The Effects of Bacterial Endotoxin LPS on Synaptic Transmission at the Neuromuscular Junction

The direct action of bacterial lipopolysaccharides (LPS) endotoxin was shown to enhance synaptic transmission and hyperpolarize the membrane potential at low doses, but block glutamatergic receptors and decrease observable spontaneous events at a high dosage. The dosage effects are LPS type specific. The hyperpolarization is not due to voltage-gated potassium channels or to activation of nitric oxide synthase (NOS). The effects are induced directly by LPS, independent of an immune response

Understanding the dynamic momentum aperture of the Advanced Light Source

The lifetime of a light source with small emittance like the Advanced Light Source (ALS) is usually limited by the momentum acceptance of the ring. Large momentum acceptances are reached by providing enough RF voltage and by avoiding a degradation of the dynamic momentum aperture. At the ALS the size of the momentum acceptance depends strongly on the transverse dynamics. It is very sensitive to machine conditions such as the tunes and chromaticities since depending on those conditions the Touschek scattered particles explore different resonance regions in the phase space. In this paper we show that by using a single-turn ’pinger’ magnet together with turn-byturn beam position monitors (BPM) one can identify the cause of a reduction in momentum acceptance and take steps to improve the acceptance

Assessment of Synaptic Function During Short-Term Facilitation in Motor Nerve Terminals in the Crayfish

An enhanced buildup of [Ca2+]i occurs during short-term facilitation (STF) at the crayfish neuromuscular junction (NMJ). As a model system, this NMJ allows discrete postsynaptic quantal events to be counted and characterized in relation to STF. Providing 10 pulses, at 20 and 40Hz, we monitored postsynaptic quantal events over a discrete region of a nerve terminal with a focal macropatch electrode. Characteristics of quantal events were clustered into groups by peak amplitude and time to the peak amplitude. Since the synapses at this NMJ have varied spacing of active zones, number of active zones and synaptic size, the graded nature of synaptic recruitment is likely one means of titrating synaptic efficacy for the graded depolarization on the non-spiking muscle fiber. Synapses in this preparation would appear to have a quantal signature that can be used for quantifying their activity which is useful in estimating the overall number of active sites. We use mixture modeling to estimate n (number of active sites) and p (probability of vesicle fusion) from the quantal characteristics. In a preparation that was stimulated at 40Hz, synapses were recruited (increase in n) and the number active synapses increased in p. In a different preparation, p increased as the stimulation was changed from 20 to 40Hz, but n did not show a substantial increase; however, during the STF train, p increases slightly. This study provides a novel approach in determining subsets of the single evoked quanta to better estimate n and p which describe synaptic function

Design and performance of the antenna coupled lumped-element kinetic inductance detector

Focal plane arrays consisting of low-noise, polarisation-sensitive detectors have made possible the pioneering advances in the study of the cosmic microwave background (CMB). To make further progress, the next generation of CMB experiments (e.g. CMB-S4) will require a substantial increase in the number of detectors compared to the current stage 3 instruments. Arrays of kinetic inductance detectors (KIDs) provide a possible path to realising such large format arrays owing to their intrinsic multiplexing advantage and relative cryogenic simplicity. In this proceedings, we report on the design of a novel variant of the traditional KID design; the antenna-coupled lumped-element KID. A polarisation sensitive twin-slot antenna placed behind an optimised hemispherical lens couples power onto a thin-film superconducting microstrip line. The power is then guided into the inductive section of an aluminium KID where it is absorbed and modifies both the resonant frequency and quality factor of the KID. We present the various aspects of the design and preliminary results from the first set of seven-element prototype arrays and compare to the expected modelled performance

Delocalization of wave packets in disordered nonlinear chains

We consider the spatiotemporal evolution of a wave packet in disordered nonlinear Schr\"odinger and anharmonic oscillator chains. In the absence of nonlinearity all eigenstates are spatially localized with an upper bound on the localization length (Anderson localization). Nonlinear terms in the equations of motion destroy Anderson localization due to nonintegrability and deterministic chaos. At least a finite part of an initially localized wave packet will subdiffusively spread without limits. We analyze the details of this spreading process. We compare the evolution of single site, single mode and general finite size excitations, and study the statistics of detrapping times. We investigate the properties of mode-mode resonances, which are responsible for the incoherent delocalization process.Comment: 14 pages, 9 figures, accepted for publication in Phys. Rev.

The redshift distribution of dusty star forming galaxies from the SPT survey

We use the Atacama Large Millimeter/submillimeter Array (ALMA) in Cycle 1 to determine spectroscopic redshifts of high-redshift dusty star-forming galaxies (DSFGs) selected by their 1.4mm continuum emission in the South Pole Telescope (SPT) survey. We present ALMA 3mm spectral scans between 84-114GHz for 15 galaxies and targeted ALMA 1mm observations for an additional eight sources. Our observations yield 30 new line detections from CO, [CI] , [NII] , H_2O and NH_3. We further present APEX [CII] and CO mid-J observations for seven sources for which only a single line was detected in spectral-scan data from ALMA Cycle 0 or Cycle 1. We combine the new observations with previously published and new mm/submm line and photometric data of the SPT-selected DSFGs to study their redshift distribution. The combined data yield 39 spectroscopic redshifts from molecular lines, a success rate of >85%. Our sample represents the largest data set of its kind today and has the highest spectroscopic completeness among all redshift surveys of high-z DSFGs. The median of the redshift distribution is z=3.9+/-0.4, and the highest-redshift source in our sample is at z=5.8. We discuss how the selection of our sources affects the redshift distribution, focusing on source brightness, selection wavelength, and strong gravitational lensing. We correct for the effect of gravitational lensing and find the redshift distribution for 1.4mm-selected sources with a median redshift of z=3.1+/-0.3. Comparing to redshift distributions selected at shorter wavelengths from the literature, we show that selection wavelength affects the shape of the redshift distribution

Nest-site competition between bumblebees (Bombidae), social wasps (Vespidae) and cavity-nesting birds in Britain and the Western Palearctic

Capsule: There is no evidence of widespread significant nest-site competition in Britain or the Western Palearctic between cavity-nesting birds and bumblebees or social wasps. Aims: To investigate competition between cavity-nesting birds and bumblebees and wasps, particularly the range-expanding Tree Bumblebee, Saxon Wasp and European Hornet in Britain, and review evidence throughout the Western Palearctic. Methods: We compared field data from English and Polish studies of tits and woodpeckers breeding in nest-boxes and/or tree holes to assess nest-site competition with bumblebees and wasps. We reviewed the literature quantifying nest-site competition between birds and these insects in the Western Palearctic. Results: Bumblebees and wasps are capable of usurping small passerines from nests. In England, these insects commandeered a mean annual 4.1% of tit nests initiated in nest-boxes; occurrence of hornets showed a long-term increase, but not other wasps or bumblebees. Across the Western Palearctic, insect occupation of nest-boxes was generally low, and was lower in England than in Poland. No insects were discovered in tree cavities, including those created by woodpeckers (Picidae). Conclusion: Nest-site competition between cavity-nesting birds and bumblebees and wasps appears to be a ‘nest-box phenomenon’, which may occasionally interfere with nest-box studies, but appears negligible in natural nest-sites