Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

International audience; The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system

Fast dose fractionation using ultra-short laser accelerated proton pulses can increase cancer cell mortality, which relies on functional PARP1 protein

International audienceRadiotherapy is a cornerstone of cancer management. The improvement of spatial dose distribution in the tumor volume by minimizing the dose deposited in the healthy tissues have been a major concern during the last decades. Temporal aspects of dose deposition are yet to be investigated. Laser-plasma-based particle accelerators are able to emit pulsed-proton beams at extremely high peak dose rates (~109 Gy/s) during several nanoseconds. The impact of such dose rates on resistant glioblastoma cell lines, SF763 and U87-MG, was compared to conventionally accelerated protons and X-rays. No difference was observed in DNA double-strand breaks generation and cells killing. The variation of the repetition rate of the proton bunches produced an oscillation of the radio-induced cell susceptibility in human colon carcinoma HCT116 cells, which appeared to be related to the presence of the PARP1 protein and an efficient parylation process. Interestingly, when laser-driven proton bunches were applied at 0.5 Hz, survival of the radioresistant HCT116 p53-/- cells equaled that of its radiosensitive counterpart, HCT116 WT, which was also similar to cells treated with the PARP1 inhibitor Olaparib. Altogether, these results suggest that the application modality of ultrashort bunches of particles could provide a great therapeutic potential in radiotherapy

Experimental assessment of various optical communication chains for high-capacity optical feeder links

Optical feeder links (OFL) are expected to become part of future Very High Throughput Satellite (VHTS) systems in response to the growing demand for higher capacity and lower costs. H2020 VERTIGO (Very High Throughput Satellite Ground Optical Link) project was set to prove key optical communication technologies and to address: 1) Throughput increase with high spectral and power efficiencies. 2) Higher optical power generation and delivery. 3) Atmospheric turbulence mitigation by optical and digital processing

Characterization of the ELIMED prototype permanent magnet quadrupole system

International audienceThe system described in this work is meant to be a prototype of a more performing one that will be installed at ELI-Beamlines in Prague for the collection of ions produced after the interaction Laser-target, [2]. It has been realized by the researchers of INFN-LNS (Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare) and SIGMAPHI, a French company, using a system of Permanent Magnet Quadrupoles (PMQs), [1]. The final system that will be installed in Prague is designed for protons and carbons up to 60MeV/u, around 10 times more than the energies involved in the present work. The prototype, shown in this work, has been tested in collaboration with the SAPHIR experimental facility group at LOA (Laboratoire d'Optique Applique) in Paris using a 200 TW Ti:Sapphire laser system. The purpose of this work is to validate the design and the performances of this large and compact bore system and to characterize the beam produced after the interaction laser-target and its features. Moreover, the optics simulations have been compared with a real beam shape on a GAF Chromic film. The procedure used during the experimental campaign and the most relevant results are reported here demonstrating a good agreement with the simulations and a good control on the beam optics