ГЕНИТАЛЬНЫЙ ТУБЕРКУЛЕЗ И ВСПОМОГАТЕЛЬНЫЕ РЕПРОДУКТИВНЫЕ ТЕХНОЛОГИИ

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РОЛЬ ГЕНИТАЛЬНОГО ТУБЕРКУЛЕЗА В НЕБЛАГОПРИЯТНЫХ ИСХОДАХ ЭКСТРАКОРПОРАЛЬНОГО ОПЛОДОТВОРЕНИЯ

Prospective integral laboratory and instrumental examinations were performed in 110 infertile women The examined women were divided into 2 groups: the main group included 60 patients with infertility associated with genital tuberculosis, while the control group included 50 women with infertility of non-tuberculous etiology (control group) 16 couples from the main group and 17 couples from the control group had their fertility restored through in vitro fertilization Take-home baby rate, which is the main rate reflecting IVF efficiency was lower in case of tuberculosis-associated infertility compared to the control group (2353% versus 375%), while the frequency of spontaneous abortions was higher (250% and 176%) The lack of timely diagnostics and treatment of latent tuberculous infection (25%) and endometrial lesions (50%) are the main causes of unfavorable outcomes of IVF Pregnancy resulting from IVF in case of infertility due to tuberculosis is associated with high risks of complicated gestation, premature birth, maternal and perinatal diseases.Проведено проспективное комплексное лабораторно-инструментальное исследование 110 женщин с бесплодием Обследованные женщины разделены на 2 группы: 60 пациенток с бесплодием, ассоциированным с генитальным туберкулезом (основная группа), и 50 женщин с бесплодием нетуберкулезной этиологии (контрольная группа) В основной группе у 16, в контрольной группе у 17 супружеских пар восстановление фертильности проведено с помощью программы экстракорпорального оплодотворения (ЭКО) Основной показатель эффективности программы ЭКО take-home baby rate при туберкулезном бесплодии ниже, чем в контрольной группе (23,53% против 37,5%), а частота самопроизвольных выкидышей в I триместре, наоборот, выше (25,0 и 17,6%) Отсутствие своевременной диагностики и лечения скрытой туберкулезной инфекции (25%) и эндометриальных поражений (50%) является главной причиной неблагоприятных исходов ЭКО Беременность в результате ЭКО при бесплодии туберкулезного генеза связана с повышением риска осложнений гестации, преждевременных родов, репродуктивных потерь, материнской и перинатальной заболеваемости

Генерализованный туберкулез и многоплодная беременность

The article describes a clinical case of successful treatment of generalized tuberculosis in a young immunocompetent woman with multifetal pregnancy (triplets) and multiple localizations of tuberculosis: tuberculosis meningitis, disseminated pulmonary tuberculosis, and uterine tuberculosis. Specific parameters of tuberculosis diagnostics in the pregnant are presented.Приведено клиническое наблюдение успешного лечения генерализованного туберкулеза у молодой иммунокомпетентной женщины с многоплодной беременностью тройней и множественной локализацией туберкулеза: туберкулезный менингит, диссеминированный туберкулез легких, туберкулез матки. Показаны особенности диагностики туберкулеза при беременности

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

ROLE OF GENITAL TUBERCULOSIS IN UNFAVORABLE OUTCOMES OF IN VITRO FERTILIZATION

Prospective integral laboratory and instrumental examinations were performed in 110 infertile women The examined women were divided into 2 groups: the main group included 60 patients with infertility associated with genital tuberculosis, while the control group included 50 women with infertility of non-tuberculous etiology (control group) 16 couples from the main group and 17 couples from the control group had their fertility restored through in vitro fertilization Take-home baby rate, which is the main rate reflecting IVF efficiency was lower in case of tuberculosis-associated infertility compared to the control group (2353% versus 375%), while the frequency of spontaneous abortions was higher (250% and 176%) The lack of timely diagnostics and treatment of latent tuberculous infection (25%) and endometrial lesions (50%) are the main causes of unfavorable outcomes of IVF Pregnancy resulting from IVF in case of infertility due to tuberculosis is associated with high risks of complicated gestation, premature birth, maternal and perinatal diseases

Generalized tuberculosis and multifetal pregnancy

The article describes a clinical case of successful treatment of generalized tuberculosis in a young immunocompetent woman with multifetal pregnancy (triplets) and multiple localizations of tuberculosis: tuberculosis meningitis, disseminated pulmonary tuberculosis, and uterine tuberculosis. Specific parameters of tuberculosis diagnostics in the pregnant are presented