A novel method to determine dynamic temperature trends applied to in-shoe temperature data during walking

Body temperature is one of the fundamental measures considered in the assessment of health and wellbeing, with various medical conditions known to give rise to abnormal changes in temperature. In particular, abnormal variations in dynamic temperature patterns during walking or exercise may be linked to a range of foot problems, which are of particular concern in diabetic patients. A number of studies have investigated normative temperature patterns of a population by considering data from multiple participants and averaging results after an acclimatisation interval. In this work we demonstrate that the temperature patterns obtained using such an approach may not be truly representative of temperature changes in a population, and the averaging process adopted may yield skewed results. In this work we propose an alternative approach to determine generic reference temperature patterns based on a minimization of root mean square differences between time-shifted versions of temperature data collected from multiple participants. The results obtained indicate that this approach can yield a general trend that is more representative of actual temperature changes across a population than conventional averaging methods. The method we propose is also shown to better capture and link the effects of underlying factors that influence dynamic temperature trends, which could in turn lead to a better understanding of underlying physiological phenomena

A Comparison between Rotating Squares and Anti-Tetrachiral Systems: Influence of Ligaments on the Multi-Axial Mechanical Response

Rotating unit systems are one of the most important and well-known classes of auxetic mechanical metamaterials. As their name implies, when loaded, these systems deform primarily via rotation of blocks of material, which may be connected together either directly through joints (or ‘joint-like’ connections made by overlapping vertices of the rotating units) as in the case of rotating rigid polygonal-unit systems or by ligaments/ribs as in the case of chiral honeycombs. In this work, we used Finite Element Analysis to investigate the effect which the presence/absence of ligaments has on the on-axis and off-axis mechanical properties of these systems by analysing two of the most well-known structures which characterise these two cases: the rotating square system and the anti-tetrachiral honeycomb. It was found that while the presence of ligaments has a negligible effect on the on-axis Poisson’s ratio of these systems, it has a profound influence on nearly all other mechanical properties as well as on the off-axis loading behaviour. Systems with ligaments were found to exhibit a high level of anisotropy and also a severely reduced level of stiffness in comparison to their non-ligamented counterparts. On the other hand, the rotating square system suffers from high localized stress-intensities and has a very low strain-tolerance threshold. In addition, an optimized ‘hybrid’ geometry which is specifically designed to capture the best features of both the anti-tetrachiral and rotating square system, was also analysed. This work shows the main differences between ligament-based and non-ligament-based auxetic structures and also highlights the importance of considering the off-axis mechanical response in addition to the on-axis properties when investigating such systems

Development and prototyping of SMA-metamaterial biaxial composite actuators

Shape memory alloys (SMA) are excellent candidates for implementation in actuator systems due to their ability to recover their original shape after high-strain loading through a thermally-induced phase transition. In this work, we propose and develop a novel SMA-metamaterial actuator which is capable of exhibiting a reversible, global elongation in multiple directions induced by the unidirectional contraction upon heating of a single SMA component. This actuator consists of (a) an SMA component, (b) a bias component and (c) the metamaterial geometry, with each component having a distinct function: (a) actuation activation, (b) reversibility of actuation upon deactivation and (c) amplifying and re-directing the uni-directional SMA actuation globally throughout the actuator, respectively. A prototype actuator was designed and tested in various configurations over multiple activation/deactivation cycles in order to demonstrate the functionality and reusability of this system. Furthermore, a theoretical model which predicts the actuation stroke of the system on the basis of the material properties of the SMA and bias components as well as the geometry of the metamaterial system was developed and validated. The findings of this work demonstrate the considerable potential of SMA-metamaterial actuators for implementation in systems requiring a multi-axial actuation output

Physical Activity and Mindfulness are Associated with Lower Anxiety in Different but Complementary Ways

International Journal of Exercise Science 15(7): 1075-1084, 2022. Introduction: Anxiety is the most prevalent mental illness worldwide. Physical activity and mindfulness both reduce anxiety. The two are highly related; however, the relative association of physical activity and mindfulness on anxiety has yet to be examined. The present study aimed to evaluate the unique variance accounted for by physical activity and mindfulness on anxiety. Methods: Fifty young adults from a student population (M ± SD = 19 ± 0.2 years old; 58% female) reported their physical activity, mindfulness, and anxiety symptoms at the start of the study and reported their change in state anxiety to an acute psychological stress test, Trier Social Stress Test. Results: Mindfulness explained more of the variance associated with anxiety symptoms at baseline, whereas physical activity explained more of the variance associated with change in state anxiety in response to the acute stressor. Females had higher rates of anxiety symptoms than males suggesting that females may benefit more from mindfulness. In contrast, both males and females reacted similarly to an acute stressor suggesting that both genders may benefit from physical activity. Conclusions: Our findings suggest that physical activity and trait mindfulness may have related, but distinct impacts on anxiety levels. These results have important implications for using these lifestyle interventions to support mental health and point to personalizing interventions to help ease the burden of anxiety felt by the individual

