When to Leave the Stones Unturned: Using Proportionality to Navigate Discovery Efficiently, Effectively, and Ethically

Discovery is intended to be an efficient, truth-seeking process with the ultimate goal of achieving just, speedy, and inexpensive dispute resolution. However, the consistent and extensive abuse of discovery has cast a shadow on the intended purpose of the process. For various ill- and well-intentioned reasons, attorneys abuse the process by conducting unnecessarily excessive and expensive discovery. One such reason for excessive and expensive discovery—and the focus of this Article—is the over-zealous advocacy of attorneys who leave no stone unturned out of fear of legal malpractice claims. To combat such excessive and expensive discovery, the Federal Rules of Civil Procedure emphasize a proportionality principle to limit the scope of discovery. But, despite the many revisions and amendments, the practicalities of the proportionality principle still remain ambiguous. In an attempt to resolve ambiguity, this Article offers realistic methods attorneys can implement to achieve proportionality in discovery, such as early case assessments, fact-finder assessments, written agreements with clients, and early judicial involvement. Furthermore, this Article proposes an ethical safeharbor to be added to the ABA Model Rules of Professional Conduct to protect well-intentioned attorneys who utilize the suggested proportionality methods. With these suggested proportionality methods and the proposed safe-harbor, this Article endeavors to curtail discovery abuse, protect attorneys, and allow for greater access to affordable and attainable justice

Assessment of Natural Resources Use for Sustainable Development - DPSIR Framework for Case Studies in Portsmouth and Thames Gateway, U.K.

This chapter reports on the uses of the DPSIR framework to assess the sustainability of the intertidal environments within the two UK case study areas, Portsmouth and Thames Gateway. It focuses on statutory conservation areas dominated by intertidal habitats. Two are located in Portsmouth (Portsmouth and Langstone Harbours) and four in the Thames Gateway (Benfleet Marshes, South Thames Estuary, Medway Estuary and the Swale in the Thames Gateway). Based on the reduction of a number of pressures and impacts observed in recent decades and the improvement of overall environmental quality, all six SSSIs are considered to be sustainable in the short and medium term. In the future, it is possible that the impacts of climate change, especially sea-level rise, might result in further reduction in the area and/or quality of intertidal habitats. Further integration between conservation and planning objectives (both for urban development and management of flood risk) at local level is needed to support the long-term sustainability of intertidal habitats

Augmented GNSS Differential Corrections Minimum Mean Square Error Estimation Sensitivity to Spatial Correlation Modeling Errors

Railway signaling is a safety system that has evolved over the last couple of centuries towards autonomous functionality. Recently, great effort is being devoted inthis field, towards the use and exploitation of Global Navigation Satellite System (GNSS)signals and GNSS augmentation systems in view of lower railway track equipments andmaintenance costs, that is a priority to sustain the investments for modernizing the local andregional lines most of which lack automatic train protection systems and are still manuallyoperated. The objective of this paper is to assess the sensitivity of the Linear Minimum MeanSquare Error (LMMSE) algorithm to modeling errors in the spatial correlation function thatcharacterizes true pseudorange Differential Corrections (DCs). This study is inspired bythe railway application; however, it applies to all transportation systems, including the roadsector, that need to be complemented by an augmentation system in order to deliver accurateand reliable positioning with integrity specifications. A vector of noisy pseudorange DCmeasurements are simulated, assuming a Gauss-Markov model with a decay rate parameterinversely proportional to the correlation distance that exists between two points of a certainenvironment. The LMMSE algorithm is applied on this vector to estimate the true DC, andthe estimation error is compared to the noise added during simulation. The results show thatfor large enough correlation distance to Reference Stations (RSs) distance separation ratiovalues, the LMMSE brings considerable advantage in terms of estimation error accuracy and precision. Conversely, the LMMSE algorithm may deteriorate the quality of the DCmeasurements whenever the ratio falls below a certain threshold

Variational control approach to energy extraction from a fluid flow

Energy harvesting from the environment is an important aspect of many technologies. The scale of energy capturing and storage can involve the power range from mWatt up to MWatt, depending on the used devices and the considered environments (from ambient acoustic and vibration to ocean wave motion, or wind). In this paper, the wind turbine energy harvesting problem is approached as an optimal control problem, where the objective function is the absorption of an amount of energy in a given time interval by a fluid-flow environment, that should be maximized. The interest relies on outlining general control models of fluid-flow-based extraction plants and identifying an optimum strategy for the regulation of an electrical machine to obtain a maximum-efficiency process for the related energy storage. The mathematical tools are found in the light of optimal control theory, where solutions to the fundamental equations are in the frame of Variational Control (the basis of the Pontryagin optimal control theory). A special problem, named Optimally Controlled Betz’s Machine OCBM-optimal control steady wind turbine, is solved in closed form, and it is shown that, in the simpler steady case, it reproduces the maximum efficiency machine developed in Betz’s theory

Biomarkers in Early Response to Brolucizumab on Pigment Epithelium Detachment Associated with Exudative Age-Related Macular Degeneration.

