Stopping Light All-Optically

We show that light pulses can be stopped and stored all-optically, with a process that involves an adiabatic and reversible pulse bandwidth compression occurring entirely in the optical domain. Such a process overcomes the fundamental bandwidth-delay constraint in optics, and can generate arbitrarily small group velocities for light pulses with a given bandwidth, without the use of any coherent or resonant light-matter interactions. We exhibit this process in optical resonator systems, where the pulse bandwidth compression is accomplished only by small refractive index modulations performed at moderate speeds. (Accepted for publication in Phys. Rev. Lett. Submitted on Sept. 10th 2003)Comment: 18 pages including 3 figures. Accepted for publication in Phys. Rev. Let

Asymptotic Expansions for the Conditional Sojourn Time Distribution in the M/M/1M/M/1-PS Queue

We consider the $M/M/1$ queue with processor sharing. We study the conditional sojourn time distribution, conditioned on the customer's service requirement, in various asymptotic limits. These include large time and/or large service request, and heavy traffic, where the arrival rate is only slightly less than the service rate. The asymptotic formulas relate to, and extend, some results of Morrison \cite{MO} and Flatto \cite{FL}.Comment: 30 pages, 3 figures and 1 tabl

Management of pain in Fabry disease in the UK clinical setting: consensus findings from an expert Delphi panel

Background: Fabry disease is a rare, X-linked inherited lysosomal storage disorder, that manifests as a heterogeneous disease with renal, cardiac and nervous system involvement. The most common pain experienced by people with Fabry disease are episodes of neuropathic pain reported in up to 80% of classical hemizygous male patients and up to 65% of heterozygous female patients. No clear consensus exists within UK clinical practice for the assessment and management of pain in Fabry disease based on agreed clinical practice and clinical experience. Here we describe a modified Delphi initiative to establish expert consensus on management of pain in Fabry disease in the UK clinical setting. Methods: Delphi panel members were identified based on their demonstrated expertise in managing adult or paediatric patients with Fabry disease in the UK and recruited by an independent third-party administrator. Ten expert panellists agreed to participate in two survey rounds, during which they remained anonymous to each other. Circulation of the questionnaires, and collection and processing of the panel’s responses were conducted between September 2021 and December 2021. All questions required an answer. Results: The Delphi panel reached a consensus on 21 out of 41 aspects of pain assessment and management of pain in Fabry disease. These encompassed steps in the care pathway from the goals of therapy through to holistic support, including the use of gabapentin and carbamazepine as first-line analgesic medications for the treatment of neuropathic pain in Fabry disease, as well as the proactive management of symptoms of anxiety and/or depression associated with Fabry pain. Conclusions: The consensus panel outcomes reported here have highlighted strengths in current UK clinical practice, along with unmet needs for further research and agreement. This consensus is intended to prompt the next steps towards developing clinical guidelines

Chapter 12 - Human settlements, infrastructure and spatial planning

Urbanization is a process that involves simultaneous transitions and transformations across multiple dimensions, including demographic, economic, and physical changes in the landscape. Each of these dimensions presents different indicators and definitions of urbanization. The chapter begins with a brief discussion of the multiple dimensions and definitions of urbanization, including implications for GHG emissions accounting, and then continues with an assessment of historical, current, and future trends across different dimensions of urbanization in the context of GHG emissions (12.2). It then discusses GHG accounting approaches and challenges specific to urban areas and human settlements. In Section 12.3, the chapter assesses the drivers of urban GHG emissions in a systemic fashion, and examines the impacts of drivers on individuals sectors as well as the interaction and interdependence of drivers. In this section, the relative magnitude of each driver's impact on urban GHG emissions is discussed both qualitatively and quantitatively, and provides the context for a more detailed assessment of how urban form and infrastructure affect urban GHG emissions (12.4). Here, the section discusses the individual urban form drivers such as density, connectivity, and land use mix, as well as their interactions with each other. Section 12.4 also examines the links between infrastructure and urban form, as well as their combined and interacting effects on GHG emissions. Section 12.5 identifies spatial planning strategies and policy instruments that can affect multiple drivers, and Section 12.6 examines the institutional, governance, and financial requirements to implement such policies. Of particular importance with regard to mitigation potential at the urban or local scale is a discussion of the geographic and administrative scales for which policies are implemented, overlapping, and / or in conflict. The chapter then identifies the scale and range of mitigation actions currently planned and / or implemented by local governments, and assesses the evidence of successful implementation of the plans, as well as barriers to further implementation (12.7). Next, the chapter discusses major co-benefits and adverse side-effects of mitigation at the local scale, including opportunities for sustainable development (12.8). The chapter concludes with a discussion of the major gaps in knowledge with respect to mitigation of climate change in urban areas (12.9)

Schemes of transmission of classical information via quantum channels with many senders: discrete and continuous variables cases

