378 research outputs found
Single-vortex-induced voltage steps in Josephson-junction arrays
We have numerically and analytically studied ac+dc driven Josephson-junction
arrays with a single vortex or with a single vortex-antivortex pair present. We
find single-vortex steps in the voltage versus current characteristics (I-V) of
the array. They correspond microscopically to a single vortex phase-locked to
move a fixed number of plaquettes per period of the ac driving current. In
underdamped arrays we find vortex motion period doubling on the steps. We
observe subharmonic steps in both underdamped and overdamped arrays. We
successfully compare these results with a phenomenological model of vortex
motion with a nonlinear viscosity. The I-V of an array with a vortex-antivortex
pair displays fractional voltage steps. A possible connection of these results
to present day experiments is also discussed.Comment: 10 pages double sided with figures included in the text. To appear in
Journal of Physics, Condensed Matte
Dynamic Impedance of Two-Dimensional Superconducting Films Near the Superconducting Transition
The sheet impedances, Z(w,T), of several superconducting a-Mo77Ge23 films and
one In/InOx film have been measured in zero field using a two-coil mutual
inductance technique at frequencies from 100 Hz to 100 kHz. Z(w,T) is found to
have three contributions: the inductive superfluid, renormalized by nonvortex
phase fluctuations; conventional vortex-antivortex pairs, whose contribution
turns on very rapidly just below the usual Kosterlitz-Thouless-Berezinskii
unbinding temperature; and an anomalous contribution. The latter is
predominantly resistive, persists well below the KTB temperature, and is weakly
dependent on frequency down to remarkably low frequencies, at least 100 Hz. It
increases with T as e-U'(T)/kT, where the activation energy, U'(T), is about
half the energy to create a vortex-antivortex pair, indicating that the
frequency dependence is that of individual excitations, rather than critical
behavior.Comment: 10 pages, 10 figs; subm PR
The impact of responding to patient messages with large language model assistance
Documentation burden is a major contributor to clinician burnout, which is
rising nationally and is an urgent threat to our ability to care for patients.
Artificial intelligence (AI) chatbots, such as ChatGPT, could reduce clinician
burden by assisting with documentation. Although many hospitals are actively
integrating such systems into electronic medical record systems, AI chatbots
utility and impact on clinical decision-making have not been studied for this
intended use. We are the first to examine the utility of large language models
in assisting clinicians draft responses to patient questions. In our two-stage
cross-sectional study, 6 oncologists responded to 100 realistic synthetic
cancer patient scenarios and portal messages developed to reflect common
medical situations, first manually, then with AI assistance.
We find AI-assisted responses were longer, less readable, but provided
acceptable drafts without edits 58% of time. AI assistance improved efficiency
77% of time, with low harm risk (82% safe). However, 7.7% unedited AI responses
could severely harm. In 31% cases, physicians thought AI drafts were
human-written. AI assistance led to more patient education recommendations,
fewer clinical actions than manual responses. Results show promise for AI to
improve clinician efficiency and patient care through assisting documentation,
if used judiciously. Monitoring model outputs and human-AI interaction remains
crucial for safe implementation.Comment: 4 figures and tables in main, submitted for revie
Critical Exponents of the Fully Frustrated 2-D Xy Model
We present a detailed study of the critical properties of the 2-D XY model
with maximal frustration in a square lattice. We use extensive Monte Carlo
simulations to study the thermodynamics of the spin and chiral degrees of
freedom, concentrating on their correlation functions. The gauge invariant
spin-spin correlation functions are calculated close to the critical point for
lattice sizes up to ; the chiral correlation functions are
studied on lattices up to . We find that the critical exponents of
the spin phase transition are , and , which are to be
compared with the unfrustrated XY model exponents and . We
also find that the critical exponents of the chiral transition are
, , , and
, which are different from the expected 2-D Ising
critical exponents. The spin-phase transition occurs at which
is about 7\% above the estimated chiral critical temperature . However, because of the size of the statistical errors, it is
difficult to decide with certainty whether the transitions occur at the same or
at slightly different temperatures. Finally, the jump in the helicity modulus
in the fully frustrated system is found to be about 23\% below the unfrustrated
universal value. The most important consequence of these results is that the
fully frustrated XY model appears to be in a novel universality class. Recent
successful comparisons of some of these results with experimental data are also
briefly discussed. (TO APPEAR IN PRB)Comment: 47 pages (PHYZZX
Exercise therapy in adults with serious mental illness: a systematic review and meta-analysis
Background: Individuals with serious mental illness are at a higher risk of physical ill health. Mortality rates are at least twice those of the general population with higher levels of cardiovascular disease, metabolic disease, diabetes, and respiratory illness. Although genetics may have a role in the physical health problems of these patients, lifestyle and environmental factors such as levels of smoking, obesity, poor diet, and low levels of physical activity also play a prominent part.<p></p>
Objective: To conduct a systematic review and meta-analysis of randomised controlled trials comparing the effect of exercise interventions on individuals with serious mental illness.<p></p>
Methods: Searches were made in Ovid MEDLINE, Embase, CINAHL, PsycINFO, Biological Abstracts on Ovid, and The Cochrane Library (January 2009, repeated January 2013) through to February 2013.<p></p>
Results: Eight RCTs were identified in the systematic search. Six compared exercise versus usual care. One study assessed the effect of a cycling programme versus muscle strengthening and toning exercises. The final study compared the effect of adding specific exercise advice and motivational skills to a simple walking programme. Exercise programmes were noted by their heterogeneity in terms of the type of exercise intervention, setting, and outcome measures. The review found that exercise improved levels of exercise activity (n=13, standard mean difference [SMD] 1.81, CI 0.44 to 3.18, p = 0.01). No beneficial effect was found on negative (n = 84, SMD = -0.54, CI -1.79 to 0.71, p = 0.40) or positive symptoms of schizophrenia (n = 84, SMD = -1.66, CI -3.78 to 0.45, p = 0.12). No change was found on body mass index compared with usual care (n= 151, SMD = -0.24, CI -0.56 to 0.08, p = 0.14), or body weight (n = 77, SMD = 0.13, CI -0.32 to 0.58, p = 0.57).
