The role of commercialization of high technologies in scientific and production cooperation

The article reveals the role and importance of types of high-tech products, taking into account international practice, domestic official statistics and classification of goods of foreign economic activity. It is established that in some cases innovative and high-tech products are identified. It is revealed that currently the most high-tech is the production of basic pharmaceutical products and pharmaceuticals, biotechnology, the production of computers, electronic and optical products; production of various air and space aircraft. The key regional leaders in the production of high-tech products in the world by region are considered. Based on the results of the consideration of the content of the concepts “innovation” and “technology”, “commercialization of innovations” and “commercialization of high-tech products”, the author’s vision of interpretations is proposed, with the justification that innovativeness actually acts as an additional feature of high-tech products. A study of the types of commercialization of high-tech products was conducted, according to the results of which the author’s classification was proposed according to the content, level of efficiency, number of subjects of commercialization, geographical coverage of subjects of commercialization and methods of financing

Innovative platform for economic transformation agricultural sector of the Russian economy

The situation has developed in such a way that the development of any country in the world is impossible without the introduction of new technologies. However, a simple technological upgrade of individual enterprises or even industries may not create an economic system specializing specifically in innovation. Such a system should be based on institutional provisions that would encourage economic entities to reproduce their activities on the basis of modern technologies and innovations. As practice shows, in agriculture, the innovative way is the only possible one in modern conditions. This trend is primarily due to the fact that land resources are not unlimited, and labor is declining from year to year. Therefore, further growth in production volumes is possible only on the path of innovation and investment development. It is proved that the policy of territorial innovation clusters, the implementation of which contributes to the strengthening of positive institutional effects on an innovative basis, affects the harmonious innovative development of agricultural enterprises

The russian agricultural sector in the innovative component of the country’s food security

Achieving competitiveness in the global world economy system requires strengthening the innovative direction of representatives of the domestic agro-industrial sector. The innovative component of the agricultural sector also plays an important role in solving the country’s food security. The article considers the basics of the development of innovative activity of agro-industrial enterprises and the impact of innovative activity in the agro-industrial complex on the country food security. Obstacles are analyzed and priority directions of innovative development of agro-industrial enterprises are reflected

Features of intensive production in the development of agriculture: The innovative aspect

In the article, the authors reveal the organizational and economic mechanism of innovation-intensive development of agricultural enterprises, which is based on a comprehensive system of scientific, technical, economic, technological research and development and depends on organizational, legal, economic, legal and technical levers to increase the efficiency of activities. The component of scientific support for innovation-intensive development, methods and directions of its implementation in agricultural production are identified and justified. It is proved that the determining role in modern conditions for the formation of an innovation-intensive type of development is played by a set of factors that are conditionally divided into external and internal, organizational and managerial, scientific and technical, technological, informational, etc. According to the results of the research, the spheres of application of scientific developments are proposed and the directions of their implementation on the way to the transition to an innovation-intensive type of production in agriculture are highlighted

“Green” technologies at the heart of sustainable development of the economy of russia and the world

The article examines the essence of the “green” economy, identifies its three components - economic, social, environmental, and justifies the need for the green economy development in Russia. It is argued that the environmental component is a priority for sustainable development. Among the main directions of the “green” economy implementation in Russia, the following is highlighted: rational use of natural resource potential, diversification of energy supply sources, environmental protection, production of organic agricultural products, modernization of housing and communal services, formation of new ecological behavior of the population

APPLICATION OF ANTITHYMOCYTE GLOBULIN IN CHILDREN AFTER CADAVER KIDNEY TRANSPLANTATION. RETROSPECTIVE ANALYSIS

The article provides results of in-house research to assess the impact of induction immunosuppression using antithymocyte globulin (ATG) on the clinical course of post-transplantation period after kidney transplantation. The authors analysed 260 allotransplantations of cadaver kidneys (215 children). In some children (n = 25) the medicine was used for induction therapy, in some (n = 10) to suppress steroid-resistant rejection. Patients in the control group (n = 189) were not administered ATG. The highest actuarial survival rate (both transplants and patients) was recorded in the group of children where ATG was used for induction therapy, rather than just for treatment of rejection.Key words: induction therapy, allotransplantation of kidney, antithymocyte globulin, survival rate, children

APPLICATION OF ANTITHYMOCYTE GLOBULIN IN CHILDREN AFTER CADAVER KIDNEY TRANSPLANTATION. RETROSPECTIVE ANALYSIS

The article provides results of in-house research to assess the impact of induction immunosuppression using antithymocyte globulin (ATG) on the clinical course of post-transplantation period after kidney transplantation. The authors analysed 260 allotransplantations of cadaver kidneys (215 children). In some children (n = 25) the medicine was used for induction therapy, in some (n = 10) to suppress steroid-resistant rejection. Patients in the control group (n = 189) were not administered ATG. The highest actuarial survival rate (both transplants and patients) was recorded in the group of children where ATG was used for induction therapy, rather than just for treatment of rejection.Key words: induction therapy, allotransplantation of kidney, antithymocyte globulin, survival rate, children

ПРИМЕНЕНИЕ АНТИТИМОЦИТАРНОГО ГЛОБУЛИНА У ДЕТЕЙ ПРИ АЛЛОТРАНСПЛАНТАЦИИ ПОЧЕК. РЕТРОСПЕКТИВНЫЙ АНАЛИЗ

The article provides results of in-house research to assess the impact of induction immunosuppression using antithymocyte globulin (ATG) on the clinical course of post-transplantation period after kidney transplantation. The authors analysed 260 allotransplantations of cadaver kidneys (215 children). In some children (n = 25) the medicine was used for induction therapy, in some (n = 10) to suppress steroid-resistant rejection. Patients in the control group (n = 189) were not administered ATG. The highest actuarial survival rate (both transplants and patients) was recorded in the group of children where ATG was used for induction therapy, rather than just for treatment of rejection.Key words: induction therapy, allotransplantation of kidney, antithymocyte globulin, survival rate, children.В статье приводятся результаты собственного исследования по оценке влияния индукционной иммуносупрессии с помощью антитимоцитарного глобулина (АТГ) на течение посттрансплантационного периода после пересадки почки. Авторы проанализировали 260 аллотрансплантаций трупных почек у 215 детей (части детей проводилась повторная трансплантация почки). У части детей (n = 25) АТГ применяли для индукционной терапии, у части (n = 10) — с целью подавления стероидрезистентного отторжения. Пациентам контрольной группы (n = 180) АТГ не назначали. Наиболее высокая актуарная выживаемость (как трансплантатов, так и пациентов) была в группе детей, в которой АТГ применяли для индукционной терапии, а не только лечения реакции отторжения. Ключевые слова: индукционная терапия, аллотрансплантация почки, антитимоцитарный глобулин, выживаемость, дети.(Педиатрическая фармакология 2011;8(1):46-50

Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo

Background: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagonlike peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated. Methods: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallelgroup, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy. Results: Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m2, and duration of T2DM was 9.3±8.2 years. The qualifying ACS wasamyocardial infarctionin83% and unstableangina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events. Conclusion: ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk. © 2015 Elsevier Inc. All rights reserved