Sinteza i anthelmintičko djelovanje novih 2-supstituiranih-4,5-difenil imidazola

A series of 2-substituted-4,5-diphenyl imidazoles 1a-j were synthesized by refluxing benzil with different substituted aldehydes in the presence of ammonium acetate and glacial acetic acid. Structures of the synthesized compounds were confirmed on the basis of IR, 1H NMR and mass spectral data. Compounds 1a-j were screened for anthelmintic activity. Test results revealed that compounds showed paralysis time of 0.24 to 1.54 s and death time of 0.39 to 4.40 s while the standard drugs albendazole and piperazine citrate showed paralysis time of 0.54 and 0.58 s and death time of 2.16 and 2.47 s, respectively, at the same concentration of 1 % (m/V). Five compounds, 2-[2-hydroxyphenyl]-4,5-diphenyl imidazole (1b), 2-[3-methoxyphenyl]-4,5-diphenyl imidazole (1c), 2-[2-phenylethenyl]-4,5-diphenyl imidazole (1e), 2-[4-fluorophenyl]-4,5-diphenyl imidazole (1g) and 2-[3-nitrophenyl]-4,5-diphenyl imidazole (1h) showed significant anthelmintic activity compared to the standard drugs.Refluksiranjem benzila s različitim supstituiranim aldehidima u prisutnosti amonijeva acetata i ledene octene kiseline sintetizirana je serija 2-supstituiranih-4,5-difenil imidazola (1a-j). Strukture sintetiziranih spojeva potvrđene su IR, 1H NMR i masenom spektroskopijom. U testovima na anthelmintičko djelovanje određeno je vrijeme paralize 0,24 do 1,54 min i vrijeme smrti 0,39 do 4,40 min, dok standarni lijekovi albendazol i piperazin citrat imaju vrijeme paralize 0,54 i 0,58 min, a vrijeme smrti 2,16, odnosno 2,47 min pri istim koncentracijama (1 % m/V). Pet spojeva, 2-[2-hidroksifenil]-4,5-difenil imidazol (1b), 2-[3-metoksifenil]-4,5-difenil imidazol (1c), 2-[2-feniletenil]-4,5-difenil imidazol (1e), 2-[4-fluorofenil]-4,5-difenil imidazol (1g) i 2-[3-nitrofenil]-4,5-difenil imidazol (1h) pokazuju značajno anthelmintičko djelovanje u odnosnu na standardne lijekove

Electrochemical oxidation of Cu-EDTA on boron doped diamond (BDD) electrode

No Abstract. Global Journal of Pure and Applied Sciences Vol. 12 (4) 2006: 577-58

Investigation of IrO2/Ta2O5 Thin Film Evolution

The thermal evolution process of IrO2–Ta2O5/Ti coatings with varying noble metal content has been investigated under in situ conditions by thermogravimetry combined with mass spectrometry. The gel-like films prepared from alcoholic solutions of the precursor salts (IrCl3·3H2O and TaCl5) onto titanium metal support were heated in an atmosphere containing 20% O2 and 80% Ar up to 600 °C. The liberation of the chlorinated species followed by the mass spectrometric ion intensity curves showed that the two oxide phases do not develop independently. The cracking of retained solvent, the combustion of organic surface species formed (and elemental carbon trapped in the film) was also followed by the MS curves. The formation of carbonyl- and carboxylate-type surface species connected to the noble metal were identified by Fourier transform infrared emission spectroscopy (IRES). These secondary processes—catalyzed by the noble metal—play an important role in the development of surface morphology of the films when used as anode materials in oxygen evolution reactions

Use of antimicrobial edible films and coatings as packaging materials for food safety

In recent years, the packaging industry has also started to research new technologies due to increased consumer demand for the minimally processed foods. One of these new technologies is edible films and coatings produced from natural polymers such as protein, polysaccharide, and lipid derived which are biodegradable and could be used as active packaging material. Researches on the use of edible films as packaging materials continue because of the potential of these films to enhance food quality, food safety, and product shelf life. Edible films and coatings have many advantages such as biodegradability, edibility, bio-compatibility with aesthetic appearance and barrier properties against oxygen, ability to resist physical stress. Edible films and coatings are also can be used as a carrier of natural or chemical antimicrobial agents such as organic acids, chitosan, nisin, lactoperoxidase system, and some other plant extracts and essential oils. So they may reduce the risks of growth of spoilage or pathogenic microorganisms in foods by the addition of antimicrobial substances in edible films and coatings and so can prolong the shelf life of foods. Choosing the active antimicrobial is important to prolong shelf life. For effective antimicrobial selection, some possible interactions must be considered such as between the target microorganisms and antimicrobial, film-forming biopolymer, and other food components. In recent years, effective results have been achieved by using antimicrobial edible films and coatings and some model systems have established. In this chapter, the history of antimicrobial edible films and coatings, evaluation of edible packaging performance, characteristics of biopolymers and antimicrobial substances which are used for preparation of antimicrobial edible film coatings, functional properties, legal and economic aspects, some food applications, and the place and importance of antimicrobial edible films and coatings in future reviewed. © 2014, Springer Science+Business Media New York