75 research outputs found
Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)
BACKGROUND:
Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control.
METHODS:
Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights.
FINDINGS:
5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease.
INTERPRETATION:
International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems
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Arctic Sea Ice Loss, Long-Term Trends in Extratropical Wave Forcing, and the Observed Strengthening of the QBO-MJO Connection
A modulation has been identified of the tropical Madden-Julian oscillation (MJO) by the stratospheric quasi-biennial oscillation (QBO) such that the MJO in boreal winter is ∼40% stronger and persists ∼10 days longer during the easterly QBO phase (QBOE) than during the westerly phase. A proposed mechanism is reductions of tropical lower stratospheric static stability during QBOE caused by (a) the QBO induced meridional circulation; and (b) QBO influences on extratropical wave forcing of the stratospheric residual meridional circulation during early winter. Here, long-term variability of the QBO-MJO connection and associated variability of near-tropopause tropical static stability and extratropical wave forcing are investigated using European Center reanalysis data for the 1959–2021 period. During the most reliable (post-satellite) part of the record beginning in 1979, a strengthening of the QBO-MJO modulation has occurred during a time when tropical static stability in the lowermost stratosphere and uppermost troposphere has been decreasing and extratropical wave forcing in early winter has been increasing. A high inverse correlation (R = −0.87) is obtained during this period between early winter wave forcing anomalies and wintertime tropical lower stratospheric static stability. Regression relationships are used to show that positive trends in early winter wave forcing during this period have likely contributed to decreases in tropical static stability, favoring a stronger QBO-MJO connection. As shown in previous work, increased sea level pressure anomalies over northern Eurasia produced by Arctic sea ice loss may have been a significant source of the observed positive trends in early winter wave forcing. © 2023. American Geophysical Union. All Rights Reserved.6 month embargo; first published 17 December 2023This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Parallel modeling of the Apollinaris Patera magnetic and gravity anomalies
International audienc
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Lunar Magnetic Anomalies and Polar Ice
Solar wind ion sputtering is one of several non-negligible loss mechanisms for water ice in permanently shadowed regions (PSRs) near the lunar poles. Previous estimates of the solar wind ion flux within south polar PSRs have considered only the ambient solar wind flow and effects of topography. Here, improved maps of crustal magnetic fields in the lunar polar regions are constructed, confirming that more anomalies are present near the south pole than near the north pole. These anomalies have moderate amplitudes, occur over at least two permanently shadowed craters, and correlate approximately with the exposed water ice distribution. Because of the low angle of solar wind incidence near the poles, these anomalies are likely effective in reducing the ion flux, and any resulting water ice loss rate. These anomalies may therefore explain why more water ice is found near the south pole than near the north pole. © 2022. American Geophysical Union. All Rights Reserved.6 month embargo; first published: 07 November 2022This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
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