FR1.3: Coping with Stressors along the Cassava Value Chain in Nigeria: Evidence to Strengthen Gender-Responsive Breeding and Inform Resilience

This study investigates gender perspectives on climate change (CC) and conflict stressors surrounding the cassava value-chain (VC) in Nigeria. Research Question(s): A State of Knowledge review identified the need to inquire into coping strategies and the preferred stressor-related cassava traits by specifically asking, "In what ways do gender roles and norms influence these". Methodology: Data elicited from 187 cassava farmers, 15 Key Informants and 63 VC Focus Group participants were analysed using descriptive and inferential statistics. Key findings: The study validates CC as a key factor in increased conflicts. Farmer-herder clashes, communal clashes and land disputes exacerbate the emergence of farm burning, theft and influence the kind of cassava food product made. This shapes stressor-related trait preferences like ‘early re-emergence of leaves after grazing', ‘short stem', ‘ratooning potential', and ‘stem-longevity' among men and women farmers and ‘multi-purpose suitability of roots' among processors/marketers mainly women. Coping mechanisms include relocating farms, migration and fragmented farming among men, and choice of food with less processing steps, backyard farming, forcing daughter's premature marriage and dependence on remittances from husbands among women. Resilience capacity is generally low, but men have a higher overall resilience capacity (t = 5.45) and level of access to assets (t = 6.698) which facilitate coping strategies like ‘relocating farms', migration and ‘fragmented farming'. Relevance and Implication of findings: Results present gendered coping strategies, corresponding stressor-related traits, as additional aspects important when evaluating the gender impact of breeding strategies concerning the positive benefits for, and possible harm to cassava users and especially women engaged in the cassava VC activities

Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for use by the human genetic community. Using a set of validation genotypes at SNP and bi-allelic indels we show that these haplotypes have lower genotype discordance and improved imputation performance into downstream GWAS samples, especially at low-frequency variants. © 2014 Macmillan Publishers Limited. All rights reserved

Role of Mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice

10.1371/journal.pone.0012220PLoS ONE58e1222

Comparison of dose-finding designs for narrow-therapeutic-index drugs: Concentration-controlled vs. dose-controlled trials

This study compared the performances of randomized dose-controlled trials (DCTs) with those of concentration-controlled trials (CCTs) in dose finding for drugs with narrow therapeutic indexes. A simulation-based study was performed for a hypothetical immunosuppressant agent with two clinical end points. Different scenarios were simulated and analyzed, and three designs were compared: one DCT and two CCTs (a target-equivalent CCT and a variability-equivalent CCT). The DCT was consistently superior to the CCTs in the following aspects: (i) precision and bias reduction in parameter estimates, (ii) precision and bias reduction in the estimate of optimal exposure, (iii) bias reduction in prediction of the estimated therapeutic benefit at estimated optimal exposure, and (iv) bias reduction in prediction of the estimated benefit of therapeutic drug monitoring as compared with fixed dosing. DCT designs are more informative when describing the exposure-response relationship for drugs with narrow therapeutic indexes and provide a better basis for decision making with regard to dosing strategy

A bromocriptine-responsive corticotroph adenoma secreting α-MSH in a patient with Cushing's disease

Clinical and in-vitro investigations have been performed on a corticotroph adenoma removed from a patient suffering from Cushing's disease. Prior to surgery, the patient's Cushing's disease had been successfully controlled, clinically and biochemically, by long term administration of bromocriptine. After selective adenomectomy, tumour tissue was investigated by a perfused isolated cell column technique. It was shown that the tumour cells secreted immunoreactive- (IR)- ACTH and IR-alpha-MSH and that the release of both peptides was promptly suppressed by dopamine. Chromatographic analysis of the secreted IR-alpha-MSH revealed a high proportion of acetylated alpha-MSH; smaller amounts of desacetyl alpha-MSH and diacetyl alpha-MSH were present. The relevance of these findings to the proposal that certain corticotroph adenomas are derived from the intermediate lobe of the pituitary is discussed. It is concluded that there is little direct evidence for involvement of the residual zona intermedia of the adult human pituitary in the development of Cushing's disease

Nonlinear Dynamics of Magnetic Bearing Systems

Copyright © 2008 by SAGE PublicationsMagnetic bearings use magnetic forces to support various machine components. Because of the non-contact nature of this type of suspension, magnetic bearing technology offers a number of significant advantages over conventional bearings, such as rolling element and fluid film bearings. An active magnetic bearing basically consists of an electromagnetic actuator, position sensors, power amplifiers, and a feedback controller. All of these components are characterized by nonlinear behavior and therefore the entire system is inherently nonlinear. However, in simulations of the dynamic behavior of magnetic bearing systems, the nonlinearities are usually neglected to simplify the analysis and only linear models are used. Moreover, many control techniques currently used in magnetic bearing systems are generally designed by ignoring nonlinear effects. The main reason for simplification is the intractability of the complexity of the actual model. In fact, the inherent nonlinear properties of magnetic bearing systems can lead to dynamic behavior of a magnetically suspended rotor that is distinctly different from that predicted using a simple linearized model. Therefore, the nonlinearities should be taken into account. This literature review is focused on the nonlinear dynamics of magnetic bearing systems and it provides background information on analytical methods, nonlinear vibrations resulting from a rotor contacting auxiliary bearings, and other active topics of research involving the nonlinear properties of magnetic bearing systems, such as nonlinear self-sensing magnetic bearings and nonlinear control of magnetic bearings. The review concludes with a brief discussion on current and possible future directions for research on the nonlinear dynamics of magnetic bearing systems.J.C. Ji, Colin H. Hansen and Anthony C. Zande