24,956 research outputs found
A multiplexed single electron transistor for application in scalable solid-state quantum computing
Single Electron Transistors (SETs) are nanoscale electrometers of
unprecedented sensitivity, and as such have been proposed as read-out devices
in a number of quantum computer architectures. We show that the functionality
of a standard SET can be multiplexed so as to operate as both read-out device
and control gate for a solid-state qubit. Multiplexing in this way may be
critical in lowering overall gate densities in scalable quantum computer
architectures.Comment: 3 pages 3 figure
Chemical modification of poly(p-phenylene) for use in ablative compositions
Development of ablative materials based on modification of polyphenylene compounds is discussed. Chemical and physical properties are analyzed for application as heat resistant materials. Synthesis of linear polyphenylenes is described. Effects of exposure to oxyacetylene flame and composition of resultant char layer are presented
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Microbiomes Reduce Their Host's Sensitivity to Interspecific Interactions.
Bacteria associated with eukaryotic hosts can affect host fitness and trophic interactions between eukaryotes, but the extent to which bacteria influence the eukaryotic species interactions within trophic levels that modulate biodiversity and species coexistence is mostly unknown. Here, we used phytoplankton, which are a classic model for evaluating interactions between species, grown with and without associated bacteria to test whether the bacteria alter the strength and type of species interactions within a trophic level. We demonstrate that host-associated bacteria alter host growth rates and carrying capacity. This did not change the type but frequently changed the strength of host interspecific interactions by facilitating host growth in the presence of an established species. These findings indicate that microbiomes can regulate their host species' interspecific interactions. As between-species interaction strength impacts their ability to coexist, our findings show that microbiomes have the potential to modulate eukaryotic species diversity and community composition.IMPORTANCE Description of the Earth's microbiota has recently undergone a phenomenal expansion that has challenged basic assumptions in many areas of biology, including hominid evolution, human gastrointestinal and neurodevelopmental disorders, and plant adaptation to climate change. By using the classic model system of freshwater phytoplankton that has been drawn upon for numerous foundational theories in ecology, we show that microbiomes, by facilitating their host population, can also influence between-species interactions among their eukaryotic hosts. Between-species interactions, including competition for resources, has been a central tenet in the field of ecology because of its implications for the diversity and composition of communities and how this in turn shapes ecosystem functioning
Perspectives of healthcare providers on the nutritional management of patients on haemodialysis in Australia: An interview study
Objective To describe the perspectives of healthcare providers on the nutritional management of patients on haemodialysis, which may inform strategies for improving patient-centred nutritional care. Design Face-to-face semistructured interviews were conducted until data saturation, and thematic analysis based on principles of grounded theory. Setting 21 haemodialysis centres across Australia. Participants 42 haemodialysis clinicians (nephrologists and nephrology trainees (15), nurses (12) and dietitians (15)) were purposively sampled to obtain a range of demographic characteristics and clinical experiences. Results Six themes were identified: responding to changing clinical status (individualising strategies to patient needs, prioritising acute events, adapting guidelines), integrating patient circumstances (assimilating life priorities, access and affordability), delineating specialty roles in collaborative structures (shared and cohesive care, pivotal role of dietary expertise, facilitating access to nutritional care, perpetuating conflicting advice and patient confusion, devaluing nutritional specialty), empowerment for behaviour change (enabling comprehension of complexities, building autonomy and ownership, developing self-efficacy through engagement, tailoring self-management strategies), initiating and sustaining motivation (encountering motivational hurdles, empathy for confronting life changes, fostering non-judgemental relationships, emphasising symptomatic and tangible benefits, harnessing support networks), and organisational and staffing barriers (staffing shortfalls, readdressing system inefficiencies). Conclusions Organisational support with collaborative multidisciplinary teams and individualised patient care were seen as necessary for developing positive patient-clinician relationships, delivering consistent nutrition advice, and building and sustaining patient motivation to enable change in dietary behaviour. Improving service delivery and developing and delivering targeted, multifaceted self-management interventions may enhance current nutritional management of patients on haemodialysis
Analysis and Geometric Optimization of Single Electron Transistors for Read-Out in Solid-State Quantum Computing
The single electron transistor (SET) offers unparalled opportunities as a
nano-scale electrometer, capable of measuring sub-electron charge variations.
