16 x 25 Ge:Ga Detector Arrays for FIFI LS

We are developing two-dimensional 16 x 25 pixel detector arrays of both unstressed and stressed Ge:Ga photoconductive detectors for far-infrared astronomy from SOFIA. The arrays, based on earlier 5 x 5 detector arrays used on the KAO, will be for our new instrument, the Far Infrared Field Imaging Line Spectrometer (FIFI LS). The unstressed Ge:Ga detector array will cover the wavelength range from 40 to 120 microns, and the stressed Ge:Ga detector array from 120 to 210 microns. The detector arrays will be operated with multiplexed integrating amplifiers with cryogenic readout electronics located close to the detector arrays. The design of the stressed detector array and results of current measurements on several prototype 16 pixel linear arrays are reported. They demonstrate the feasibility of the current concept. ***This paper does not include Figures due to astro-ph size limitations. Please download entire file at http://fifi-ls.mpe-garching.mpg.de/spie.det.ps.gz ***Comment: 8 pages, SPIE Proceedings, Astronomical Telescopes and Instrumentation 200

Testing Magnetic Field Models for the Class 0 Protostar L1527

For the Class 0 protostar, L1527, we compare 131 polarization vectors from SCUPOL/JCMT, SHARP/CSO and TADPOL/CARMA observations with the corresponding model polarization vectors of four ideal-MHD, non-turbulent, cloud core collapse models. These four models differ by their initial magnetic fields before collapse; two initially have aligned fields (strong and weak) and two initially have orthogonal fields (strong and weak) with respect to the rotation axis of the L1527 core. Only the initial weak orthogonal field model produces the observed circumstellar disk within L1527. This is a characteristic of nearly all ideal-MHD, non-turbulent, core collapse models. In this paper we test whether this weak orthogonal model also has the best agreement between its magnetic field structure and that inferred from the polarimetry observations of L1527. We found that this is not the case; based on the polarimetry observations the most favored model of the four is the weak aligned model. However, this model does not produce a circumstellar disk, so our result implies that a non-turbulent, ideal-MHD global collapse model probably does not represent the core collapse that has occurred in L1527. Our study also illustrates the importance of using polarization vectors covering a large area of a cloud core to determine the initial magnetic field orientation before collapse; the inner core magnetic field structure can be highly altered by a collapse and so measurements from this region alone can give unreliable estimates of the initial field configuration before collapse.Comment: 43 pages, 9 figures, 4 tables. Accepted by the Astrophysical Journa

1.3 mm Polarized emission in the circumstellar disk of a massive protostar

We present the first resolved observations of the 1.3 mm polarized emission from the disk-like structure surrounding the high-mass protostar Cepheus A HW2. These CARMA data partially resolve the dust polarization, suggesting a uniform morphology of polarization vectors with an average position angle of 57° ± 6° and an average polarization fraction of 2.0% ± 0.4%. The distribution of the polarization vectors can be attributed to (1) the direct emission of magnetically aligned grains of dust by a uniform magnetic field, or (2) the pattern produced by the scattering of an inclined disk. We show that both models can explain the observations, and perhaps a combination of the two mechanisms produces the polarized emission. A third model including a toroidal magnetic field does not match the observations. Assuming scattering is the polarization mechanism, these observations suggest that during the first few 104 years of high-mass star formation, grain sizes can grow from1 mm to several 10s μm.Fil: Fernandez Lopez, Manuel. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomia; ArgentinaFil: Stephens, I. W.. Harvard-Smithsonian Center for Astrophysics; Estados Unidos. Boston University; Estados Unidos. University of Illinois; Estados UnidosFil: Girart, J. M.. Harvard-Smithsonian Center for Astrophysics; Estados Unidos. Institut de Ciències de l’Espai; EspañaFil: Looney, L.. University of Illinois; Estados UnidosFil: Curiel, S.. Universidad Nacional Autónoma de México; MéxicoFil: Segura Cox, D.. University of Illinois; Estados UnidosFil: Eswaraiah, C.. National Tsing Hua University; República de ChinaFil: Lai, S. P.. National Tsing Hua University; República de Chin

Tumour-associated macrophages and oncolytic virotherapies:a mathematical investigation into a complex dynamics