The purpose of this study was to describe early changes in the morphology of pigment epithelium detachments (PED) after an intravitreal injection of Brolucizumab into eyes with macular neovascularization secondary to exudative age-related macular degeneration (e-AMD). We included twelve eyes of 12 patients with PED secondary to e-AMD which were not responding to prior anti-VEGF treatments. An ophthalmic examination and an assessment of PED-horizontal maximal diameter (PED-HMD), PED-maximum high (PED-MH) and macular neovascularization (MNV) flow area (MNV-FA) by the means of structural optical coherence tomography (OCT) and OCT Angiography (OCT-A) were performed at baseline, as well as 1, 7, 14 and 30 days after the injection. The mean age of the population of study was 78.4 (SD ± 4.8). The mean number of previous Ranibizumab or Aflibercept injections was 13 (SD ± 8). At the last follow-up visit, the PED-HMD did not significantly change (p = 0.16; F(DF:1.94, 20,85) = 1.9), the PED-MH showed a significant reduction [p = 0.01; F(DF:1.31, 14.13) = 6.84.] and the MNV-FA did not significantly differ (p = 0.1; F(1.97, 21.67) = 2.54) from baseline. No signs of ocular inflammation were observed during follow-up. A single Brolucizumab injection was able to determine the short-term effects on PEDs' anatomical features of eyes with an unresponsive e-AMD

Computational fluid dynamics simulations of blood flow regularized by 3D phase contrast MRI

Abstract Background Phase contrast magnetic resonance imaging (PC-MRI) is used clinically for quantitative assessment of cardiovascular flow and function, as it is capable of providing directly-measured 3D velocity maps. Alternatively, vascular flow can be estimated from model-based computation fluid dynamics (CFD) calculations. CFD provides arbitrarily high resolution, but its accuracy hinges on model assumptions, while velocity fields measured with PC-MRI generally do not satisfy the equations of fluid dynamics, provide limited resolution, and suffer from partial volume effects. The purpose of this study is to develop a proof-of-concept numerical procedure for constructing a simulated flow field that is influenced by both direct PC-MRI measurements and a fluid physics model, thereby taking advantage of both the accuracy of PC-MRI and the high spatial resolution of CFD. The use of the proposed approach in regularizing 3D flow fields is evaluated. Methods The proposed algorithm incorporates both a Newtonian fluid physics model and a linear PC-MRI signal model. The model equations are solved numerically using a modified CFD algorithm. The numerical solution corresponds to the optimal solution of a generalized Tikhonov regularization, which provides a flow field that satisfies the flow physics equations, while being close enough to the measured PC-MRI velocity profile. The feasibility of the proposed approach is demonstrated on data from the carotid bifurcation of one healthy volunteer, and also from a pulsatile carotid flow phantom. Results The proposed solver produces flow fields that are in better agreement with direct PC-MRI measurements than CFD alone, and converges faster, while closely satisfying the fluid dynamics equations. For the implementation that provided the best results, the signal-to-error ratio (with respect to the PC-MRI measurements) in the phantom experiment was 6.56 dB higher than that of conventional CFD; in the in vivo experiment, it was 2.15 dB higher. Conclusions The proposed approach allows partial or complete measurements to be incorporated into a modified CFD solver, for improving the accuracy of the resulting flow fields estimates. This can be used for reducing scan time, increasing the spatial resolution, and/or denoising the PC-MRI measurements.http://deepblue.lib.umich.edu/bitstream/2027.42/116061/1/12938_2015_Article_104.pd

Choroidal Changes in Blood Flow in Patients with Intermediate AMD after Oral Dietary Supplement Based on Astaxanthin, Bromelain, Vitamin D3, Folic Acid, Lutein, and Antioxidants

Background and Objectives: The aim of this study was to investigate the impact of oral administration of the combination of astaxanthin (AXT), lutein, folic acid, vitamin D3, and bromelain with antioxidants on choroidal blood flow in patients with age-related intermediate macular degeneration (AMD). Materials and Methods: Patients affected by intermediate AMD and treated with daily oral nutritional supplement with AXT, bromelain, vitamin D3, folic acid, lutein, and antioxidants for a period of at least 6 months were included in this retrospective study. A control group homogenous for age and sex was also included in the analysis. All participants underwent a complete ophthalmologic examination, spectral domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (OCTA) evaluation. Outcome measures were choroidal thickness (CHT) and choriocapillary vessel density (CCVD) after six months of AXT assumption. Results: CCVD values showed statistically significant difference between cases and controls at baseline (p < 0.001) and in the cases during follow-up (p < 0.001). The CHT measurements showed statistically significant difference between cases and controls (p = 0.002) and in the cases during follow-up (p < 0.001). Conclusions: The combined use of structural OCT and OCTA allows for a detailed analysis in vivo of perfusion parameters of the choriocapillaris and choroid and evaluation of changes of choroidal blood flow after oral nutritional supplements that affect blood flow velocity