Star formation in early-type galaxies: the role of stellar winds and kinematics

Early-type galaxies (ETGs) host a hot ISM produced mainly by stellar winds, and heated by Type Ia supernovae and the thermalization of stellar motions. High resolution 2D hydrodynamical simulations showed that ordered rotation in the stellar component results in the formation of a centrifugally supported cold equatorial disc. In a recent numerical investigation we found that subsequent generations of stars are formed in this cold disc; this process consumes most of the cold gas, leaving at the present epoch cold masses comparable to those observed. Most of the new stellar mass formed a few Gyrs ago, and resides in a disc.Comment: 2 pages, 1 figure, to appear in proceedings of IAU Symposium 315, "From Interstellar Clouds to Star-Forming Galaxies: Universal Processes?", P. Jablonka, F. Van der Tak & P. Andre', ed

The Effect of the AGN Feedback on the Interstellar Medium of Early-Type Galaxies: 2D Hydrodynamical Simulations of the Low-Rotation Case

We present 2D hydrodynamical simulations for the evolution of early-type galaxies containing central massive black holes (MBHs), starting at age 2 Gyr. The code contains accurate and physically consistent radiative and mechanical AGN wind feedback, with parsec-scale central resolution. Mass input comes from stellar evolution; energy input includes Type Ia and II supernova and stellar heating; star-formation is included. Realistic, axisymmetric dynamical models for the galaxies are built solving the Jeans' equations. The lowest mass models (Mstar = 8 10^{10}Msun) develop global outflows sustained by SNIa's heating, ending with a significantly lower amount of hot gas and new stars. In more massive models, nuclear outbursts last to the present epoch, with large and frequent fluctuations in nuclear emission and from the gas (Lx). Each burst last ~ 10^{7.5} yr, during which (for r < 2-3 kpc) cold, inflowing, and hot, outflowing gas phases coexist. The Lx-T relation for the gas matches that of local galaxies. AGN activity causes positive feedback for star formation. Roughly half of the total mass loss is recycled into new stars (DeltaMstar), just ~ 3% of it is accreted on the MBH, the remainder being ejected from the galaxy. The ratio between the mass of gas expelled to that in to new stars, the load factor, is ~0.6. Rounder galaxies shapes lead to larger final MBH masses, DeltaMstar, and Lx. Almost all the time is spent at very low nuclear luminosities, yet one quarter of the total energy is emitted at an Eddington ratio > 0.1. The duty-cycle of AGN activity approximates 4% (Abridged).Comment: 26 pages, 15 figure, submitted to ApJ. Comments welcom

Landrace added value and accessibility in Europe: what a collection of case studies tells us

In the actual climate change scenario, in situ conservation of plant genetic resources for food and agriculture can significantly contribute broadening the diversity of our food system as well as increasing its resilience; nevertheless, landrace cultivation has been dramatically reduced in the last decades all over Europe. One of the most effective approaches to counteract the loss of landrace diversity in situ is facilitating its use. Aims of this study were to (i) describe how in situ maintenance of landraces occurs in different agro-environmental conditions in Europe and (ii) identify the main factors influencing landrace added values and accessibility as means to increase their adoption by new farmers. To the purpose, a collection of 95 case studies of both garden and open field landraces maintained in situ was analysed. A first description was obtained by classifying the information into 18 purposely defined categories. Data on landraces added values and accessibility were further transformed into weighted variables; the derived quantitative scores were then used as dependent variables in univariate and multivariate analyses. Results showed that farmers alone are still the main actors maintaining landraces in situ across different European biogeographical regions, mainly carrying out their activity under organic or low-input conditions, often in marginal areas. Results of the multivariate analysis showed that (i) type of actor involved in the multiplication, (ii) the main use of the product and (iii) presence of promotion actions significantly affect garden landraces added value and accessibility; presence of promotion actions was the only factor affecting added value of open field entries. Evidence arising from this work can contribute to the establishment of a fruitful ground of discussion for future European policies and strategies to protect and increase landrace use