Assimilating compact phase space retrievals (CPSRs): comparison with independent observations (MOZAIC in situ and IASI retrievals) and extension to assimilation of truncated retrieval profiles

Assimilation of atmospheric composition retrievals presents computational challenges due to their high data volume and often sparse information density. Assimilation of compact phase space retrievals (CPSRs) meets those challenges and offers a promising alternative to assimilation of raw retrievals at reduced computational cost (Mizzi et al., 2016). This paper compares analysis and forecast results from assimilation of Terra/Measurement of Pollution in the Troposphere (MOPITT) carbon monoxide (CO) CPSRs with independent observations. We use MetOp-A/Infrared Atmospheric Sounding Interferometer (IASI) CO retrievals and Measurement of OZone, water vapor, carbon monoxide, and nitrogen oxides by in-service AIrbus airCraft (MOZAIC) in situ CO profiles for our independent observation comparisons. Generally, the results confirm that assimilation of MOPITT CPSRs improves the Weather Research and Forecasting model with chemistry coupled to the ensemble Kalman filter data assimilation from the Data Assimilation Research Testbed (WRF-Chem/DART) analysis fit and forecast skill at a reduced computational cost compared to assimilation of raw retrievals. Comparison with the independent observations shows that assimilation of MOPITT CO generally improved the analysis fit and forecast skill in the lower troposphere but degraded it in the upper troposphere. We attribute that degradation to assimilation of MOPITT CO retrievals with a possible bias of  ∼ 14&thinsp;% above 300&thinsp;hPa. To discard the biased retrievals, in this paper, we also extend CPSRs to assimilation of truncated retrieval profiles (as opposed to assimilation of full retrieval profiles). Those results show that not assimilating the biased retrievals (i) resolves the upper tropospheric analysis fit degradation issue and (ii) reduces the impact of assimilating the remaining unbiased retrievals because the total information content and vertical sensitivities are changed.</p

A 12-week exercise programme has a positive effect on everyday executive function in young people with Down syndrome: a pilot non-randomised controlled trial

Background: Exercise has the potential to reduce cognitive decline in people with Down syndrome by maximising their cognitive function. The aim of the study was to determine the effect of regular exercise on cognitive functioning in young people with Down syndrome. Method: People with Down syndrome were eligible if aged between 13 and 35 years and enrolled to participate in an exercise programme (called FitSkills). The intervention was a 12-week community-based exercise programme completed with a student mentor. Outcomes were assessed before (week 0) and immediately after (week 13) the intervention. Executive functioning (planning, response inhibition, attention shifting) was assessed using Tower of London, Sustained Attention to Response Task, CANTAB Intra-extra Dimensional Set Shift Test, Cognitive Scale for Down Syndrome, and Behaviour Rating Inventory of Executive Function (BRIEF). Working memory was assessed using the CANTAB Paired Associates Learning task, and information processing speed was assessed using the Motor Screening Task. Outcomes were analysed using ANCOVA with the baseline measure as the covariate. Results: Twenty participants (9 women; mean age 23.6 ± 6.6 years) enrolled. Between-group differences, in favour of the experimental group, were found for the global executive composite score of the BRIEF (mean difference −4.77 units, 95% CI −9.30 to −0.25). There were no between group differences for any other outcome measured. Conclusion: Participation in a 12-week exercise programme was effective in improving everyday executive functions in young people with Down syndrome. These preliminary findings need to be confirmed in future randomised controlled trials of community-based exercise with larger sample sizes

Stigma narratives: LGBT transitions and identities in Malta

This article is available open access through the publisher’s website at the link below. Copyright @ 2011 A B Academic Publishers.This article considers narratives of transition experiences of a group of Lesbian, Gay, Bisexual and Transgender (LGBT) young people in Malta. The article draws on Goffman's concept of stigma and uses this to explore transitions in a society that retains some traditional characteristics, particularly the code of honour and shame, although mediated by aspects of modernity. Interviews were undertaken with 15 young people with the goal of producing narratives. The article analyses the experience of stigma, its effects and how young people manage its consequences. It concludes by drawing attention to the pervasive nature of stigma and the importance of structure, agency and reflexivity in youth transitions. In particular stigma remains an important feature of societies in which hetero-normative sexuality remains dominant