SETs have been proposed for read-out schema in solid-state quantum computing
where quantum information processing outcomes depend on the location of a
single electron on nearby quantum dots. In this paper we investigate various
geometries of a SET in order to maximize the device's sensitivity to charge
transfer between quantum dots. Through the use of finite element modeling we
model the materials and geometries of an Al/Al2O3 SET measuring the state of
quantum dots in the Si substrate beneath. The investigation is motivated by the
quest to build a scalable quantum computer, though the methodology used is
primarily that of circuit theory. As such we provide useful techniques for any
electronic device operating at the classical/quantum interface.Comment: 13 pages, 17 figure
The type of adjuvant in whole inactivated influenza a virus vaccines impacts vaccine-associated enhanced respiratory disease
Influenza A virus (IAV) causes a disease burden in the swine industry in the US and is a challenge to prevent due to substantial genetic and antigenic diversity of IAV that circulate in pig populations. Whole inactivated virus (WIV) vaccines formulated with oil-in-water (OW) adjuvant are commonly used in swine. However, WIV-OW are associated with vaccine-associated enhanced respiratory disease (VAERD) when the hemagglutinin and neuraminidase of the vaccine strain are mismatched with the challenge virus. Here, we assessed if different types of adjuvant in WIV vaccine formulations impacted VAERD outcome. WIV vaccines with a swine δ1-H1N2 were formulated with different commercial adjuvants: OW1, OW2, nano-emulsion squalene-based (NE) and gel polymer (GP). Pigs were vaccinated twice by the intramuscular route, 3 weeks apart, then challenged with an H1N1pdm09 three weeks post-boost and necropsied at 5 days post infection. All WIV vaccines elicited antibodies detected using the hemagglutination inhibition (HI) assay against the homologous vaccine virus, but not against the heterologous challenge virus; in contrast, all vaccinated groups had cross-reactive IgG antibody and IFN-γ responses against H1N1pdm09, with a higher magnitude observed in OW groups. Both OW groups demonstrated robust homologous HI titers and cross-reactivity against heterologous H1 viruses in the same genetic lineage. However, both OW groups had severe immunopathology consistent with VAERD after challenge when compared to NE, GP, and non-vaccinated challenge controls. None of the WIV formulations protected pigs from heterologous virus replication in the lungs or nasal cavity. Thus, although the type of adjuvant in the WIV formulation played a significant role in the magnitude of immune response to homologous and antigenically similar H1, none tested here increased the breadth of protection against the antigenically-distinct challenge virus, and some impacted immunopathology after challenge
Off-equilibrium dynamics of the two-dimensional Coulomb glass
The dynamics of the 2D Coulomb glass model is investigated by kinetic Monte
Carlo simulation. An exponential divergence of the relaxation time signals a
zero-temperature freezing transition. At low temperatures the dynamics of the
system is glassy. The local charge correlations and the response to
perturbations of the local potential show aging. The dynamics of formation of
the Coulomb gap is slow and the density of states at the Fermi level decays in
time as a power law. The relevance of these findings for recent transport
experiments in Anderson-insulating films is pointed out.Comment: 7 pages, 7 figure
Point-wise mutual information-based video segmentation with high temporal consistency
In this paper, we tackle the problem of temporally consistent boundary
detection and hierarchical segmentation in videos. While finding the best
high-level reasoning of region assignments in videos is the focus of much
recent research, temporal consistency in boundary detection has so far only
rarely been tackled. We argue that temporally consistent boundaries are a key
component to temporally consistent region assignment. The proposed method is
based on the point-wise mutual information (PMI) of spatio-temporal voxels.
Temporal consistency is established by an evaluation of PMI-based point
affinities in the spectral domain over space and time. Thus, the proposed
method is independent of any optical flow computation or previously learned
motion models. The proposed low-level video segmentation method outperforms the
learning-based state of the art in terms of standard region metrics
eHealth interventions for people with chronic kidney disease
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: This review aims to look at the benefits and harms of using eHealth interventions in the CKD population
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