Long-range Angular Correlations On The Near And Away Side In P-pb Collisions At √snn=5.02 Tev

7191/Mar294

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Diabetes mellitus: pathophysiological changes and therap

Fenologia e produção da videira 'Niagara Rosada' conduzida em manjedoura na forma de y sob telado plástico durante as safras de inverno e de verão

Realizou-se experimento em vinhedo comercial de 'Niagara Rosada' conduzido em Y sob telado plástico, na região produtora de Louveira (SP), objetivando avaliar as variáveis fitotécnicas (produção, massa e tamanho dos cachos) e fenológicas, durante as safras de verão e de inverno. A produção, a massa dos cachos, o comprimento e a largura dos cachos mostraram uma tendência de serem superiores na safra de verão em relação à de inverno. Os valores de produtividade estimada variaram entre 30 e 35 t.ha-1 durante as safras de verão e entre 20 a 22 t.ha-1 para as de inverno. A duração de ciclo na safra de inverno (125 dias) foi menor em comparação com a de verão (140 dias)