No beneficial effect was found on anxiety and depressive symptoms (n = 94, SMD = -0.26, CI -0.91 to 0.39, p = 0.43), or quality of life in respect of physical and mental domains. One RCT measured the effect of exercise on exercise intensity, attendance, and persistence at a programme. No significant effect was found on these measures.<p></p>
Conclusions: This systematic review showed that exercise therapies can lead to a modest increase in levels of exercise activity but overall there was no noticeable change for symptoms of mental health, body mass index, and body weight.<p></p>
Colorectal Cancer Control Program Grantees’ Use of Evidence-Based Interventions
Colorectal cancer (CRC) screening is recommended for adults aged 50–75 years, yet screening rates are low, especially among the uninsured. The CDC initiated the Colorectal Cancer Control Program (CRCCP) in 2009 with the goal of increasing CRC screening rates to 80% by 2014. A total of 29 grantees (states and tribal organizations) receive CRCCP funding to (1) screen uninsured adults and (2) promote CRC screening at the population level
The relationship of punishment- and victim-based moral orientation to prosocial, externalizing, and norm trespassing behaviour in delinquent and non-delinquent adolescents:a validation study of the Moral Orientation Measure
This study examined the reliability and validity of the Moral Orientation Measure (MOM), which was administered to 75 juvenile delinquents and 579 non-delinquent adolescents from lower socio-economic and educational backgrounds. Confirmatory factor analysis of a two-factor model, with punishment- and victim-based moral orientation as factors, showed an adequate fit to the data, indicating construct validity of the MOM. Moderate associations between moral orientation and sociomoral reasoning, as well as empathy, were also considered indicative of construct validity. Additional evidence for construct validity was found in only small associations between moral orientation and social desirability and verbal intelligence. Stronger victim-based orientation proved to be associated with less norm trespassing behaviour in non-delinquent adolescents and more prosocial behaviour in juvenile delinquents, which was considered indicative of concurrent validity. The results of this study strengthen the case for the MOM as a reliable and valid instrument to assess moral development in adolescents at risk of behavioural maladjustment, showing that moral orientation is differently associated with morally relevant behaviour in delinquent and non-delinquent adolescents
Feedback and Reflection to Promote Student Participation in Computer Supported Collaborative Learning: A Multiple Case Study
Classification schemes for knowledge translation interventions: a practical resource for researchers
The Extracellular Domain of Myelin Oligodendrocyte Glycoprotein Elicits Atypical Experimental Autoimmune Encephalomyelitis in Rat and Species
Atypical models of experimental autoimmune encephalomyelitis (EAE) are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS). Conversely, models of classical EAE feature stereotypic progression of an ascending flaccid paralysis that is not a characteristic of MS. The study of atypical EAE however has been limited due to the relative lack of suitable models that feature reliable disease incidence and severity, excepting mice deficient in gamma-interferon signaling pathways. In this study, atypical EAE was induced in Lewis rats, and a related approach was effective for induction of an unusual neurologic syndrome in a cynomolgus macaque. Lewis rats were immunized with the rat immunoglobulin variable (IgV)-related extracellular domain of myelin oligodendrocyte glycoprotein (IgV-MOG) in complete Freund’s adjuvant (CFA) followed by one or more injections of rat IgV-MOG in incomplete Freund’s adjuvant (IFA). The resulting disease was marked by torticollis, unilateral rigid paralysis, forelimb weakness, and high titers of anti-MOG antibody against conformational epitopes of MOG, as well as other signs of atypical EAE. A similar strategy elicited a distinct atypical form of EAE in a cynomolgus macaque. By day 36 in the monkey, titers of IgG against conformational epitopes of extracellular MOG were evident, and on day 201, the macaque had an abrupt onset of an unusual form of EAE that included a pronounced arousal-dependent, transient myotonia. The disease persisted for 6–7 weeks and was marked by a gradual, consistent improvement and an eventual full recovery without recurrence. These data indicate that one or more boosters of IgV-MOG in IFA represent a key variable for induction of atypical or unusual forms of EAE in rat and Macaca species. These studies also reveal a close correlation between humoral immunity against conformational epitopes of MOG, extended confluent demyelinating plaques in spinal cord and brainstem, and atypical disease induction
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