis was used to determine the transcriptional profile of laser captured spinal motor neurones of transgenic and wild-type littermates at 3 time points of disease. 324 genes were significantly differentially expressed in motor neurones of presymptomatic VEGF(delta/delta) mice, 382 at disease onset, and 689 at late stage disease. Massive transcriptional downregulation occurred with disease progression, associated with downregulation of genes involved in RNA processing at late stage disease. VEGF(delta/delta) mice showed reduction in expression, from symptom onset, of the cholesterol synthesis pathway, and genes involved in nervous system development, including axonogenesis, synapse formation, growth factor signalling pathways, cell adhesion and microtubule-based processes. These changes may reflect a reduced capacity of VEGF(delta/delta) mice for maintenance and remodelling of neuronal processes in the face of demands of neural plasticity. The findings are supported by the demonstration that in primary motor neurone cultures from VEGF(delta/delta) mice, axon outgrowth is significantly reduced compared to wild-type littermates. Conclusions: Downregulation of these genes involved in axon outgrowth and synapse formation in adult mice suggests a hitherto unrecognized role of VEGF in the maintenance of neuronal circuitry. Dysregulation of VEGF may lead to neurodegeneration through synaptic regression and dying-back axonopathy

    Fingermark age determinations: Legal considerations, review of the literature and practical propositions.

    Get PDF
    The question of the age of fingermarks is often raised in investigations and trials when suspects admit that they have left their fingermarks at a crime scene but allege that the contact occurred at a different time than the crime and for legal reasons. In the first part of this review article, examples from American appellate court cases will be used to demonstrate that there is a lack of consensus among American courts regarding the admissibility and weight of testimony from expert witnesses who provide opinions about the age of fingermarks. Of course, these issues are not only encountered in America but have also been reported elsewhere, for example in Europe. The disparity in the way fingermark dating cases were managed in these examples is probably due to the fact that no methodology has been validated and accepted by the forensic science community so far. The second part of this review article summarizes the studies reported on fingermark dating in the literature and highlights the fact that most proposed methodologies still suffer from limitations preventing their use in practice. Nevertheless, several approaches based on the evolution of aging parameters detected in fingermark residue over time appear to show promise for the fingermark dating field. Based on these approaches, the definition of a formal methodological framework for fingermark dating cases is proposed in order to produce relevant temporal information. This framework identifies which type of information could and should be obtained about fingermark aging and what developments are still required to scientifically address dating issues

    Afrikaanse vryheidsliedjies as herkonstruksie van Afrikaneridentiteit: ’n ideologies-kritiese perspektief

    Get PDF
    Afrikaans freedom songs as a reconstruction of Afrikaner identity Media polemics that centred on Afrikaner identity and language proliferated in Afrikaans newspapers of the early 2000s. It illustrates that although more than a decade has passed since democratisation, identity politics are still an important South African topic and renegotiation therefore continues. This article discusses the role of Afrikaans freedom songs as a reconstruction of white Afrikaner identity with the specific aim of establishing a point of departure for an ideology-critical theorising of the topic. In this regard, the interpretative tools of metaphor analysis and ideology critique of Johann Visagie (1996) are applied within the broader framework of the so-called Critical Theory. The five dominant postapartheid narratives recorded by Melissa Steyn (2001) serve as starting point for this study. The selection of freedom songs is related to specific constructions of “whiteness” portrayed in the mentioned narratives
    • 

    corecore