Transformations in socio-economic development of the Gulf group states

The article is devoted to the national economy transformations of the GCC States (Cooperation Council for the Arab States of the Gulf countries). This paper analyzes the dynamics of socio-economic development of the Gulf Group countries for the last 10 years, compares and systematizes the traditional and unique statistical data in order to prove the hypothesis that the positive dynamics was not only due to the high hydrocarbon prices on the global market but also to the successful structural transformation. The growth of the regional economy in the conditions of an almost threefold drop in world oil prices over the past three years is shown. We use systemic approach, comparative and statistical analysis. As the analysis of economic situation and development in the GCC countries at the current stage shows, all of them need to change the structure of the national economy and diversify it in order to reduce the dependence from mining industries, world prices fluctuations. This paper proposes a number of practical considerations and appropriate measures for the formation of more rational structure of the national economies, including the diversification of the sources of budget revenues through expanding industrialization; accelerating development of solid minerals and the creation of new industries using them. As Gulf States belong to the group of emerging countries and the structure of their national economies is similar with the Russian economy, the factors of the positive changes of the national economies will be useful for Russian and foreign researchers

NEW “GREEN” METHOD OF BROMINATION OF (–)-NOPINONE AND (+)-CIS-VERBANONE

This work was supported by the Integrated Program of Ural Branch of RAS (project № 18-3-3-17)

Comparative Analysis of Foreign Trade Development in the Digital Segment by World Regions

Foreign trade, affected by digitalisation, acquired new features, while its development led to a new redistribution of world regions. The present article aims to reveal specific features and emerging trends in the digital segment of foreign trade and identify leading regions and success factors. In this case, the digital segment includes ICT-equipment and ICT-services trade. UNCTAD statistics for 2000–2019 were examined using the methodology of foreign trade structural and comparative analysis. We hypothesise that there are different development stages in the digital segment of foreign trade characterised by changes of leading regions. In particular, three waves in the development of the digital segment of foreign trade, corresponding to different characteristics, were identified. In the third wave, the growth rate of digital turnover remained the same but its share in the total global turnover decreased. It was revealed that the share of the digital segment is higher than the share of merchandise trade in the countries of one region. Asia-Pacific Region replaced the USA (that moved from the 1st place in the first wave to the 5th position) as the leading region. China, specialising in the export of ICT-equipment, came out on top with the 27.1 % share of digital exports in the country’s total exports, increasing by 15.9 times in 20 years. Russia, whose specialisation is the export of ICT-services, is closer to the end of the top 50 ranking of countries in this segment; its negative foreign trade balance was also revealed. The obtained findings can be useful for specialists developing the foreign digital trade strategy of Russia. In order to increase the potential of national economies, including Russia, in the digital segment of foreign trade, further research should focus on ways to prevent their lagging behind the leaders. © 2022 Institute of Economics, Ural Branch of the Russian Academy of Sciences. All rights reserved

In Vitro Reconstitution of Eukaryotic Translation Reveals Cooperativity between Release Factors eRF1 and eRF3

SummaryEukaryotic translation termination is triggered by peptide release factors eRF1 and eRF3. Whereas eRF1 recognizes all three termination codons and induces hydrolysis of peptidyl tRNA, eRF3's function remains obscure. Here, we reconstituted all steps of eukaryotic translation in vitro using purified ribosomal subunits; initiation, elongation, and termination factors; and aminoacyl tRNAs. This allowed us to investigate termination using pretermination complexes assembled on mRNA encoding a tetrapeptide and to propose a model for translation termination that accounts for the cooperative action of eRF1 and eRF3 in ensuring fast release of nascent polypeptide. In this model, binding of eRF1, eRF3, and GTP to pretermination complexes first induces a structural rearrangement that is manifested as a 2 nucleotide forward shift of the toeprint attributed to pretermination complexes that leads to GTP hydrolysis followed by rapid hydrolysis of peptidyl tRNA. Cooperativity between eRF1 and eRF3 required the eRF3 binding C-terminal domain of eRF1

The role of MRI in the diagnosis of acute radiation reaction in breast cancer patient

