Tailoring the gradient ultrafine-grained structure in low-carbon steel during drawing with shear

Conventional drawing and drawing with shear were conducted on the rods of low-carbon steel. Deformation by simple drawing forms basically a homogenous structure and leads to a uniform change in microhardness along the billet volume. A comparative analysis of the models of these processes showed that shear drawing of steel at room temperature reduces energy characteristics in half, normal forces on the die – by 1,8, and enhances the strain intensity from 0,5 to 1,6. During drawing with shear, strain-induced cementite dissolution occurs and a gradient structure is formed, which increases the microhardness of the surface layer up to values close to 7 000 MPa

Tailoring the gradient ultrafine-grained structure in low-carbon steel during drawing with shear

Conventional drawing and drawing with shear were conducted on the rods of low-carbon steel. Deformation by simple drawing forms basically a homogenous structure and leads to a uniform change in microhardness along the billet volume. A comparative analysis of the models of these processes showed that shear drawing of steel at room temperature reduces energy characteristics in half, normal forces on the die – by 1,8, and enhances the strain intensity from 0,5 to 1,6. During drawing with shear, strain-induced cementite dissolution occurs and a gradient structure is formed, which increases the microhardness of the surface layer up to values close to 7 000 MPa

Inflammatory markers in cystic fibrosis patients with lung Pseudomonas aeruginosa infection.

Chronic endobronchial inflammation and bacterial infection are the main causes of morbidity and mortality in cystic fibrosis (CF), an autosomal recessive genetic disorder associated with improper function of chloride channels. Inflammation in CF lung is greatly amplified after Pseudomonas aeruginosa infection. In this study the relationship between P. aeruginosa status and inflammatory markers has been investigated. Seventeen CF children in acute lung exacerbation were examined. CF patients without P. aeruginosa infection were characterized by elevated activity of sputum elastase, reduced response of peripheral blood lymphocytes to PHA and significant resistance to the antiproliferative action of glucocorticoids. These parameters were normalized after antibiotic treatment. The patients with prolonged P. aeruginosa infection demonstrated extremely high levels of elastase activity and elevated amounts of sputum IL-8 and TNF-alpha. Although antibiotic treatment resulted in clinical improvement, it failed to suppress excessive immune response in the lung. The data indicate that CF patients with prolonged P. aeruginosa need the modified treatment, which should include immunomodulating drugs and protease inhibitors as well as antibacterial therapy

The program "client's voice" as a tool of business structure innovations

© by the author(s). The purpose of this article is aimed at improvement of interaction between a customer and a manufacturer on the basis of quality management methods development in the business structure. The article demonstrates the quality functions' structuring of the final product based on the study of explicit and implicit needs of the client at the products' design stage or its updating. The basis of the presented paper is the ideas of total quality Management, principles of products quality continuous improvement, production losses reduce and lean manufacturing. The article presents the concept of information support of the program "client's voice", which includes the necessary knowledge and information sources, method of information preservation and use, method of information formalizing from the client. This article is intended for business leaders, top Managers, researchers, all who are involved in the process of development and quality control in business organizations

Heterogeneity of population of microorganisms grown in presence of iron oxide maghemite nanoparticles

In this work γ-Fe2O3 MNPs were obtained by laser target evaporation and water based suspensions were prepared. Maximum permissive dose of iron in water (MPD) is 0.3 mg/L. It was found that 100 MPD dose of iron induces formation of non-typical colonies after 72 or 96 hours exposition: against a background of small black colonies large white colonies appeared due to a disruption in tyrosine synthesis. Multiple re-cloning of the white colonies grown with MNPs showed that they retained their properties both under standard conditions (temperature of 24 °C) and at the temperatures up to 37o C. E.nigrum grown with MNPs demonstrated very scant extension of small colonies at the cultivation temperature of 24o C, their growth was completely blocked at 37°C. Significant changes in the structure of the population were noted. First of all, large cells with pronounced aggregation were observed among the black colonies. These aggregates consisted of large cells connected to each other by matrix. In the white colonies the appearance of very long threadlike cells connecting different groups of the cells establishing an intercellular communication was evident. Fe2O3 MNPs induce an increase in the heterogeneity of the population, expressed as a change in morpho-physiological states. © 2018 The Authors, published by EDP Sciences.The work was supported by the Ministry of Education and Science of the Russian Federation (project No. 3.6121.210 )7 and R FFI №16-34-015 92 grant s. e tW hank R ndrA ade, Iu. Novoselova and I.V. Beketov for special support. Selected measurements were made at ISG KER services UPV/EHU