Anti-cancer therapies based on oncolytic viruses are emerging as important approaches in cancer treatment. However, the effectiveness of these therapies depends significantly on the interactions between the oncolytic viruses and the host immune response. Macrophages are one of the most important cell types in the anti-viral immune responses, by acting as a first line of defence against infections. Here, we consider a mathematical approach to investigate the possible outcomes of the interactions between two extreme phenotypes of macrophages (M1 and M2 cells) and an oncolytic virus (VSV), in the context of B16F10 melanoma. We show that polarization towards either an M1 or M2 phenotype can enhance oncolytic virus therapy through either (i) anti-tumour immune activation, or (ii) enhanced oncolysis. Moreover, we show that tumour reduction and elimination does not depend only on the ratio of M1:M2 cells, but also on the number of tumour-infiltrating macrophages

A Sub-arcsecond Survey Toward Class 0 Protostars in Perseus: Searching for Signatures of Protostellar Disks

We present a CARMA 1.3 mm continuum survey toward 9 Class 0 protostars in the Perseus molecular cloud at $\sim$0.3$^{\prime\prime}$ (70 AU) resolution. This study approximately doubles the number of Class 0 protostars observed with spatial resolutions $<$ 100 AU at millimeter wavelengths, enabling the presence of protostellar disks and proto-binary systems to be probed. We detect flattened structures with radii $>$ 100 AU around 2 sources (L1448 IRS2 and Per-emb-14) and these sources may be strong disk candidates. Marginally-resolved structures with position angles within 30$^{\circ}$ of perpendicular to the outflow are found toward 3 protostars (L1448 IRS3C, IRAS 03282+3035, and L1448C) and are considered disk candidates. Two others (L1448 IRS3B and IRAS 03292+3039) have resolved structure, possibly indicative of massive inner envelopes or disks; L1448 IRS3B also has a companion separated by 0.9$^{\prime\prime}$ ($\sim$210 AU). IC348-MMS does not have well-resolved structure and the candidate first hydrostatic core L1451-MMS is marginally resolved on 1$^{\prime\prime}$ scales. The strong disk candidate sources were followed-up with C$^{18}$O ($J=2\rightarrow1$) observations, detecting velocity gradients consistent with rotation, but it is unclear if the rotation is Keplerian. We compare the observed visibility amplitudes to radiative transfer models, finding that visibility amplitude ratios suggest a compact component (possibly a disk) is necessary for 5 of 9 Class 0 sources; envelopes alone may explain the other 4 systems. We conclude that there is evidence for the formation of large disks in the Class 0 phase with a range of radii and masses dependent upon their initial formation conditions.Comment: Accepted to ApJ, 58 pages, 19 Figures, 5 Table

Radioactive Probes of the Supernova-Contaminated Solar Nebula: Evidence that the Sun was Born in a Cluster

We construct a simple model for radioisotopic enrichment of the protosolar nebula by injection from a nearby supernova, based on the inverse square law for ejecta dispersion. We find that the presolar radioisotopes abundances (i.e., in solar masses) demand a nearby supernova: its distance can be no larger than 66 times the size of the protosolar nebula, at a 90% confidence level, assuming 1 solar mass of protosolar material. The relevant size of the nebula depends on its state of evolution at the time of radioactivity injection. In one scenario, a collection of low-mass stars, including our sun, formed in a group or cluster with an intermediate- to high-mass star that ended its life as a supernova while our sun was still a protostar, a starless core, or perhaps a diffuse cloud. Using recent observations of protostars to estimate the size of the protosolar nebula constrains the distance of the supernova at 0.02 to 1.6 pc. The supernova distance limit is consistent with the scales of low-mass stars formation around one or more massive stars, but it is closer than expected were the sun formed in an isolated, solitary state. Consequently, if any presolar radioactivities originated via supernova injection, we must conclude that our sun was a member of such a group or cluster that has since dispersed, and thus that solar system formation should be understood in this context. In addition, we show that the timescale from explosion to the creation of small bodies was on the order of 1.8 Myr (formal 90% confidence range of 0 to 2.2 Myr), and thus the temporal choreography from supernova ejecta to meteorites is important. Finally, we can not distinguish between progenitor masses from 15 to 25 solar masses in the nucleosynthesis models; however, the 20 solar mass model is somewhat preferred.Comment: ApJ accepted, 19 pages, 3 figure