2,609 research outputs found
New insight into the Pleistocene deposits of Monte delle Piche, Rome, and remarks on the biochronology of Hippopotamus (Mammalia, Hippopotamidae) and Stephanorhinus etruscus (Mammalia, Rhinocerotidae) in Italy
Several large mammal assemblages have been collected in the Roman basin since the XIX century, but they usually lack any stratigraphic datum or details about the fossiliferous localities. In this work, the stratigraphic provenance of large mammal remains discovered at Monte delle Piche (Rome) is investigated. The systematic revision of these specimens allows the recording of the presence of Hippopotamus sp., Stephanorhinus sp. and Stephanorhinus etruscus. On the basis of micropalaeontological analysis performed on sediment sampled from the studied specimens and considering the stratigraphy of the area, two fossiliferous levels are recognised at Monte delle Piche.
The remain of the hippopotamus was collected in fluvial gravels and sand deposits, in which the presence of Cyprideis is also recorded. This deposit is chronologically related to the latest Early-early Middle Pleistocene. Hippopotamus was present in Italy and Western Europe from the latest Villafranchian to MIS 4/3. The mandible of S. etruscus was collected in marine deposits along with abundant foraminifera and ostracods, which correlate with the late Early Pleistocene. Stephanorhinus etruscus occurred in Western Europe at the beginning of
the Villafranchian, and it was documented until the end of the Villafranchian in Italy and until the Early-Middle Pleistocene transition in the Iberian Peninsula
Facing Non-Stationary Conditions with a New Indicator of Entropy Increase: The Cassandra Algorithm
We address the problem of detecting non-stationary effects in time series (in
particular fractal time series) by means of the Diffusion Entropy Method (DEM).
This means that the experimental sequence under study, of size , is explored
with a window of size . The DEM makes a wise use of the statistical
information available and, consequently, in spite of the modest size of the
window used, does succeed in revealing local statistical properties, and it
shows how they change upon moving the windows along the experimental sequence.
The method is expected to work also to predict catastrophic events before their
occurrence.Comment: FRACTAL 2002 (Spain
Up-down biphasic volume response of human red blood cells to PIEZO1 activation during capillary transits.
In this paper we apply a novel JAVA version of a model on the homeostasis of human red blood cells (RBCs) to investigate the changes RBCs experience during single capillary transits. In the companion paper we apply a model extension to investigate the changes in RBC homeostasis over the approximately 200000 capillary transits during the ~120 days lifespan of the cells. These are topics inaccessible to direct experimentation but rendered mature for a computational modelling approach by the large body of recent and early experimental results which robustly constrain the range of parameter values and model outcomes, offering a unique opportunity for an in depth study of the mechanisms involved. Capillary transit times vary between 0.5 and 1.5s during which the red blood cells squeeze and deform in the capillary stream transiently opening stress-gated PIEZO1 channels allowing ion gradient dissipation and creating minuscule quantal changes in RBC ion contents and volume. Widely accepted views, based on the effects of experimental shear stress on human RBCs, suggested that quantal changes generated during capillary transits add up over time to develop the documented changes in RBC density and composition during their long circulatory lifespan, the quantal hypothesis. Applying the new red cell model (RCM) we investigated here the changes in homeostatic variables that may be expected during single capillary transits resulting from transient PIEZO1 channel activation. The predicted quantal volume changes were infinitesimal in magnitude, biphasic in nature, and essentially irreversible within inter-transit periods. A sub-second transient PIEZO1 activation triggered a sharp swelling peak followed by a much slower recovery period towards lower-than-baseline volumes. The peak response was caused by net CaCl2 and fluid gain via PIEZO1 channels driven by the steep electrochemical inward Ca2+ gradient. The ensuing dehydration followed a complex time-course with sequential, but partially overlapping contributions by KCl loss via Ca2+-activated Gardos channels, restorative Ca2+ extrusion by the plasma membrane calcium pump, and chloride efflux by the Jacobs-Steward mechanism. The change in relative cell volume predicted for single capillary transits was around 10-5, an infinitesimal volume change incompatible with a functional role in capillary flow. The biphasic response predicted by the RCM appears to conform to the quantal hypothesis, but whether its cumulative effects could account for the documented changes in density during RBC senescence required an investigation of the effects of myriad transits over the full four months circulatory lifespan of the cells, the subject of the next paper
Prospects for Stochastic Background Searches Using Virgo and LSC Interferometers
We consider the question of cross-correlation measurements using Virgo and
the LSC Interferometers (LIGO Livingston, LIGO Hanford, and GEO600) to search
for a stochastic gravitational-wave background. We find that inclusion of Virgo
into the network will substantially improve the sensitivity to correlations
above 200 Hz if all detectors are operating at their design sensitivity. This
is illustrated using a simulated isotropic stochastic background signal,
generated with an astrophysically-motivated spectrum, injected into 24 hours of
simulated noise for the LIGO and Virgo interferometers.Comment: 11 pages, uses IOP style files, submitted to CQG for GWDAW11
proceedings; revised in response to referee comment
Protein haze formation in wines revisited. The stabilising effect of organic acids