CryoSat Ice Baseline-D validation and evolutions

The ESA Earth Explorer CryoSat-2 was launched on 8 April 2010 to monitor the precise changes in the thickness of terrestrial ice sheets and marine floating ice. To do that, CryoSat orbits the planet at an altitude of around 720 km with a retrograde orbit inclination of 92∘ and a quasi repeat cycle of 369 d (30 d subcycle). To reach the mission goals, the CryoSat products have to meet the highest quality standards to date, achieved through continual improvements of the operational processing chains. The new CryoSat Ice Baseline-D, in operation since 27 May 2019, represents a major processor upgrade with respect to the previous Ice Baseline-C. Over land ice the new Baseline-D provides better results with respect to the previous baseline when comparing the data to a reference elevation model over the Austfonna ice cap region, improving the ascending and descending crossover statistics from 1.9 to 0.1 m. The improved processing of the star tracker measurements implemented in Baseline-D has led to a reduction in the standard deviation of the point-to-point comparison with the previous star tracker processing method implemented in Baseline-C from 3.8 to 3.7 m. Over sea ice, Baseline-D improves the quality of the retrieved heights inside and at the boundaries of the synthetic aperture radar interferometric (SARIn or SIN) acquisition mask, removing the negative freeboard pattern which is beneficial not only for freeboard retrieval but also for any application that exploits the phase information from SARIn Level 1B (L1B) products. In addition, scatter comparisons with the Beaufort Gyre Exploration Project (BGEP; https://www.whoi.edu/beaufortgyre, last access: October 2019) and Operation IceBridge (OIB; Kurtz et al., 2013) in situ measurements confirm the improvements in the Baseline-D freeboard product quality. Relative to OIB, the Baseline-D freeboard mean bias is reduced by about 8 cm, which roughly corresponds to a 60 % decrease with respect to Baseline-C. The BGEP data indicate a similar tendency with a mean draft bias lowered from 0.85 to −0.14 m. For the two in situ datasets, the root mean square deviation (RMSD) is also well reduced from 14 to 11 cm for OIB and by a factor of 2 for the BGEP. Observations over inland waters show a slight increase in the percentage of good observations in Baseline-D, generally around 5 %–10 % for most lakes. This paper provides an overview of the new Level 1 and Level 2 (L2) CryoSat Ice Baseline-D evolutions and related data quality assessment, based on results obtained from analyzing the 6-month Baseline-D test dataset released to CryoSat expert users prior to the final transfer to operations

Capturing the personal through the lens of the professional: The use of external data sources in autoethnography

This article shows how external data sources can be utilised in autoethnographic research. Beginning with an account of a critical incident that examines the incompatibility of private and professional identities, I show how, through the collection of data sources, I capture the impact of homophobic and heteronormative discursive practices on health, wellbeing and identity. In the critical incident, I explore how I prospered as a teacher at a British village school for almost 10 years by censoring my sexuality and carefully managing the intersection between my private and professional identities. However, when a malicious and homophobic neighbour and parent of children at the school exposed my sexuality to the Headteacher, I learned the extent to which the rural school community privileged and protected the heteronormative discourse. A poststructuralist theoretical framework underpins this article. My experience of being a subject is understood as the outcome of discursive practices. Sexual identity, teacher identity and autoethnographer identity are understood to be fluid, and constantly produced and reproduced in response to social, cultural and political influences. The article describes how email correspondence, medical records and notes from a course of cognitive behaviour therapy were deployed to augment my personal recollection and give a depth and richness to the narrative. As the critical incident became a police matter, examination takes place of how I sought to obtain and utilise data from the police national computer in the research. Attempts to collect data from the police and Crown Prosecution Service were problematic and provided an unexpected development in the research and offered additional insight into the nature of the British rural community and its police force

Pseudoexon activation increases phenotype severity in a Becker muscular dystrophy patient

We report a dystrophinopathy patient with an in-frame deletion of DMD exons 45–47, and therefore a genetic diagnosis of Becker muscular dystrophy, who presented with a more severe than expected phenotype. Analysis of the patient DMD mRNA revealed an 82 bp pseudoexon, derived from intron 44, that disrupts the reading frame and is expected to yield a nonfunctional dystrophin. Since the sequence of the pseudoexon and canonical splice sites does not differ from the reference sequence, we concluded that the genomic rearrangement promoted recognition of the pseudoexon, causing a severe dystrophic phenotype. We characterized the deletion breakpoints and identified motifs that might influence selection of the pseudoexon. We concluded that the donor splice site was strengthened by juxtaposition of intron 47, and loss of intron 44 silencer elements, normally located downstream of the pseudoexon donor splice site, further enhanced pseudoexon selection and inclusion in the DMD transcript in this patient