Influence of antidysbiotic drugs on the liver of rats with experimental non-alcoholic steatohepatitis

High-fat diets combined with the introduction of lincomycin causes the development of steatohepatitis. Introduction antidysbiotic drugs (pro- and prebiotics) has a therapeutic effect

Keldysh Ginzburg-Landau action of fluctuating superconductors

We derive Ginzburg-Landau action by systematically integrating out electronic degrees of freedom in the framework of the Keldysh nonlinear sigma-model of disordered superconductors. The resulting Ginzburg-Landau functional contains a nonlocal $\Delta$-dependent contribution to the diffusion constant, which leads, for example, to Maki-Thompson corrections. It also exhibits an anomalous Gor'kov-Eliashberg coupling between $\Delta$ and the scalar potential, as well as a peculiar nonlocal nonlinear term. The action is gauge invariant and satisfies the fluctuation dissipation theorem. It may be employed e.g. for calculation of higher moments of the current fluctuations.Comment: 16 pages, 2 figure

Spatial beam self-cleaning and supercontinuum generation with Yb-doped multimode graded-index fiber taper based on accelerating self-imaging and dissipative landscape

We experimentally demonstrate spatial beam self-cleaning and supercontinuum generation in a tapered Ytterbium-doped multimode optical fiber with parabolic core refractive index profile when 1064 nm pulsed beams propagate from wider (122 µm) into smaller (37 µm) diameter. In the passive mode, increasing the input beam peak power above 20 kW leads to a bell-shaped output beam profile. In the active configuration, gain from the pump laser diode permits to combine beam self-cleaning with supercontinuum generation between 520-2600 nm. By taper cut-back, we observed that the dissipative landscape, i.e., a non-monotonic variation of the average beam power along the MMF, leads to modal transitions of self-cleaned beams along the taper length

Hepatoprotective effect of antidysbiotic drugs in experimental metabolic syndrome

Modeling of experimental metabolic syndrome in Wistar male rats was accompanied by a sharp increase in neutrophils/lymphocytes ratio and decrease in the numbers of monocytes in the blood, as well as almost 5-fold increase in the urease activity, a 3-fold decrease in the activity of lysozyme, and significant increase in the levels of inflammatory markers (MDA and elastase) in the liver. A 13-fold increase was observed in the level of dysbiosis in the liver and a significant increase in the alkaline phosphatase activity. Using antidysbiotic drugs (Quertulin, Quertgial and lysozyme) normalized the state of liver

Problematic issues of endoscopic biliary stenting

Objective. To study the results of endoscopic biliary stenting (EBS) for biliary obstruction of various genesis to determine the problematic issues of the procedure and possibility of its efficacy raising. Materials and methods. Experience of conduction of 5748 endoscopic transpapillary interventions in 2010 - 2017 yrs was analyzed: endoscopic papillosphincterotomy was performed in 2919 (50.8%) observations, stenting of biliary ducts - in 379 (6.6%). In 296 (78.1%) observations plastic stents (PS) were introduced, while in 83 (21.9%) – the self-expanding metallic stents. Results. Of 208 patients, in whom primary temporary EBS was performed for tumoral biliary obstruction, using PS, in 153 (73.6%) the next stage of treatment have constituted elective  operation in 10 - 14 days after elimination of hyperbilirubinemia, signs of cholangitis, additional examination and determination of the intervention volume. Among these patients in 56 (36.6%) radical operations were performed, and in 97 (63.4%) – palliative operations. In 47 patients PS for closure of external biliary fistula (EBS) PS was introduced: in 13 (27.7%) – for tubular stenosis of distal part of common biliary duct, in 7 (14.9%) – for insufficiency of sutures of common biliary duct (after choledocholithotomy), in 14 (29.8%) – for intraoperative damages of extrahepatic biliary ducts, in 5 (10.6%) – for presence of Luschka channels, in 8 (17.0%) – for a state after hepatic resection, echinococectomy. Presence of concrements, which due to some reasons were not removed endocopically, in environment of purulent cholangitis have constituted the indication for performance of EBS in 24 (8.1%) observations, chronic pancreatitis, complicated by obturation jaundice – in 9 (3.0%). Correction of iatrogenic damages of biliary ducts with development of their partial strictures, EBF, using EBS with introduction of PS, were performed in 8 (2.7%) patients. Conclusion. The necessity exists to study the treatment results in patients, suffering biliary obstruction of various genesis, to determine problematic issues of the main procedures and possibilities of their efficacy raising

Decay of the turbulent cascade of capillary waves on the charged surface of liquid hyrdrogen.

We study the free decay of capillary turbulence on the charged surface of liquid hydrogen. We find that the decay begins from the high frequency spectral domains of the surface oscillations and is of a quasi-adiabatic character. The characteristic relaxation time of the whole turbulent cascade is close to the viscous damping time for capillary waves of frequency equal to the driving frequency

Nanotube-based source of charges for experiments with solid helium at low temperatures

Methods of preparation of the field-emission sources of charges from carbon nanotubes suitable for study of injected charges in solid helium at low temperatures T < 1 K are presented. The sources have been prepared by arc discharge deposition of nanotubes onto a flat copper substrate or by mechanical rubbing of nanotubes into porous metal surface. The test study of the voltage-current characteristics of a diode cell with the nanotube source in superfluid He II have shown that at voltages above 120 V one can observe a relatively large current I ≥ 10⁻¹³ A of negative charges in liquid helium. The field and temperature dependences of positive and negative currents in solid ⁴He were studied in samples grown by the blocked capillary technique. Usage of the nanotube based source of injected charges had permitted us for the first time to observe motion of the positive charges in solid helium at temperatures below 0.1 К. The current-voltage dependence could be described by a power law I ~ Uα, with the value of the exponent α >> 2, much higher than what one would expect for the regime of space charge limited currents

Hypoxia-inducible Factor-dependent Breast Cancer-mesenchymal Stem Cell Bidirectional Signaling Promotes Metastasis.

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