Emerging role of G protein-coupled receptors in microvascular myogenic tone

Blood flow autoregulation results from the ability of resistance arteries to reduce or increase their diameters in response to changes in intravascular pressure. The mechanism by which arteries maintain a constant blood flow to organs over a range of pressures relies on this myogenic response, which defines the intrinsic property of the smooth muscle to contract in response to stretch. The resistance to flow created by myogenic tone (MT) prevents tissue damage and allows the maintenance of a constant perfusion, despite fluctuations in arterial pressure. Interventions targeting MT may provide a more rational therapeutic approach in vascular disorders, such as hypertension, vasospasm, chronic heart failure, or diabetes. Despite its early description by Bayliss in 1902, the cellular and molecular mechanisms underlying MT remain poorly understood. We now appreciate that MT requires a complex mechanotransduction converting a physical stimulus (pressure) into a biological response (change in vessel diameter). Although smooth muscle cell depolarization and a rise in intracellular calcium concentration are recognized as cornerstones of the myogenic response, the role of wall strain-induced formation of vasoactive mediators is less well established. The vascular system expresses a large variety of Class 1 G protein-coupled receptors (GPCR) activated by an eclectic range of chemical entities, including peptides, lipids, nucleotides, and amines. These messengers can function in blood vessels as vasoconstrictors. This review focuses on locally generated GPCR agonists and their proposed contributions to MT. Their interplay with pivotal G(q-11) and G(12-13) protein signalling is also discussed

A Population of Short-Period Variable Quasars from PTF as Supermassive Black Hole Binary Candidates

Supermassive black hole binaries (SMBHBs) at sub-parsec separations should be common in galactic nuclei, as a result of frequent galaxy mergers. Hydrodynamical simulations of circumbinary discs predict strong periodic modulation of the mass accretion rate on time-scales comparable to the orbital period of the binary. As a result, SMBHBs may be recognized by the periodic modulation of their brightness. We conducted a statistical search for periodic variability in a sample of 35,383 spectroscopically confirmed quasars in the photometric database of the Palomar Transient Factory (PTF). We analysed Lomb-Scargle periodograms and assessed the significance of our findings by modeling each individual quasar's variability as a damped random walk (DRW). We identified 50 quasars with significant periodicity beyond the DRW model, typically with short periods of a few hundred days. We find 33 of these to remain significant after a re-analysis of their periodograms including additional optical data from the intermediate-PTF and the Catalina Real-Time Transient Survey (CRTS). Assuming that the observed periods correspond to the redshifted orbital periods of SMBHBs, we conclude that our findings are consistent with a population of unequal-mass SMBHBs, with a typical mass ratio as low as q = M2/M1 ~ 0.01.Comment: MNRAS (accepted), new section 4.

Electron-impact excitation of X 1Sigma_g⁺(v[double-prime]=0) to the a[double-prime] 1Sigma_g⁺, b 1Piu, c3 1Piu, o3 1Piu, b[prime] 1Sigma_u⁺, c₄^[prime] 1Sigma_u⁺, G 3Piu, and F 3Piu states of molecular nitrogen

Measurements of differential cross sections (DCSs) for electron-impact excitation of the a[double-prime] 1Sigmag+, b 1Piu, c3 1Piu, o3 1Piu, b[prime] 1Sigmau+, c4[prime] 1Sigmau+, G 3Piu, and F 3Piu states in N2 from the X 1Sigmag+(v[double-prime]=0) ground level are presented. The DCSs were obtained from energy-loss spectra in the region of 12 to 13.82 eV measured at incident energies of 17.5, 20, 30, 50, and 100 eV and for scattering angles ranging from 2° to 130°. The analysis of the spectra follows a different algorithm from that employed in a previous study of N2 for the valence states [Khakoo et al. Phys. Rev. A 71, 062703 (2005)], since the 1Piu and 1Sigmau+ states form strongly interacting Rydberg-valence series. The results are compared with existing data

Science Validation of the Spitzer Source List

The Spitzer Science Center will produce a source list (SL) of photometry for a large subset of imaging data in the Spitzer Heritage Archive (SHA). The list will enable a large range of science projects. The primary requirement on the SL is very high reliability — with areal coverage, completeness and limiting depth being secondary considerations. The SHA at the NASA Infrared Science Archive (IRSA) will serve the SL as an enhanced data product. The SL will include data from the four channels of IRAC (3–8 microns) and the 24 micron channel of MIPS. The Source List will include image products (mosaics) and photometric data for Spitzer observations of about 1500 square degrees and include around 30 million sources. We describe ongoing science validation of the Spitzer Source List, and discuss the range of use cases which will be supported

The Spitzer Source List

The Spitzer Science Center will produce a source list (SL) of photometry for a large subset of imaging data in the Spitzer Heritage Archive (SHA). The list will enable a large range of science projects. The primary requirement on the SL is very high reliability, with areal coverage, completeness and limiting depth being secondary considerations. The SHA at the NASA Infrared Science Archive (IRSA) will serve the SL as an enhanced data product. The SL will include data from the four channels of IRAC (3–8 microns) and the 24 micron channel of MIPS. The Source List will include image products (mosaics) and photometric data for Spitzer observations of about 1500 square degrees and include around 30 million sources. We describe the plans and timeline for development of the Spitzer Source List. We demonstrate the verification of the Source List pipeline using Spitzer Legacy catalogs at "truth tables". Finally, we discuss the range of use cases which will be supported

