2,432 research outputs found
Patients' experiences of brief cognitive behavioral therapy for eating disorders: A qualitative investigation
Objective
Although it is important to analyze the effectiveness of new therapies, it is also necessary to consider how patients experience them. This is particularly important if we are to maximize treatment acceptability and reduce attrition. This study examined patient experiences of a new 10âsession cognitiveâbehavioral therapy (CBTâT), using a qualitative approach.
Method
The sample was 17 patients with a diagnosis of bulimia nervosa who had received CBTâT (including treatment completers and nonâcompleters) within the previous 2 years. Sample size was determined by saturation of the emergent themes. Responses were analyzed using a sixâstep thematic analysis process.
Results
Rated acceptability and effectiveness of CBTâT were high. Five themes emerged, with subthemes. The key elements of patient experience of the therapy were: the therapeutic relationship; the nature of the therapy; its challenging but beneficial aspects; ending therapy; and the overall experience of CBTâT (including comparison with other therapies).
Discussion
The findings build on the effectiveness research for CBTâT, suggesting that it is an acceptable therapy that addresses many of the same themes that matter to patients as other therapies. The findings show that patients were positive about CBTâT relative to other therapies, and offer suggestions as to how CBTâT might be delivered to emphasize the importance of the timeâlimited nature of the therapy
A Search for Scalar Chameleons with ADMX
Scalar fields with a "chameleon" property, in which the effective particle
mass is a function of its local environment, are common to many theories beyond
the standard model and could be responsible for dark energy. If these fields
couple weakly to the photon, they could be detectable through the "afterglow"
effect of photon-chameleon-photon transitions. The ADMX experiment was used in
the first chameleon search with a microwave cavity to set a new limit on scalar
chameleon-photon coupling excluding values between 2*10^9 and 5*10^14 for
effective chameleon masses between 1.9510 and 1.9525 micro-eV.Comment: 4 pages, 3 figure
A SQUID-based microwave cavity search for dark-matter axions
Axions in the micro eV mass range are a plausible cold dark matter candidate
and may be detected by their conversion into microwave photons in a resonant
cavity immersed in a static magnetic field. The first result from such an axion
search using a superconducting first-stage amplifier (SQUID) is reported. The
SQUID amplifier, replacing a conventional GaAs field-effect transistor
amplifier, successfully reached axion-photon coupling sensitivity in the band
set by present axion models and sets the stage for a definitive axion search
utilizing near quantum-limited SQUID amplifiers.Comment: 4 pages, 5 figures, submitted to PR
Copy number variants in pharmacogenetic genes
Variation in drug efficacy and toxicity remains an important clinical concern. Presently, single nucleotide polymorphisms (SNP) only explain a portion of this problem, even in situations where the pharmacological trait is clearly heritable. The Human CNV Project identified copy number variations (CNVs) across approximately 12% of the human genome, and these CNVs were considered causes of diseases. Although the contribution of CNVs to the pathogenesis of many common diseases is questionable, CNVs play a clear role in drug related genes by altering drug metabolizing and drug response. Here we provide a comprehensive review of the clinical relevance of CNVs to drug efficacy, toxicity, disease prevalence in world populations and discuss the implication of using CNVs as diagnosis in clinical intervention
Stratifying quotient stacks and moduli stacks
Recent results in geometric invariant theory (GIT) for non-reductive linear
algebraic group actions allow us to stratify quotient stacks of the form [X/H],
where X is a projective scheme and H is a linear algebraic group with
internally graded unipotent radical acting linearly on X, in such a way that
each stratum [S/H] has a geometric quotient S/H. This leads to stratifications
of moduli stacks (for example, sheaves over a projective scheme) such that each
stratum has a coarse moduli space.Comment: 25 pages, submitted to the Proceedings of the Abel Symposium 201
Constraints for hypothetical interactions from a recent demonstration of the Casimir force and some possible improvements
The Casimir force is calculated in the configuration of a spherical lens and
a disc of finite radius covered by and thin layers which was used in
a recent experiment. The correction to the Casimir force due to finiteness of
the disc radius is shown to be negligible. Also the corrections are discussed
due to the finite conductivity, large-scale and short-scale deviations from the
perfect shape of the bounding surfaces and the temperature correction. They
were found to be essential when confronting the theoretical results with
experimental data. Both Yukawa-type and power-law hypothetical forces are
computed which may act in the configuration under consideration due to the
exchange of light and/or massless elementary particles between the atoms of the
lens and the disc. New constraints on the constants of these forces are
determined which follow from the fact that they were not observed within the
limits of experimental errors. For Yukawa-type forces the new constraints are
up to 30 times stronger than the best ones known up today. A possible
improvement of experimental parameters is proposed which gives the possibility
to strengthen constraints on Yukawa-type interactions up to times and on
power-law interactions up to several hundred times.Comment: 15 pages, 3 figures, subm. to Phys. Rev.
Local Gravity Constraints and Power Law f(R) Theories
There is a conformal equivalence between power law theories and scalar
field theories in which the scalar degree of freedom evolves under the action
of an exponential potential function. In the scalar field representation there
is a strong coupling of the scalar field with the matter sector due to the
conformal transformation. We use chameleon mechanism to implement constraints
on the potential function of the scalar field in order that the resulting model
be in accord with Solar System experiments. Investigation of these constraints
reveals that there may be no possibility to distinguish between a power law
function and the usual Einstein-Hilbert Lagrangian density.Comment: 11 Pages, no figure. To appear in Gravitation and Cosmolog
Nonlinear acousto-electric transport in a two-dimensional electron system
We study both theoretically and experimentally the nonlinear interaction
between an intense surface acoustic wave and a two-dimensional electron plasma
in semiconductor-piezocrystal hybrid structures. The experiments on hybrid
systems exhibit strongly nonlinear acousto-electric effects. The plasma turns
into moving electron stripes, the acousto-electric current reaches its maximum,
and the sound absorption strongly decreases. To describe the nonlinear
phenomena, we develop a coupled-amplitude method for a two-dimensional system
in the strongly nonlinear regime of interaction. At low electron densities the
absorption coefficient decreases with increasing sound intensity, whereas at
high electron density the absorption coefficient is not a monotonous function
of the sound intensity. High-harmonic generation coefficients as a function of
the sound intensity have a nontrivial behavior. Theory and experiment are found
to be in a good agreement.Comment: 27 pages, 6 figure
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