Muscles growing older: inflammatory markers and sex hormones as determinants of sarcopenia and decline in physical functioning

Deeg, D.J.H. [Promotor]Visser, M. [Promotor]Pluijm, S.M.F. [Copromotor

Особливості правового регулювання ліцензування господарської діяльності у сфері обігу дорогоцінного каміння

Здійснення господарської діяльності, на сьогодні, в нашій державі постійно трансформуються залежно від встановлених і закріплених в нормативно правових актах визначених і регульованих державою процедур, зокрема, шляхом ліцензування господарської діяльності, тому державна галузева політика у сфері діяльності суб’єктів господарювання, пов’язаної з дорогоцінними металами і дорогоцінним камінням має бути відрегульована належним чином не тільки через призму ліцензування, але й з урахуванням забезпечення балансу економіки та національної економічної безпеки країни. Ключові слова: ліцензування, ліцензія, господарська діяльність, процедура, нагляд, контроль, суб’єкти господарювання, дорогоцінні метали і каміння, використання дорогоцінних металів і дорогоцінного каміння.Осуществление хозяйственной деятельности, на сегодня, в нашем государстве постоянно трансформируются в зависимости от установленных и закрепленных в нормативно-правовых актах определенных и регулируемых государством процедур, в частности, путем лицензирования хозяйственной деятельности, поэтому государственная отраслевая политика в сфере деятельности субъектов ведения хозяйства, связанной с драгоценными металлами и драгоценными камнями должена быть отрегулирована должным образом не только через призму лицензирования, но и с учетом обеспечения баланса экономики и национальной экономической безопасности государства. Ключевые слова: лицензирование, лицензия, хозяйственная деятельность, процедура, контроль, субъекты ведения хозяйства, драгоценные металлы и камни, использование драгоценных металлов и драгоценных камней.Realization of enterprising movement, nowadays, in our state constantly transformed depending on position and envisaged in the normatively-legal acts of certain and managed by the state procedures, in particular, by licensing of enterprising, that is why public branch policy in the field of activity of enterprises, related to the precious metals and jewels must be adjusted properly not only through the prism of licensing but also taking into account providing of balance of economy and national economic security of a state. Key words: licensing, license, economic activity, procedure, supervision, control, enterprises, precious metals and stones, apply of precious metals and precious stones

Self-perceived weather sensitivity and joint pain in older people with osteoarthritis in six European countries: results from the European Project on Osteoarthritis (EPOSA)

Background: people with osteoarthritis (OA) frequently report that their joint pain is influenced by weather conditions. This study aimed to examine whether there are differences in perceived joint pain between older people with OA who reported to be weather-sensitive versus those who did not in six European countries with different climates and to identify characteristics of older persons with OA that are most predictive of perceived weather sensitivity.Methods: baseline data from the European Project on OSteoArthritis (EPOSA) were used. ACR classification criteria were used to determine OA. Participants with OA were asked about their perception of weather as influencing their pain. Using a two-week follow-up pain calendar, average self-reported joint pain was assessed (range: 0 (no pain)-10 (greatest pain intensity)). Linear regression analyses, logistic regression analyses and an independent t-test were used. Analyses were adjusted for several confounders.Results: the majority of participants with OA (67.2%) perceived the weather as affecting their pain. Weather-sensitive participants reported more pain than non-weather-sensitive participants (M?=?4.1, SD?=?2.4 versus M?=?3.1, SD?=?2.4; p?<?0.001). After adjusting for several confounding factors, the association between self-perceived weather sensitivity and joint pain remained present (B?=?0.37, p?=?0.03). Logistic regression analyses revealed that women and more anxious people were more likely to report weather sensitivity. Older people with OA from Southern Europe were more likely to indicate themselves as weather-sensitive persons than those from Northern Europe.Conclusions: weather (in)stability may have a greater impact on joint structures and pain perception in people from Southern Europe. The results emphasize the importance of considering weather sensitivity in daily life of older people with OA and may help to identify weather-sensitive older people with O

Genome analysis of Desulfotomaculum gibsoniae strain GrollT a highly versatile Gram-positive sulfate-reducing bacterium

Desulfotomaculum gibsoniae is a mesophilic member of the polyphyletic spore-forming genus Desulfotomaculum within the family Peptococcaceae. This bacterium was isolated from a freshwater ditch and is of interest because it can grow with a large variety of organic substrates, in particular several aromatic compounds, short-chain and medium-chain fatty acids, which are degraded completely to carbon dioxide coupled to the reduction of sulfate. It can grow autotrophically with H2 + CO2 and sulfate and slowly acetogenically with H2 + CO2, formate or methoxylated aromatic compounds in the absence of sulfate. For growth it does not require any vitamins. Here, we describe the features of D. gibsoniae strain GrollT together with the genome sequence and annotation. The chromosome has 4,855,529 bp organized in one circular contig and is the largest genome of all sequenced Desulfotomaculum spp., so far. A total of 4666 candidate protein-encoding genes and 96 RNA genes were identified. Genes of the acetyl-CoA pathway possibly involved in heterotrophic growth, and in CO2 fixation during autotrophic growth are present. The genome contains a large set of genes for the anaerobic transformation and degradation of aromatic compounds, which are lacking in the other sequenced Desulfotomaculum genomes

Factors associated with functional decline in hand and hip/knee osteoarthritis after one year: data from a population‐based study

Public Health and primary careGeriatrics in primary car

Onderzoek naar de mate van stuwpassage door graskarper in de Hagmolenbeek

Het bezwijken van een rooster dat ontsnappen van graskarper uit de Hagmolenbeek moest voorkómen, was aanleiding tot het uitvoeren van een onderzoek naar de mogelijkheid dat graskarper actief of passief stuwen passeert