5 research outputs found
Dynamical and stationary critical behavior of the Ising ferromagnet in a thermal gradient
In this paper we present and discuss results of Monte Carlo numerical
simulations of the two-dimensional Ising ferromagnet in contact with a heat
bath that intrinsically has a thermal gradient. The extremes of the magnet are
at temperatures , where is the Onsager critical temperature.
In this way one can observe a phase transition between an ordered phase
() by means of a single simulation. By
starting the simulations with fully disordered initial configurations with
magnetization corresponding to , which are then suddenly
annealed to a preset thermal gradient, we study the short-time critical dynamic
behavior of the system. Also, by setting a small initial magnetization ,
we study the critical initial increase of the order parameter. Furthermore, by
starting the simulations from fully ordered configurations, which correspond to
the ground state at T=0 and are subsequently quenched to a preset gradient, we
study the critical relaxation dynamics of the system. Additionally, we perform
stationary measurements () that are discussed in terms of
the standard finite-size scaling theory. We conclude that our numerical
simulation results of the Ising magnet in a thermal gradient, which are
rationalized in terms of both dynamic and standard scaling arguments, are fully
consistent with well established results obtained under equilibrium conditions
Efficient Parallel Multi‐Bit Logic‐in‐Memory Based on a Ultrafast Ferroelectric Tunnel Junction Memristor
X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.
BACKGROUND & AIMS: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. METHODS: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). RESULTS: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10(-4), with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10(-6); odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10(-8)), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10(-9); OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). CONCLUSIONS: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.The article is available via Open Access. Click on the 'Additional link' above to access the full-text.Published version, accepted versio