The effect on the wine protein haze potential of five organic acids commonly encountered in wines (L(+)-
tartaric, L( )-malic, citric, succinic and gluconic acids) was assessed. All five acids, tested at 20 mM,
reduced dramatically the haze potential of proteins, either in wine or dissolved in water, throughout
the range of pH values typical of wines (i.e., from 2.8 through 3.8). Subtle differences among the acid
effects did not correlate with the number of their carboxyl groups, but were attributed to electrostatic
interactions that depend upon the acid pKa values, the protein pI values and the medium pH. These
results invalidate or question the validity of all experiments on wine proteins involving wine model solutions
containing organic acids. Overall, the results obtained in the present work clearly indicate that
organic acids with a common occurrence in wines exhibit a stabilising effect upon the haze potential
of the wine proteins
Myringotomy and ventilation tube insertion with endoscopic or microscopic technique in adults: a pilot study
The purpose of this study is to assess the feasibility of endoscopic-assisted myringotomy and ventilation tube insertion in adults affected by chronic otitis media with effusion, comparing the outcomes of this approach with those obtained with the traditional microscopic technique. Twenty-four patients were enrolled in this trial and alternately assigned to 2 groups of 12 subjects each. In group A, patients underwent myringotomy and ventilation tube insertion under endoscopic view, whereas in group B, the same procedure was performed traditionally using a microscope. All cases were evaluated 1 week after surgery and then monthly until tube extrusion. Type A tympanogram was achieved in 10 of 13 ears in both groups (76.92%). No significant difference in operative times or complication rates was observed (P > .05). Endoscopic technique could be a viable alternative to the microscopic approach for myringotomy and ventilation tube positioning in adults affected by chronic otitis media with effusion
Compression and diffusion: a joint approach to detect complexity
The adoption of the Kolmogorov-Sinai (KS) entropy is becoming a popular
research tool among physicists, especially when applied to a dynamical system
fitting the conditions of validity of the Pesin theorem. The study of time
series that are a manifestation of system dynamics whose rules are either
unknown or too complex for a mathematical treatment, is still a challenge since
the KS entropy is not computable, in general, in that case. Here we present a
plan of action based on the joint action of two procedures, both related to the
KS entropy, but compatible with computer implementation through fast and
efficient programs. The former procedure, called Compression Algorithm
Sensitive To Regularity (CASToRe), establishes the amount of order by the
numerical evaluation of algorithmic compressibility. The latter, called Complex
Analysis of Sequences via Scaling AND Randomness Assessment (CASSANDRA),
establishes the complexity degree through the numerical evaluation of the
strength of an anomalous effect. This is the departure, of the diffusion
process generated by the observed fluctuations, from ordinary Brownian motion.
The CASSANDRA algorithm shares with CASToRe a connection with the Kolmogorov
complexity. This makes both algorithms especially suitable to study the
transition from dynamics to thermodynamics, and the case of non-stationary time
series as well. The benefit of the joint action of these two methods is proven
by the analysis of artificial sequences with the same main properties as the
real time series to which the joint use of these two methods will be applied in
future research work.Comment: 27 pages, 9 figure
Quantum point contact conductance in NINS junctions
The effect of an insulating barrier located at a distance from a NS
quantum point contact is analyzed in this work. The Bogoliubov de Gennes
equations are solved for NINS junctions (S: anysotropic superconductor, I:
insulator and N: normal metal), where the NIN region is a quantum wire. For , bound states and resonances in the differential conductance are
predicted. These resonances depend on the symmetry of the pair potential, the
strength of the insulating barrier and . Our results show that in a NINS
quantum point contact the number of resonances vary with the symmetry of the
order parameter. This is to be contrasted with the results for the NINS
junction, in which only the position of the resonances changes with the
symmetry.Comment: 5 pages, 5 Figures, RevTex
A constraint-relaxation-recovery mechanism for stomatal dynamics
Models of guard cell dynamics, built on the OnGuard platform, have provided quantitative insights into stomatal function, demonstrating substantial predictive power. However, the kinetics of stomatal opening predicted by OnGuard models were threefold to fivefold slower than observed in vivo. No manipulations of parameters within physiological ranges yielded model kinetics substantially closer to these data, thus highlighting a missing component in model construction. One wellâdocumented process influencing stomata is the constraining effect of the surrounding epidermal cells on guard cell volume and stomatal aperture. Here, we introduce a mechanism to describe this effect in OnGuard2 constructed around solute release and a decline in turgor of the surrounding cells and its subsequent recovery during stomatal opening. The results show that this constraintârelaxationârecovery mechanism in OnGuard2 yields dynamics that are consistent with experimental observations in wildâtype Arabidopsis, and it predicts the altered opening kinetics of ost2 H+âATPase and slac1 Clâ channel mutants. Thus, incorporating solute flux of the surrounding cells implicitly through their constraint on guard cell expansion provides a satisfactory representation of stomatal kinetics, and it predicts a substantial and dynamic role for solute flux across the apoplastic space between the guard cells and surrounding cells in accelerating stomatal kinetics
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