Superadditivity effects in the classical capacity of discrete multi-access channels (MACs) and continuous variable (CV) Gaussian MACs are analysed. New examples of the manifestation of superadditivity in the discrete case are provided including, in particular, a channel which is fully symmetric with respect to all senders. Furthermore, we consider a class of channels for which {\it input entanglement across more than two copies of the channels is necessary} to saturate the asymptotic rate of transmission from one of the senders to the receiver. The 5-input entanglement of Shor error correction codewords surpass the capacity attainable by using arbitrary two-input entanglement for these channels. In the CV case, we consider the properties of the two channels (a beam-splitter channel and a "non-demolition" XP gate channel) analyzed in [Czekaj {\it et al.}, Phys. Rev. A {\bf 82}, 020302 (R) (2010)] in greater detail and also consider the sensitivity of capacity superadditivity effects to thermal noise. We observe that the estimates of amount of two-mode squeezing required to achieve capacity superadditivity are more optimistic than previously reported.Comment: 19 pages, 11 figure

Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation

Background and Purpose Previous work has focussed on changes in drug metabolism caused by altered activity of CYP3A in the presence of inflammation and, in particular, inflammation associated with malignancy. However, drug metabolism involves a number of other P450s, and therefore, we assessed the effect of cancer‐related inflammation on multiple CYP enzymes using a validated drug cocktail. Experimental Approach Patients with advanced stage ovarian cancer and healthy volunteers were recruited. Participants received caffeine, chlorzoxazone, dextromethorphan, and omeprazole as in vivo probes for CYP1A2, CYP2E1, CYP2D6, CYP3A, and CYP2C19. Blood was collected for serum C‐reactive protein and cytokine analysis. Key Results CYP2E1 activity was markedly up‐regulated in cancer (6‐hydroxychlorzoxazone/chlorzoxazone ratio of 1.30 vs. 2.75), while CYP3A phenotypic activity was repressed in cancer (omeprazole sulfone/omeprazole ratio of 0.23 vs. 0.49). Increased activity of CYP2E1 was associated with raised serum levels of IL‐6, IL‐8, and TNF‐α. Repression of CYP3A correlated with raised levels of serum C‐reactive protein, IL‐6, IL‐8, and TNF‐α. Conclusions and Implications CYP enzyme activity is differentially affected by the presence of tumour‐associated inflammation, affecting particularly CYP2E1‐ and CYP3A‐mediated drug metabolism, and may have profound implications for drug development and prescribing in oncological settings

Performance evaluation of turbulence-accentuated interchannel crosstalk for hybrid fibre and free-space optical wavelength-division-multiplexing systems using digital pulse-position modulation

A hybrid fibre and free-space optical communication link using digital pulse-position modulation (DPPM) in a wavelength-division-multiplexing system is proposed. Such a system, which could provide a power efficient, robust and flexible solution to high-speed access networks, is a contender for a passive optical network solution and could readily be deployed in areas with restrictions in optical fibre installation, or alternatively as a disaster recovery network. Interchannel crosstalk and atmospheric turbulence are major impairments in such a system and could combine in some cases to degrade the system. Both impairments are investigated here and the results are presented in the form of bit error probability, required optical transmission power and power penalties. Depending on the position of the interferer relative to the desired user, power penalties of about 0.2–3.0 dB for weak turbulence and above 20 dB for strong turbulence regimes are reported for bit error rate of 10−6. DPPM scheme with a coding level of 2 show about 2 dB improvements over on–off-keying scheme

Familial hypercholesterolaemia: identification and management. Evidence reviews for case-finding, diagnosis and statin monotherapy

This guideline covers identifying and managing familial hypercholesterolaemia (FH), a specific type of high cholesterol that runs in the family, in children, young people and adults. It aims to help identify people at increased risk of coronary heart disease as a result of having FH. In November 2017, we reviewed the evidence for case finding and diagnosis, identification using cascade testing, and management using statins. We amended recommendations in sections 1.1, 1.2 and 1.3

Delayed Capital Injections for a Risk Process with Markovian Arrivals

In this paper we propose a generalisation to the Markov Arrival Process (MAP) risk model, by allowing for a delayed receipt of required capital injections whenever the surplus of an insurance firm is negative. Delayed capital injections often appear in practice due to the time taken for administrative and processing purposes of the funds from a third party or the shareholders of a firm. We introduce a MAP risk model that allows for capital injections to be received instantaneously, or with a random delay, depending on the amount of deficit experienced by the firm. For this model, we derive a system of Fredholm integral equations of the second kind for the Gerber-Shiu function and obtain an explicit expression (in matrix form) in terms of the Gerber-Shiu function of the MAP risk model without capital injections. In addition, we show that the expected discounted accumulated capital injections and the expected discounted overall time in red, up to the time of ruin, satisfy a similar integral equation, which can also be solved explicitly. Finally, to illustrate the applicability of our results, numerical examples are given

Asymptotic Expansions for the Sojourn Time Distribution in the M/G/1M/G/1-PS Queue

We consider the $M/G/1$ queue with a processor sharing server. We study the conditional sojourn time distribution, conditioned on the customer's service requirement, as well as the unconditional distribution, in various asymptotic limits. These include large time and/or large service request, and heavy traffic, where the arrival rate is only slightly less than the service rate. Our results demonstrate the possible tail behaviors of the unconditional distribution, which was previously known in the cases $G=M$ and $G=D$ (where it is purely exponential). We assume that the service density decays at least exponentially fast. We use various methods for the asymptotic expansion of integrals, such as the Laplace and saddle point methods.Comment: 45 page