2,432 research outputs found

    Mass as Quantity of Matter

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    'Effective Forces.'

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    Patients' experiences of brief cognitive behavioral therapy for eating disorders: A qualitative investigation

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    Objective Although it is important to analyze the effectiveness of new therapies, it is also necessary to consider how patients experience them. This is particularly important if we are to maximize treatment acceptability and reduce attrition. This study examined patient experiences of a new 10‐session cognitive‐behavioral therapy (CBT‐T), using a qualitative approach. Method The sample was 17 patients with a diagnosis of bulimia nervosa who had received CBT‐T (including treatment completers and non‐completers) within the previous 2 years. Sample size was determined by saturation of the emergent themes. Responses were analyzed using a six‐step thematic analysis process. Results Rated acceptability and effectiveness of CBT‐T were high. Five themes emerged, with subthemes. The key elements of patient experience of the therapy were: the therapeutic relationship; the nature of the therapy; its challenging but beneficial aspects; ending therapy; and the overall experience of CBT‐T (including comparison with other therapies). Discussion The findings build on the effectiveness research for CBT‐T, suggesting that it is an acceptable therapy that addresses many of the same themes that matter to patients as other therapies. The findings show that patients were positive about CBT‐T relative to other therapies, and offer suggestions as to how CBT‐T might be delivered to emphasize the importance of the time‐limited nature of the therapy

    A Search for Scalar Chameleons with ADMX

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    Scalar fields with a "chameleon" property, in which the effective particle mass is a function of its local environment, are common to many theories beyond the standard model and could be responsible for dark energy. If these fields couple weakly to the photon, they could be detectable through the "afterglow" effect of photon-chameleon-photon transitions. The ADMX experiment was used in the first chameleon search with a microwave cavity to set a new limit on scalar chameleon-photon coupling excluding values between 2*10^9 and 5*10^14 for effective chameleon masses between 1.9510 and 1.9525 micro-eV.Comment: 4 pages, 3 figure

    A SQUID-based microwave cavity search for dark-matter axions

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    Axions in the micro eV mass range are a plausible cold dark matter candidate and may be detected by their conversion into microwave photons in a resonant cavity immersed in a static magnetic field. The first result from such an axion search using a superconducting first-stage amplifier (SQUID) is reported. The SQUID amplifier, replacing a conventional GaAs field-effect transistor amplifier, successfully reached axion-photon coupling sensitivity in the band set by present axion models and sets the stage for a definitive axion search utilizing near quantum-limited SQUID amplifiers.Comment: 4 pages, 5 figures, submitted to PR

    Copy number variants in pharmacogenetic genes

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    Variation in drug efficacy and toxicity remains an important clinical concern. Presently, single nucleotide polymorphisms (SNP) only explain a portion of this problem, even in situations where the pharmacological trait is clearly heritable. The Human CNV Project identified copy number variations (CNVs) across approximately 12% of the human genome, and these CNVs were considered causes of diseases. Although the contribution of CNVs to the pathogenesis of many common diseases is questionable, CNVs play a clear role in drug related genes by altering drug metabolizing and drug response. Here we provide a comprehensive review of the clinical relevance of CNVs to drug efficacy, toxicity, disease prevalence in world populations and discuss the implication of using CNVs as diagnosis in clinical intervention

    Stratifying quotient stacks and moduli stacks

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    Recent results in geometric invariant theory (GIT) for non-reductive linear algebraic group actions allow us to stratify quotient stacks of the form [X/H], where X is a projective scheme and H is a linear algebraic group with internally graded unipotent radical acting linearly on X, in such a way that each stratum [S/H] has a geometric quotient S/H. This leads to stratifications of moduli stacks (for example, sheaves over a projective scheme) such that each stratum has a coarse moduli space.Comment: 25 pages, submitted to the Proceedings of the Abel Symposium 201

    Constraints for hypothetical interactions from a recent demonstration of the Casimir force and some possible improvements

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    The Casimir force is calculated in the configuration of a spherical lens and a disc of finite radius covered by CuCu and AuAu thin layers which was used in a recent experiment. The correction to the Casimir force due to finiteness of the disc radius is shown to be negligible. Also the corrections are discussed due to the finite conductivity, large-scale and short-scale deviations from the perfect shape of the bounding surfaces and the temperature correction. They were found to be essential when confronting the theoretical results with experimental data. Both Yukawa-type and power-law hypothetical forces are computed which may act in the configuration under consideration due to the exchange of light and/or massless elementary particles between the atoms of the lens and the disc. New constraints on the constants of these forces are determined which follow from the fact that they were not observed within the limits of experimental errors. For Yukawa-type forces the new constraints are up to 30 times stronger than the best ones known up today. A possible improvement of experimental parameters is proposed which gives the possibility to strengthen constraints on Yukawa-type interactions up to 10410^4 times and on power-law interactions up to several hundred times.Comment: 15 pages, 3 figures, subm. to Phys. Rev.

    Local Gravity Constraints and Power Law f(R) Theories

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    There is a conformal equivalence between power law f(R)f(R) theories and scalar field theories in which the scalar degree of freedom evolves under the action of an exponential potential function. In the scalar field representation there is a strong coupling of the scalar field with the matter sector due to the conformal transformation. We use chameleon mechanism to implement constraints on the potential function of the scalar field in order that the resulting model be in accord with Solar System experiments. Investigation of these constraints reveals that there may be no possibility to distinguish between a power law f(R)f(R) function and the usual Einstein-Hilbert Lagrangian density.Comment: 11 Pages, no figure. To appear in Gravitation and Cosmolog

    Nonlinear acousto-electric transport in a two-dimensional electron system

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    We study both theoretically and experimentally the nonlinear interaction between an intense surface acoustic wave and a two-dimensional electron plasma in semiconductor-piezocrystal hybrid structures. The experiments on hybrid systems exhibit strongly nonlinear acousto-electric effects. The plasma turns into moving electron stripes, the acousto-electric current reaches its maximum, and the sound absorption strongly decreases. To describe the nonlinear phenomena, we develop a coupled-amplitude method for a two-dimensional system in the strongly nonlinear regime of interaction. At low electron densities the absorption coefficient decreases with increasing sound intensity, whereas at high electron density the absorption coefficient is not a monotonous function of the sound intensity. High-harmonic generation coefficients as a function of the sound intensity have a nontrivial behavior. Theory and experiment are found to be in a good agreement.Comment: 27 pages, 6 figure
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