Monoclonal gammopathy leading to blood hyperviscosity syndrome in a dog - case report

ABSTRACT Monoclonal gammopathy (MG) is rare in dogs and multiple myeloma (MM) is its main cause. This study reports the case of a female dog which presented MG associated with a MM and consequent blood hyperviscosity syndrome (HVS). Patient presented systemic hypertension, renal disease, chorioretinitis and secondary glaucoma due to HVS. Serological tests for leishmaniasis and for ehrlichiosis demonstrated negative and score 4 from 5, respectively. Non-regenerative anemia, thrombocytopenia, hyperproteinemia, hypoalbuminemia, hyperglobulinemia, creatinine and blood urea nitrogen (BUN) increases, hypercalcemia, hyperphosphatemia, proteinuria, decreased urinary density, and monoclonal peak of gamma globulins were observed. First myelogram identified 81% of medullary plasmacytosis which suggested MM. Plasmapheresis and chemotherapy with melphalan and prednisolone were performed with positive results. The treatment was effective with complete remission of HVS signs, medullary plasmocytosis reduction (21,8%) and malignant criteria decrease, as well as neoplastic control

Estudo retrospectivo de exames citológicos realizados em um Hospital Veterinário Escola em um período de cinco anos

The cytological exam is a practical diagnostic aplication which allows the detection of inflammatory, proliferative and infectious disturbances. In the present study, the results of cytological exams during six years were evaluated, determining the most common type of disorder (inflammatory, infectious, proliferative). Epidemiological aspects such as species, breed, sex and age were taken into account. 270 reviews were evaluated and the prevalence was neoplasms (53%). The canine specie was the most observed, with 92% of cases. Females totaled 53%. The age ranged from one to 17 years and the interval of six to 10 years was most observed (40% of cases). The round cell neoplasms were the most prevalent, followed by breast neoformations.Faculdade de Ciências Agrárias e Veterinárias FCAV-Unesp, Jaboticabal, SPFaculdade de Medicina Veterinária e Zootecnia - FMVZ-USP, São Paulo, SPUniversidade Estadual de Maringá, Maringá, PRFaculdade Integrado de Campo Mourão, Campo Mourão, PRFaculdade de Ciências Agrárias e Veterinárias FCAV-Unesp, Jaboticabal, S

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis

Вивчення механізмів накопичення пошкоджень в армованих композитах алюміній-бор-сталь при термоциклюванні

The internal friction method has been used to study the damage accumulation under thermal cycling of an aluminum-boron-steel composite material produced by hot pressing technique. The steel has been introduced into the material in the form of knitted nets containing different amounts of wires in the bundle. The main mechanism of damage accumulation in the material has been shown to be of binding break-off nature at the aluminum-steel interfaces.Методом внутреннего трения изучается природа накопления повреждений при тер-моциклировании композиционного материала алюминий-бор-сталь, изготовленного методом горячего прессования. Сталь входит в материал в виде трикотажной сетки с различным содержанием проволок в жгуте. Показано, что основным механизмом накопления повреждений в таком композите является нарушение связи на границе алюминий-сталь.Методом внутрішнього тертя вивчається природа накопичення пошкоджень при термоциклюванні композиційного матеріалу алюміній-бор-сталь, виготовленого способом гарячого пресування. Сталь входить в матеріал у вигляді трикотажної сітки з різним вмістом дротиків у джгуті. Показано, що основним механізмом накопичення пошкоджень в цьому композиті є порушення зв’язку на межі алюміній-сталь

Metástase de seminoma em região orbital em cão - relato de caso

RESUMO O seminoma é uma neoformação testicular originária de células germinativas de ocorrência comum em cães, com maior prevalência em animais senis. Em geral, o comportamento biológico do seminoma canino é benigno. Relata-se neste trabalho um caso de seminoma com metástase em região orbital em um cão com 14 anos de idade. O animal foi atendido com queixa de aumento de volume em órbita esquerda, com posterior detecção de nódulo testicular. A punção aspirativa por agulha fina da massa orbital sugeriu tratar-se de linfoma de alto grau, contudo o diagnóstico definitivo de seminoma difuso foi estabelecido pela avaliação histopatológica, a qual revelou tratar-se de neoplasia maligna pouco diferenciada, sendo o diagnóstico de seminoma difuso confirmado pelo exame imunoistoquímico. Relatos de seminomas metastáticos em cães são incomuns. Objetivou-se com este trabalho relatar um caso de seminoma anaplásico difuso em cão cujo foco principal de metástase ocorreu em região orbital, além de descrever e discutir as dificuldades diagnósticas encontradas.</jats:p