Diffuse-Charge Dynamics in Electrochemical Systems

The response of a model micro-electrochemical system to a time-dependent applied voltage is analyzed. The article begins with a fresh historical review including electrochemistry, colloidal science, and microfluidics. The model problem consists of a symmetric binary electrolyte between parallel-plate, blocking electrodes which suddenly apply a voltage. Compact Stern layers on the electrodes are also taken into account. The Nernst-Planck-Poisson equations are first linearized and solved by Laplace transforms for small voltages, and numerical solutions are obtained for large voltages. The ``weakly nonlinear'' limit of thin double layers is then analyzed by matched asymptotic expansions in the small parameter $\epsilon = \lambda_D/L$, where $\lambda_D$ is the screening length and $L$ the electrode separation. At leading order, the system initially behaves like an RC circuit with a response time of $\lambda_D L / D$ (not $\lambda_D^2/D$), where $D$ is the ionic diffusivity, but nonlinearity violates this common picture and introduce multiple time scales. The charging process slows down, and neutral-salt adsorption by the diffuse part of the double layer couples to bulk diffusion at the time scale, $L^2/D$. In the ``strongly nonlinear'' regime (controlled by a dimensionless parameter resembling the Dukhin number), this effect produces bulk concentration gradients, and, at very large voltages, transient space charge. The article concludes with an overview of more general situations involving surface conduction, multi-component electrolytes, and Faradaic processes.Comment: 10 figs, 26 pages (double-column), 141 reference

МОРФОЛОГІЧНІ І МІКРОБІОЛОГІЧНІ ОСОБЛИВОСТІ ЗАГОЄННЯ ПОКРИВНИХ ТКАНИН ПІСЛЯ МІСЦЕВОГО ПРОМЕНЕВОГО ПОШКОДЖЕННЯ

Узагальнені результати комплексного експериментально-морфологічного дослідження особливостей загоєння променевої виразки шкіри (ПВШ), інфікованої Pseudomonas aeruginosa (P. aeruginosa), у порівнянні з неінфікованою ПВШ. Інфікована ПВШ характеризувалася багатошаровою будовою, що залежало від тривалості експерименту. Процеси загоєння інфікованої ПВШ у порівнянні з неінфікованою значно уповільнені

Experience in managing patients with Churg-Strauss syndrome.

Our goal was to analyze the possibilities of impro­ving the diagnostics of CSS and to improve the effectiveness of treatment according to the existing literature and our own experience of long-term care for patients with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS). The medical histories of three female patients aged 26 to 46-years and a 20-year-old male patient were considered. The duration of the disease before the established diagnosis was 5-17 years. Anamnesis and medical documents analysis showed a typical CSS debut in the form of allergic rhinitis, nasal polyps, which were recurrent after polypectomy, and respiratory disorders, which were regarded as bronchitis or bronchial asthma – corresponding to the first phase, also called the prodromal or allergic stage of CSS. The prodromal period lasts up to 10 years or more and is characterized by various allergic manifestations, more often –  pollinosis or bronchial asthma, that is difficult to control. But CSS can be suspected because of low effectiveness of the therapy with inhaled steroids, lack of effect of antibiotics and eosinophilia more than 10% that occurs periodically. Even in the third stage of CSS in systemic manifestations of vasculitis and severe secondary lesions of organs and tissues with functional impairment, constant intake of maintenance doses of corticosteroids and cytostatics allows to achieve stabilization of the process in patients with CSS

Management of patients with hyperglycemia (diabetes mellitus). Management of patients with hypoglycemic states

methodical recommendationsThe methodological recommendations outline the issues of diagnosis and differential diagnosis of carbohydrate metabolism disorders, algorithms for the treatment of hyperglycemia, specific diabetes, and hypoglycemic states

Changes in morphotype in the population of E.coli in the presence of metal containing nanoparticles

The level of variability of the E.coli morphotype under the influence of iron oxide nanoparticles (MNPs) depending on their concentration was studied as well as the adaptive capabilities of the microbial population under growth conditions was evaluated.The presence of γ-Fe2O3 nanoparticles in the cultivation fluid affects the cultural and morphological properties of the microbial population of E.coli in the process of its development. The appearance of new morphotypes of colonies and cells can be considered as a manifestation of an adaptive mechanism. A change in the morphology of the microbial cell with a high concentration of MNPs leads to abnormal growth and disruption of the division process. © Published under licence by IOP Publishing Ltd.MAT2017-83631-C3In part this research was supported by the Spanish Government under project MAT2017-83631-C3. We thank I.V. Beketov and O.M. Samatov for special support