Ploes: percorsi tra archeologia, storia e tecnologie informatiche

The systematic study of imports from the Orient uncovered in funerary contexts, as part of a research project the purpose of which is the reconstruction of the trade and cultural relations between the Aegean and the oriental basin of the Mediterranean in the Early Iron Age, has been supported by the relational database Ploes carried out in a MsAccess 2000 environment. Ploes represents an example of the possible meeting point between computer science and historical-archaeological research and testifies to the contribution that the computer science technologies can also offer to studies of the traditional school. The digital archives, that have replaced the conventional catalogue, have allowed the management of great amounts of data (1000 imported objects distributed in 300 tomb contexts) in a way that is functional for the purposes of research thanks to the possibility of creating a multiplicity of paths for reading the material. The Ploes database has allowed the storage of data related to individual objects and their discovery contexts in a single archive, thus making it possible to adopt a contextual approach to the analysis of the archaeological documentation. The structure of the digital archives reflects the defined methodological plan at the level of theoretical formulation of the study project: Ploes represents therefore not simply a container of information but an indispensable research instrument

IDSC Hecla Response to USA Appeal

Hecla Limited\u27s Consolidated Response to the United States\u27 Appea

IDSC Hecla Response to CDAT Appeal

Hecla Limited\u27s Consolidated Response to the Coeur d\u27Alene Tribe\u27s Appea

IDSC Hecla Response to USA Appeal

Hecla Limited\u27s Consolidated Response to the United States\u27 Appea

IDSC Hecla Response to CDAT Appeal

Hecla Limited\u27s Consolidated Response to the Coeur d\u27Alene Tribe\u27s Appea

KRAS: A Druggable Target in Colon Cancer Patients

Mutations in KRAS are among the most frequent aberrations in cancer, including colon cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule inhibition. Moreover, its elevated affinity to cellular guanosine triphosphate (GTP) has made the design of specific drugs challenging. Indeed, KRAS was considered ‘undruggable’. KRASG12C is the most commonly mutated variant of KRAS in non-small cell lung cancer. Currently, the achievements obtained with covalent inhibitors of this variant have given the possibility to assess the best therapeutic approach to KRAS-driven tumors. Mutation-related biochemical assets and the tissue of origin are expected to influence responses to treatment. Further attempts to obtain mutant-specific KRAS (KRASG12C) switch-II covalent inhibitors are ongoing and the results are promising. Drugs targeted to block KRAS effector pathways could be combined with direct KRAS inhibitors, immunotherapy or T cell-targeting approaches in KRAS-mutant tumors. The development of valuable combination regimens will be essential against potential mechanisms of resistance that may arise during treatment

Italian Validation of the Meaning in Life Questionnaire: Factor Structure, Reliability, Convergent and Discriminant Validity

Several studies highlighted the role of meaning in life as a major component of well-being. Researchers developed different instruments to assess the features of this construct. In the present study the psychometric properties of the Meaning in Life Questionnaire (MLQ; Steger, Frazier, Oishi, & Kaler, 2006) were investigated in the Italian context. The MLQ is a 10-item scale measuring perceived presence of and search for meaning in life, conceptualized as two separate factors. The former refers to perceived meaning and purpose in life, the latter to the active commitment to find meaning in life. Participants were 464 adults aged 20-60 (M=39.34; SD=10.86; 54.7% women). Factor structure was inspected through exploratory and confirmatory factor analyses using a split-sample approach. Internal consistency was assessed through Cronbach\u2019s alphas, inter-item and item-scale correlations. Convergent and discriminant validity with measures of well-being, personality, mental and physical health were also evaluated. Factor analyses supported the adequacy of the MLQ two-factor structure in the Italian context; internal consistency measures corroborated the instrument\u2019s reliability; and correlation matrix coefficients sustained convergent and discriminant validity. Results showed that the MLQ is a valid and reliable measure to assess meaning in life and its relationship with well-being within the Italian context