An Optical Search for New Outbursting Low Mass X-Ray Binaries

Transient Low-Mass X-ray binaries (LMXBs) are discovered largely by X-ray and gamma-ray all-sky monitors. The X-ray outburst is also accompanied by an optical brightening, which empirically can precede detection of X-rays. Newly sensitive optical synoptic surveys may offer a complementary pathway for discovery, and potential for insight into the initial onset and propagation of the thermal instability that leads to the ionization of the accretion disk. We use the Zwicky Transient Facility (ZTF) alert stream to perform a comprehensive search at optical wavelengths for previously undiscovered outbursting LMXBs. Our pipeline first crossmatches the positions of the alerts to cataloged X-ray sources, and then analyzes the 30-day lightcurve of matched alerts by thresholding on differences with an 8-day exponentially weighted moving average. In addition to an nineteen month-long live search, we ran our pipeline over four years of ZTF archival data, recovering 4 known LMXBs. We also independently detected an outburst of MAXI J1957+032 in the live search and found the first outburst of Swift J1943.4+0228, an unclassified X-ray transient, in 10 years. Using Monte Carlo simulations of the Galactic LMXB population, we estimate that 29% of outbursting LMXBs are detectable by ZTF and that 4.4% of LMXBs would be present in the crossmatched X-ray catalogs, giving an estimated Galactic population of $3390^{+3980}_{-1930}$. We estimate that our current pipeline can detect 1.3% of all outbursting LMXBs, including those previously unknown, but that Rubin Observatory's Legacy Survey of Space and Time (LSST) will be able to detect 43% of outbursting LMXBs.Comment: 17 pages, 10 figures, Accepted for publication in Ap

Interaction-powered supernovae: Rise-time vs. peak-luminosity correlation and the shock-breakout velocity

Interaction of supernova (SN) ejecta with the optically thick circumstellar medium (CSM) of a progenitor star can result in a bright, long-lived shock breakout event. Candidates for such SNe include Type IIn and superluminous SNe. If some of these SNe are powered by interaction, then there should be a relation between their peak luminosity, bolometric light-curve rise time, and shock-breakout velocity. Given that the shock velocity during shock breakout is not measured, we expect a correlation, with a significant spread, between the rise time and the peak luminosity of these SNe. Here, we present a sample of 15 SNe IIn for which we have good constraints on their rise time and peak luminosity from observations obtained using the Palomar Transient Factory. We report on a possible correlation between the R-band rise time and peak luminosity of these SNe, with a false-alarm probability of 3%. Assuming that these SNe are powered by interaction, combining these observables and theory allows us to deduce lower limits on the shock-breakout velocity. The lower limits on the shock velocity we find are consistent with what is expected for SNe (i.e., ~10^4 km/s). This supports the suggestion that the early-time light curves of SNe IIn are caused by shock breakout in a dense CSM. We note that such a correlation can arise from other physical mechanisms. Performing such a test on other classes of SNe (e.g., superluminous SNe) can be used to rule out the interaction model for a class of events.Comment: Accepted to ApJ, 6 page

An outburst from a massive star 40 days before a supernova explosion

Various lines of evidence suggest that very massive stars experience extreme mass-loss episodes shortly before they explode as a supernova. Interestingly, several models predict such pre-explosion outbursts. Establishing a causal connection between these mass-loss episodes and the final supernova explosion will provide a novel way to study pre-supernova massive-star evolution. Here we report on observations of a remarkable mass-loss event detected 40 days prior to the explosion of the Type IIn supernova SN 2010mc (PTF 10tel). Our photometric and spectroscopic data suggest that this event is a result of an energetic outburst, radiating at least 6x10^47 erg of energy, and releasing about 0.01 Solar mass at typical velocities of 2000 km/s. We show that the temporal proximity of the mass-loss outburst and the supernova explosion implies a causal connection between them. Moreover, we find that the outburst luminosity and velocity are consistent with the predictions of the wave-driven pulsation model and disfavor alternative suggestions.Comment: Nature 494, 65, including supplementary informatio

The Palomar Transient Factory photometric catalog 1.0

We construct a photometrically calibrated catalog of non-variable sources from the Palomar Transient Factory (PTF) observations. The first version of this catalog presented here, the PTF photometric catalog 1.0, contains calibrated R_PTF-filter magnitudes for about 21 million sources brighter than magnitude 19, over an area of about 11233 deg^2. The magnitudes are provided in the PTF photometric system, and the color of a source is required in order to convert these magnitudes into other magnitude systems. We estimate that the magnitudes in this catalog have typical accuracy of about 0.02 mag with respect to magnitudes from the Sloan Digital Sky Survey. The median repeatability of our catalog's magnitudes for stars between 15 and 16 mag, is about 0.01 mag, and it is better than 0.03 mag for 95% of the sources in this magnitude range. The main goal of this catalog is to provide reference magnitudes for photometric calibration of visible light observations. Subsequent versions of this catalog, which will be published incrementally online, will be extended to a larger sky area and will also include g_PTF-filter magnitudes, as well as variability and proper motion information.Comment: 6 pages, 6 figures, PASP in pres