A clinical case with acute radiation reaction of the left breast after organ-preserving surgery with 10 Gy IORT (24.8 Gy) conventional radiation therapy has been presented. Comprehensive MRI examination showed signs of radiation- induced damage to skin, soft tissues and vessels of the residual breast

Modeling of plasma jet of vacuum arc with copper-chromium cathode under action of strong axial magnetic field

This paper deals with the computer simulation of a vacuum arc with composite cathode under action of external axial magnetic using hybrid model. The described hybrid model treats the electrons as a massless fluid and ions as macroparticles. It is shown that the average charge state of ions in a jet of a vacuum arc increases with increasing magnetic field. The calculation results are consistent with experimental data. © 2019 IOP Publishing Ltd. All rights reserved.Russian Science Foundation, RSF: 18-19-00069This work was supported by Russian Science Foundation (project No. 18-19-00069)

GTP-dependent structural rearrangement of the eRF1:eRF3 complex and eRF3 sequence motifs essential for PABP binding

Translation termination in eukaryotes is governed by the concerted action of eRF1 and eRF3 factors. eRF1 recognizes the stop codon in the A site of the ribosome and promotes nascent peptide chain release, and the GTPase eRF3 facilitates this peptide release via its interaction with eRF1. In addition to its role in termination, eRF3 is involved in normal and nonsense-mediated mRNA decay through its association with cytoplasmic poly(A)-binding protein (PABP) via PAM2-1 and PAM2-2 motifs in the N-terminal domain of eRF3. We have studied complex formation between full-length eRF3 and its ligands (GDP, GTP, eRF1 and PABP) using isothermal titration calorimetry, demonstrating formation of the eRF1:eRF3:PABP:GTP complex. Analysis of the temperature dependence of eRF3 interactions with G nucleotides reveals major structural rearrangements accompanying formation of the eRF1:eRF3:GTP complex. This is in contrast to eRF1:eRF3:GDP complex formation, where no such rearrangements were detected. Thus, our results agree with the established active role of GTP in promoting translation termination. Through point mutagenesis of PAM2-1 and PAM2-2 motifs in eRF3, we demonstrate that PAM2-2, but not PAM2-1 is indispensible for eRF3:PABP complex formation

Creation of innovative solutions for the production of composite vegetable oils balanced in fatty acid composition

The problem of imbalance of PUFA in a diet of people is investigated. It is proposed to use perspective vegetable sources of oilseeds. Considered the composition and properties of products of processing of vegetable materials of the Russian, which includes ω-3 PUFA. On this basis, the prospects for the use of PUFA in food production are determine

EFFECT OF FERROTHERAPY ON COURSE OF ISCHEMIC HEART DISEASE ASSOCIATED WITH MILD IRON DEFICIENCY IN MEN

Aim. To assess effect of ferrotherapy on course of ischemic heart disease (IHD) associated with mild iron deficiency anemia (IDA) and latent iron deficiency (ID). Material and methods. 80 male patients, coal miners, aged 51±7.9 years, were observed. 28 patients had angina pectoris associated with the mild IDA, 23 patients experienced myocardial infarction accompanied by the mild IDA and 29 patients had angina with latent ID. Latent ID was defined in case of iron plasma level ≤12 µg/l, IDA was diagnosed in case of hemoglobin level <130 mg/l. The minimal hemoglobin level observed in patients was 107g/l. ICD clinical characteristics were compared before and after 3-week iron-based treatment in individualized doses. Results. Latent ID and mild IDA aggravated angina and increased ectopic myocardial activity in patients with IHD. Iron-based therapy with appropriate nutrition reduced angina attacks frequency, duration and intensity, decreased nitroglycerin consumption and increased exercise tolerance. Conclusion. Normalization of haemoglobin level and iron plasma concentration in the mild IDA as well as normalization of iron plasma concentration in ID in patients with IHD reduces ede-ma and dyspnea, decreases heart rate. These effects are provided due to the treatment with elementary iron in individualized course dose, which improves clinical status and minimizes the adverse reactions